Determinants of Bone Dimensional Changes After Extraction and Alveolar Ridge Preservation

The main purpose of the study is to measure and localize immediate post extraction changes i.e. socket expansion versus no width change along the socket wall and identify whether the immediate post-extraction ridge width condition (expansion or no change) is a determinant of buccolingual ridge width and height changes 4 months following extraction and ridge preservation.

Study Overview

• Status: Recruiting
• Conditions: Wound Healing; Alveolar Bone Grafting; Tooth Extraction Site Healing; Bone Healing
• Intervention / Treatment: Other: observational study

Detailed Description

The null hypothesis for this study is that there is no difference in bone ridge width and height changes 4 months following extraction and alveolar ridge preservation at sites that undergo immediate post-extraction socket expansion or no immediate post-extraction ridge width change. Patients of the Graduate Periodontics Clinic at Marquette University School of Dentistry scheduled for extraction, bone graft and resorbable membrane will be recruited for this study.

After providing informed consent and prior to local anesthesia and extraction, the following parameters will be recorded: age, gender, race, medical history, medications, tooth site, reason for extraction and tooth mobility. Gingival width will be recorded prior to local anesthesia and extraction, and at 4 months. Gingival thickness will be recorded after local anesthesia and prior to extraction, and at 4 months. Buccolingual ridge width and ridge height will be recorded immediately before, immediately after extraction, and at 4 months. Immediately after extraction, the following measurements will be recorded: buccal bone thickness, number of roots, root length and width, instruments used for extraction, need for flap elevation, duration of extraction, anesthetic amount, type and approach, and operator experience.

• Study Type: Observational
• Enrollment (Estimated): 160

Contacts and Locations

• Study Contact: Name: Vrisiis Kofina, DDS, MS; Phone Number: 4142886521; Email: vrisiis.kofina@marquette.edu
• Study Contact Backup: Name: Samah Rady, DDS; Phone Number: 9497962173; Email: samahsy.rady@marquette.edu

Study Locations

• United States
  • Wisconsin
    • Milwaukee, Wisconsin, United States, 53233
      • Recruiting
      • Marquette University School of Dentistry Graduate Periodontics Clinic
      • Contact: Vrisiis Kofina, DDS, MS; Phone Number: 4142886521; Email: vrisiis.kofina@marquette.edu
      • Contact: Arndt Guentsch, DMD, PhD, MHBA, MS; Phone Number: 4142886089; Email: arndt.guentsch@marquette.edu
      • Principal Investigator: Vrisiis Kofina, DDS, MS

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Patients scheduled for tooth extraction and alveolar ridge preservation (bone graft and membrane) in the Graduate Periodontics Clinic at Marquette University School of Dentistry.

Description

Inclusion Criteria:

• Adult patients (18-75 years)
• Good general health (controlled conditions)
• Controlled periodontal disease
• Scheduled for single tooth extraction with bone graft placement and resorbable membrane
• Tooth to be extracted must have adjacent teeth
• Socket wall integrity

Exclusion Criteria:

• Smoking
• Pregnancy
• Active periodontal disease
• Systemic conditions that affect healing
• Lack of socket wall integrity (bone loss ≥50 %) prior to extraction, teeth with severe infection requiring pre-extraction antibiotic treatment to control infection), and contraindications for tooth extraction.

Study Plan

How is the study designed?

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Non-molar sites with immediate post-extraction ridge expansion; Non-molar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.	Other: observational study; Observational study; alveolar ridge preservation
Non-molar sites with no immediate post-extraction ridge width change; Non-molar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.	Other: observational study; Observational study; alveolar ridge preservation
Molar sites with immediate post-extraction ridge expansion; Molar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.	Other: observational study; Observational study; alveolar ridge preservation
Molar sites with no immediate post-extraction ridge width change; Molar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.	Other: observational study; Observational study; alveolar ridge preservation

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Buccolingual ridge width	Buccolingual ridge width will be measured through a stent via ridge mapping calipers. The measurement locations will be at 1mm, 3mm and 5mm from the midbuccal crest. The same measurements will be recorded at all selected time points.	(1) After local anesthesia and before extraction, (2) immediately after extraction and (3) 4 months after extraction and alveolar ridge preservation
Ridge height	Ridge height will be measured through a stent via a periodontal probe as the distance between bone and predetermined landmarks on the stent. The measurement locations will be mesial buccal, midbuccal, distal buccal, mesial lingual, midlingual and distal lingual. The same measurements will be recorded at all selected time points.	(1) After local anesthesia and before extraction, (2) immediately after extraction and (3) 4 months after extraction and alveolar ridge preservation

Collaborators and Investigators

• Sponsor: Marquette University
• Investigators: Principal Investigator: Vrisiis Kofina, DDS, MS, Marquette University

Study record dates

Study Major Dates

• Study Start (Actual): October 8, 2025
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): October 1, 2027

Study Registration Dates

• First Submitted: October 1, 2024
• First Submitted That Met QC Criteria: October 1, 2024
• First Posted (Actual): October 3, 2024

Study Record Updates

• Last Update Posted (Actual): November 17, 2025
• Last Update Submitted That Met QC Criteria: November 13, 2025
• Last Verified: November 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Investigative Techniques; Methods; Observation
• Other Study ID Numbers: HR-4787

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No