Feasibility of At-Home Chair-Based Resistance Band Training to Improve Balance, Strength, and Bone Density in Older Adults (ChaREx)

Feasibility of 24-Weeks of At-Home Chair-Based Resistance Band Training to Improve Balance, Strength, and Bone Density in Older Adults (ChaREx Study)

The purpose of this study is to determine the feasibility of implementing a 24-week at-home chair-based resistance band training intervention, to determine effectiveness of a the a 24-week at-home chair-based resistance band training intervention in improving body composition and to determine the effectiveness of a 24-week at-home chair-based resistance band training intervention in improving physical performance in adults 50 years and older, receiving care at the UT Physicians Center for Healthy Aging.

Study Overview

• Status: Not yet recruiting
• Conditions: Sarcopenic Obesity
• Intervention / Treatment: Device: THERABand resistance exercise bands

• Study Type: Interventional
• Enrollment (Estimated): 40
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Nahid Rianon, MBBS,DrPH; Phone Number: (713) 500-5106; Email: Nahid.J.Rianon@uth.tmc.edu
• Study Contact Backup: Name: Jude des Bordes, MBChB, DrPH; Phone Number: (713) 500-6029; Email: Jude.K.desBordes@uth.tmc.edu

Study Locations

• United States
  • Texas
    • Houston, Texas, United States, 77479
      • The University of Texas Health Science Center at Houston
      • Contact: Jude des Bordes, MBChB, DrPH; Phone Number: (713) 500-6029; Email: Jude.K.desBordes@uth.tmc.edu
      • Contact: Nahid Rianon, MBBS,DrPH; Phone Number: 713-500-5106; Email: Nahid.J.Rianon@uth.tmc.edu

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• English-speaking
• receive care at the UT Physician Center for Healthy Aging

Exclusion Criteria:

• inability to provide informed consent on their own
• presence of obvious signs of cognitive decline
• a diagnosis of dementia and inability to come to the clinic for the scheduled study visits.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Chair-based resistance band training	Device: THERABand resistance exercise bands; The training will be performed using THERABand resistance exercise bands.Participants will be instructed to perform the exercises twice per week at home, for the 24 weeks duration. Each exercise session will entail 1 set of 15 repetitions of 9 different exercises

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Feasibility as assessed by the number of people who are able to follow the prescribed exercise regimen at least 50 percent of the time	end of study (24 weeks from baseline)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in body fat	This will be assessed using the handheld bioelectrical impedance analysis (BIA) device (Omron HBF-510)	baseline,6-months
Change in bone mineral density (BMD) of the femoral neck and lumbar spine	This will be assessed by the Dual energy x-ray absorptiometry (DXA)	baseline, 1 year from baseline
Handgrip strength	This will be assessed using a validated handgrip dynamometer	baseline
Handgrip strength	This will be assessed using a validated handgrip dynamometer	1-month
Handgrip strength	This will be assessed using a validated handgrip dynamometer	3-months
Handgrip strength	This will be assessed using a validated handgrip dynamometer	6-months
60-second balance as assessed by the the Zibrio Stability Pro scale	This is determined by the patient standing on the Zibrio Stability Pro Scale unassisted for one minute and will be measured on a scale of 1 to 9 with lower scores indicating higher risk of fall	Baseline
60-second balance as assessed by the the Zibrio Stability Pro scale	This is determined by the patient standing on the Zibrio Stability Pro Scale unassisted for one minute and will be measured on a scale of 1 to 9 with lower scores indicating higher risk of fall	1-month
60-second balance as assessed by the the Zibrio Stability Pro scale	This is determined by the patient standing on the Zibrio Stability Pro Scale unassisted for one minute and will be measured on a scale of 1 to 9 with lower scores indicating higher risk of fall	3-months
60-second balance as assessed by the the Zibrio Stability Pro scale	This is determined by the patient standing on the Zibrio Stability Pro Scale unassisted for one minute and will be measured on a scale of 1 to 9 with lower scores indicating higher risk of fall	6-months
walking gait speed	Gait speed will be assessed over a 6-meter distance measured within a private clinic space. The participant will be instructed to walk at their normal walking pace (as if they were walking throughout the house) and the distance/time will be converted to meters/second.Faster walking speed is related to reduced fall-risk, improved physical function, and greater survival .	Baseline
walking gait speed	Gait speed will be assessed over a 6-meter distance measured within a private clinic space. The participant will be instructed to walk at their normal walking pace (as if they were walking throughout the house) and the distance/time will be converted to meters/second.Faster walking speed is related to reduced fall-risk, improved physical function, and greater survival .	1-month
walking gait speed	Gait speed will be assessed over a 6-meter distance measured within a private clinic space. The participant will be instructed to walk at their normal walking pace (as if they were walking throughout the house) and the distance/time will be converted to meters/second.Faster walking speed is related to reduced fall-risk, improved physical function, and greater survival .	3-months
walking gait speed	Gait speed will be assessed over a 6-meter distance measured within a private clinic space. The participant will be instructed to walk at their normal walking pace (as if they were walking throughout the house) and the distance/time will be converted to meters/second.Faster walking speed is related to reduced fall-risk, improved physical function, and greater survival .	6-months
Blood level of pro-collagen type 1 N-telopeptide (P1NP)	P1NP is a metabolic marker of bone formation, indicates status of bone loss and a stable or decreased level will be indicating improved metabolism	Baseline
Blood level of pro-collagen type 1 N-telopeptide (P1NP)	P1NP is a metabolic marker of bone formation, indicates status of bone loss and a stable or decreased level will be indicating improved metabolism	6 months
Frailty as assessed by the Fried criteria	This consists of 5 items (unintentional weight loss, weakness [low grip strength], slowness low, self-reported exhaustion and low physical activity). Patients who meet 1or 2 of the criteria are described as pre-frail and 3 or more as frail.	Baseline
Frailty as assessed by the Fried criteria	This consists of 5 items (unintentional weight loss, weakness [low grip strength], slowness low, self-reported exhaustion and low physical activity). Patients who meet 1or 2 of the criteria are described as pre-frail and 3 or more as frail.	1-month
Frailty as assessed by the Fried criteria	This consists of 5 items (unintentional weight loss, weakness [low grip strength], slowness low, self-reported exhaustion and low physical activity). Patients who meet 1or 2 of the criteria are described as pre-frail and 3 or more as frail.	3-months
Frailty as assessed by the Fried criteria	This consists of 5 items (unintentional weight loss, weakness [low grip strength], slowness low, self-reported exhaustion and low physical activity). Patients who meet 1or 2 of the criteria are described as pre-frail and 3 or more as frail.	6-months

Collaborators and Investigators

• Sponsor: The University of Texas Health Science Center, Houston
• Investigators: Principal Investigator: Nahid Rianon, MBBS, DrPH, The University of Texas Health Science Center, Houston

Study record dates

Study Major Dates

• Study Start (Estimated): January 1, 2025
• Primary Completion (Estimated): March 31, 2026
• Study Completion (Estimated): September 30, 2026

Study Registration Dates

• First Submitted: November 1, 2024
• First Submitted That Met QC Criteria: November 1, 2024
• First Posted (Estimated): November 4, 2024

Study Record Updates

• Last Update Posted (Estimated): November 4, 2024
• Last Update Submitted That Met QC Criteria: November 1, 2024
• Last Verified: November 1, 2024

More Information

Terms related to this study

• Keywords: chair-based resistance band exercise
• Other Study ID Numbers: HSC-MS-24-0485

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: Yes
• product manufactured in and exported from the U.S.: No