Er:YAG Laser and Air Polishing Application in Periodontal Treatment

February 5, 2025 updated by: Beijing Chao Yang Hospital

Combined Application of Er:YAG Laser and Sub-gingival Air Polishing Powder in Treatment of Periodontitis: A Split-mouth, Randomized Controlled Trial

Periodontitis (gum disease) is an infection of the gums that can lead to tooth loss. In recent years, many types of dental lasers or other devices have been used for the non-surgical treatment of periodontal diseases. However, it remains unclear whether the combined application of laser and air polishing is effective as an adjuvant treatment for periodontitis. The purpose of this study is to compare the use of combined application of Er:YAG laser and sub-gingival air polishing powder, with the treatment of Er:YAG laser only, in periodontal diseases treatment in a Chinese population.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

The study will use a split-mouth design, two quadrants (one quadrant from each jaw) were randomly allocated to either the test or control group. The quadrants in the test group received Er:YAG laser (ERL) plus sub-gingival air polishing treatment, while the quadrants in the control group received ERL only. Clinical periodontal examinations were evaluated at baseline, 3 months, 6 months, 1 year, and 2 years.

Study Type

Interventional

Enrollment (Estimated)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • China
    • Beijing
      • Beijing, Beijing, China, 100020
        • Recruiting
        • Beijing Chao Yang Hospital
        • Contact:
          • Xuan Zhou, Dr.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • 1) aged 35-65 years old, in good systemic healthy;
  • 2) clinically diagnosed with generalized stage Ⅱ or stage Ⅲ periodontitis;
  • 3) a minimum of 20 teeth

Exclusion Criteria:

  • 1) pregnancy or recent pregnancy plans;
  • 2) had received periodontal treatment within the previous 6 months;
  • 3) taken antibiotics within the previous 3 months;
  • 4) had diabetes;
  • 5) obvious malocclusion, history of orthodontic treatment, or a habit of mouth breathing.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: test group
Er:YAG laser (ERL) plus sub-gingival air polishing treatment
Procedure: ERL + air polishing
Er:YAG laser (ERL) plus sub-gingival air polishing treatment
Placebo Comparator: control group
ERL treatment only
Procedure: ERL
ERL treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Changes in PD
Time Frame: at 3 months, 6 months, 1 year, and 2 years
Changes in probing depth (PD) measured using periodontal probing
at 3 months, 6 months, 1 year, and 2 years
Changes in CAL
Time Frame: at 3 months, 6 months, 1 year, and 2 years
Changes in clinical attachment level (CAL) measured using periodontal probing
at 3 months, 6 months, 1 year, and 2 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
changes in BI
Time Frame: at 3 months, 6 months, 1 year, and 2 years
Changes in bleeding index (BI) measured using periodontal probing
at 3 months, 6 months, 1 year, and 2 years
PLI
Time Frame: at 3 months, 6 months, 1 year, and 2 years
Plaque index (PLI) assessed by an examiner using a scale of 0 to 3
at 3 months, 6 months, 1 year, and 2 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Beijing Chao Yang Hospital

Investigators

  • Principal Investigator: GuangXu Liu, Doctor, Research Department

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 4, 2024

Primary Completion (Estimated)

December 1, 2026

Study Completion (Estimated)

December 1, 2027

Study Registration Dates

First Submitted

August 26, 2024

First Submitted That Met QC Criteria

August 26, 2024

First Posted (Actual)

August 28, 2024

Study Record Updates

Last Update Posted (Actual)

March 25, 2025

Last Update Submitted That Met QC Criteria

February 5, 2025

Last Verified

August 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CYFH202207

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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