Acute Effects of HIIT vs. MICT on HRV (MW2acute)

May 25, 2024 updated by: Borut Jug, University Medical Centre Ljubljana

Acute Effects of High Intensity Interval Training (HIIT) vs. Moderate Intensity Continuous Training (MICT) on Heart Rate Variability Parameters in Patients After Myocardial Infarction

Heart rate variability (HRV) is impaired in patients after myocardial infarction. Most studies so far have proved chronic beneficial effects of different types of exercise on HRV parameters. Data on acute effects of different types of exercise training (e.g. high intensity interval training [HIIT] and moderate intensity continuous training [MICT]) is scarce.

Patients in the study will perform both HIIT and MICT in a random order and in-between break of at least 48 hours. A 5-minute high resolution ECG recording will be performed before and immediately after both HIIT and MICT.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Slovenia
      • Ljubljana, Slovenia, 1000
        • Recruiting
        • University Medical Centre Ljubljana
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • myocardial infarction in last 120 days
  • sinus rhythm

Exclusion Criteria:

  • contraindications for exercise training
  • uncontrolled dysrhythmias
  • Heart Failure NYHA IV stage
  • cognitive impairment
  • pregnancy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: High intensity interval training (HIIT)
The high-intensity interval training session consists of 5-min warm-up and 5-min cool-down periods. The main part has 7 cycles. Each cycle consists of 1.5 min of 80-90% of HRpeak and 3 min of 65-70% of HRpeak.
Other: Type of Exercise
The high-intensity interval training session consists of 5-min warm-up and 5-min cool-down periods. The main part has 7 cycles. Each cycle consists of 1.5 min of 80-90% of HRpeak and 3 min of 65-70% of HRpeak. The moderate-intensity continuous training session consists of 5 min warm-up and 3-min cool down period. The main part consists of 32 min of 75% of HRpeak.
Active Comparator: Moderate intensity continuous training (MICT)
The moderate-intensity continuous training session consists of 5 min warm-up and 3-min cool down period. The main part consists of 32 min of 75% of HRpeak.
Other: Type of Exercise
The high-intensity interval training session consists of 5-min warm-up and 5-min cool-down periods. The main part has 7 cycles. Each cycle consists of 1.5 min of 80-90% of HRpeak and 3 min of 65-70% of HRpeak. The moderate-intensity continuous training session consists of 5 min warm-up and 3-min cool down period. The main part consists of 32 min of 75% of HRpeak.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
HF parameter
Time Frame: 5-minutes high resolution ECG recording before and after an exercise session
High frequency domain of the HRV
5-minutes high resolution ECG recording before and after an exercise session

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
LF parameter
Time Frame: 5-minutes high resolution ECG recording before and after an exercise session
Low frequency domain of the HRV
5-minutes high resolution ECG recording before and after an exercise session
SDNN
Time Frame: 5-minutes high resolution ECG recording before and after an exercise session
Standard deviation of NN intervals
5-minutes high resolution ECG recording before and after an exercise session
RMSSD
Time Frame: 5-minutes high resolution ECG recording before and after an exercise session
Root mean square of successive RR interval differences
5-minutes high resolution ECG recording before and after an exercise session
pNN50
Time Frame: 5-minutes high resolution ECG recording before and after an exercise session
Percentage of successive RR intervals that differ by more than 50 ms
5-minutes high resolution ECG recording before and after an exercise session

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Non-linear methods
Time Frame: 5-minutes high resolution ECG recording before and after an exercise session
SD1, SD2
5-minutes high resolution ECG recording before and after an exercise session

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Medical Centre Ljubljana

Investigators

  • Study Chair: Marko Novaković, MD, PhD, University Medical Centre Ljubljana

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 15, 2024

Primary Completion (Estimated)

June 1, 2024

Study Completion (Estimated)

June 15, 2024

Study Registration Dates

First Submitted

April 16, 2024

First Submitted That Met QC Criteria

May 25, 2024

First Posted (Actual)

May 31, 2024

Study Record Updates

Last Update Posted (Actual)

May 31, 2024

Last Update Submitted That Met QC Criteria

May 25, 2024

Last Verified

May 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • UKCLRehab2024/1

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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