Clinical Study of CD38\CS1 Chimeric Antigen Receptor T Cells in the Treatment of Refractory/Recurrent Multiple Myeloma

Professor of Medicine Second Hospital of Shandong University

The investigators developed a dual-target CAR-T targeting CD38 and CS1. Previous experimental results showed that the investigators double-target CAR-T not only had a good killing effect on CD38/CS1 double-positive tumor cells, but also had a high killing rate on CD38 or CS1 single-positive tumor cells. The investigators further study also found that the killing rate of the investigators dual-target CAR-T after mixing CD38 and CS1 monoyang tumor cells was over 80%. The advantage of the investigators dual-target CAR-T product is that the killing effect on single-yang, double-yang and single-yang mixed tumors is stable, and the killing rate is above 80% (see Figure 1). It has a wide killing range and can effectively reduce the phenomenon of tumor immune escape. Therefore, the investigators dual CAR products have good advantages and development potential.

Study Overview

• Status: Active, not recruiting
• Conditions: ORR,OS,PFS
• Intervention / Treatment: Biological: CD38/CS1 injection

• Study Type: Interventional
• Enrollment (Estimated): 10
• Phase: Early Phase 1

Contacts and Locations

Study Locations

• China
  • Shandong
    • Shandong, Shandong, China, 250000
      • Second hospital of Shandong university

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:1. Relapsed, refractory, drug-resistant MM. 2. MM patients who have not achieved CR in 4 cycles of standard treatment. 3. Age over 15 and under 75. 4. KPS≥50 or ECOG score ≤2 points and expected survival greater than 3 months. 5. No systemic therapy (except systemic immune checkpoint suppression or activation therapy) for at least 2 weeks or at least 5 drug half-lives (whichever is shorter) prior to apheresis. 6. The absolute number of neutrophils was > 1.0x109 /L. 7. Absolute number of platelets > 50x109 /L. 8. Absolute number of lymphocytes ≥ 0.15x109 /L. 9. ALT/AST < 3 times the normal value. 10. Total bilirubin < 1.5mg/dl. 11. Creatinine < 2.5mg/dl, or creatinine clearance ≥60 mL/min/1.73 m2. 12. Cardiac ejection fraction ≥ 45%, echocardiography (ECHO) showed no pericardial effusion, electrocardiogram (ECG) was normal 13. Blood oxygen saturation ≥92% under normal conditions. 14. Women of childbearing age who had a negative urine pregnancy test before the start of dosing and consented to effective contraceptive use during the trial period until the last follow-up visit. 15. Volunteer to participate in this experiment and sign the informed consent.

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Exclusion Criteria:1. Patients with expected survival of less than 3 months. 2. Patients whose disease progression was so rapid that a complete treatment cycle could not be ensured according to the investigator at the time of enrollment. 3. Patients with primary tumors other than melanoma skin cancer (e.g. cervical cancer, bladder cancer, breast cancer) (unless cured for more than 3 years). 4. Patients with infections including fungal, bacterial, viral or other uncontrolled infections or those requiring level 4 isolation. 5. Patients who test positive for HIV, HBV and HCV. 6. Patients with central nervous system diseases including stroke, epilepsy, dementia or autoimmune central nervous system diseases. 7. Patients with myocardial infection, cardiac angiography or stent, active angina pectoris or other significant clinical symptoms, or with cardiogenic asthma or cardiovascular plasma cell infiltration in the 12 months prior to enrollment. 8. People who are receiving anticoagulant therapy or have severe coagulation disorders. 9. According to the judgment of the researcher, the drug treatment that the patient is receiving will affect the safety and effectiveness study of this project. 10. Patients with allergy or history of allergy to the biologics used in this project. 11. Pregnant or lactating women. 12. Systematic use of systemic or systemic steroid drugs within 2 weeks prior to treatment (except those who have recently or currently used inhaled steroids). 13. The efficiency of T cell transduction by replication-deficient lentivirus is less than 30%, or the amplification ability is insufficient (times) in response to CD3 / CD28 co-stimulatory signals. 14. Patients with other uncontrolled diseases deemed unsuitable by the researchers. 15. Any situation that the investigator believes may increase the risk to the subject or interfere with the test results. 16. Patients who are also participating in other clinical studies.

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Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

Experimental: refractory or relapsed MM

Biological: CD38/CS1 injection; Dosage form and specification: injection, 40mL/ dose, according to the number of positive cells 1×106/kg Properties: Colorless or slightly light white clear liquid Prescription composition: CD38/CS1 CAR T cells, 2.5% human blood albumin, 0.9% sodium chloride injection. Administration mode: intravenous injection Storage condition: 2-8℃ for 8h Mechanism of action :38WP as a dual-target CAR T cell therapy, compared with single-target CAR T cell therapy, its advantage is that it can reduce antigen escape of tumor cells.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
ORR	sCR、CR、VGPR、PR	one year

Collaborators and Investigators

• Sponsor: The Second Hospital of Shandong University

Study record dates

Study Major Dates

• Study Start (Actual): April 30, 2024
• Primary Completion (Estimated): January 15, 2025
• Study Completion (Estimated): January 15, 2025

Study Registration Dates

• First Submitted: August 13, 2024
• First Submitted That Met QC Criteria: August 26, 2024
• First Posted (Actual): August 28, 2024

Study Record Updates

• Last Update Posted (Actual): August 28, 2024
• Last Update Submitted That Met QC Criteria: August 26, 2024
• Last Verified: August 1, 2024

More Information

Terms related to this study

• Other Study ID Numbers: 2024 CD38/CS1 T cell of MM

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No