FILIP: Fat Intake, Inflammation and LIPids (FILIP)

February 2, 2026 updated by: Göteborg University

Low-grade inflammation is involved in the pathogenesis of type 2 diabetes and cardiovascular disease. Increasing evidence suggests that dietary intake may be involved in the inflammatory process. How nutritional composition of the diet affects the inflammatory response is however not well understood.

The aim of this project is to study if intake of three different fat sources induce different effects on inflammation markers, blood lipids, blood glucose and the microbiota.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

25

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Sweden
      • Gothenburg, Sweden, 40530
        • University of Gothenburg

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Age 18-60
  • Willing to eat the study diet

Exclusion Criteria:

  • malabsorption-related condition
  • contraindications to consume a high fat diet
  • intolerance to any foods used in the study (e.g. cow's milk, egg, gluten)
  • established cardiovascular disease, diabetes or cancer
  • current use of medication known to affect lipid metabolism (e.g. statins) or inflammation (e.g. NSAID, glucocorticoids).
  • hemoglobin <100 g/L
  • ongoing pregnancy or lactation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Sequence 1: Rapeseed oil, butter, coconut oil
Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals
Other: Rapeseed oil
During 1 week, 46 % of total energy intake will come from rapeseed oil, using pre-prepared and blinded meals.
Other: Butter
During 1 week, 46 % of total energy intake will come from butter, using pre-prepared and blinded meals.
Other: Coconut oil
During 1 week, 46 % of total energy intake will come from coconut oil, using pre-prepared and blinded meals.
Experimental: Sequence 2: Rapeseed oil, coconut oil, butter
Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals
Other: Rapeseed oil
During 1 week, 46 % of total energy intake will come from rapeseed oil, using pre-prepared and blinded meals.
Other: Butter
During 1 week, 46 % of total energy intake will come from butter, using pre-prepared and blinded meals.
Other: Coconut oil
During 1 week, 46 % of total energy intake will come from coconut oil, using pre-prepared and blinded meals.
Experimental: Sequence 3: Butter, coconut oil , rapeseed oil
Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals
Other: Rapeseed oil
During 1 week, 46 % of total energy intake will come from rapeseed oil, using pre-prepared and blinded meals.
Other: Butter
During 1 week, 46 % of total energy intake will come from butter, using pre-prepared and blinded meals.
Other: Coconut oil
During 1 week, 46 % of total energy intake will come from coconut oil, using pre-prepared and blinded meals.
Experimental: Sequence 4: Butter, rapeseed oil, coconut oil
Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals
Other: Rapeseed oil
During 1 week, 46 % of total energy intake will come from rapeseed oil, using pre-prepared and blinded meals.
Other: Butter
During 1 week, 46 % of total energy intake will come from butter, using pre-prepared and blinded meals.
Other: Coconut oil
During 1 week, 46 % of total energy intake will come from coconut oil, using pre-prepared and blinded meals.
Experimental: Sequence 5: Coconut oil, rapeseed oil, butter
Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals
Other: Rapeseed oil
During 1 week, 46 % of total energy intake will come from rapeseed oil, using pre-prepared and blinded meals.
Other: Butter
During 1 week, 46 % of total energy intake will come from butter, using pre-prepared and blinded meals.
Other: Coconut oil
During 1 week, 46 % of total energy intake will come from coconut oil, using pre-prepared and blinded meals.
Experimental: Sequence 6: Coconut oil, butter, rapeseed oil
Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals
Other: Rapeseed oil
During 1 week, 46 % of total energy intake will come from rapeseed oil, using pre-prepared and blinded meals.
Other: Butter
During 1 week, 46 % of total energy intake will come from butter, using pre-prepared and blinded meals.
Other: Coconut oil
During 1 week, 46 % of total energy intake will come from coconut oil, using pre-prepared and blinded meals.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Total cholesterol
Time Frame: Baseline and 1 week
Baseline and 1 week
hs-CRP
Time Frame: Baseline and 1 week
High sensitivity C-reactive Protein
Baseline and 1 week

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Inflammation markers
Time Frame: Baseline and 1 week
Eg. GlycA, IL6, TNF-a
Baseline and 1 week
Blood lipid propfile
Time Frame: Baseline and 1 week
Blood lipids and their subfractions, lipoproteins, apolipoproteins
Baseline and 1 week
Glucose
Time Frame: Continuous during 1 week
Glucose, measured by continuous blood glucose monitoring
Continuous during 1 week
Microbiota
Time Frame: Baseline and 1 week
Change in gut microbial composition and diversity (alpha- and beta).
Baseline and 1 week

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Göteborg University

Collaborators

Chalmers University of Technology

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 8, 2025

Primary Completion (Actual)

December 17, 2025

Study Completion (Actual)

December 17, 2025

Study Registration Dates

First Submitted

October 10, 2024

First Submitted That Met QC Criteria

October 10, 2024

First Posted (Actual)

October 15, 2024

Study Record Updates

Last Update Posted (Actual)

February 4, 2026

Last Update Submitted That Met QC Criteria

February 2, 2026

Last Verified

April 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2024-03117-01

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

IPD Plan Description

It would depend on ethical permission to share the IPD.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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