- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05437952
Metabolic and Molecular Responses Under the Effect of Taurine Supplementation With and Without Multicomponent Training
Metabolic and Molecular Responses Under the Effect of Taurine Supplementation With and Without Multicomponent Training in Elderly Women With Sarcopenic Obesity Using the Metabolomics Approach
Study Overview
Status
Conditions
Detailed Description
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Gabriela F Abud, M.Sc.
- Phone Number: +5516997940181
- Email: gabriela.abud@usp.br
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- BMI between 30 and 40kg/m²;
- Appendicular lean mass below 15 kg;
- Dynamometry below the cutoff point adjusted for sex and BMI (less than or equal to 21kg);
- "Sit and stand" test below the cut-off point adjusted for the age group, considering the number of repetitions in 30 seconds;
- Present medical certificate to perform physical exercise
Exclusion Criteria:
- alcoholics
- smokers;
- with any disease that prevents the practice of physical activity;
- medical impediment to the practice of physical exercise throughout the study;
- infectious diseases;
- coronary diseases;
- chronic kidney diseases;
- undergoing nutritional monitoring or weight loss treatment;
- score ≤13 for cognitive screening on the Mini-Mental State Examination (MMSE), suggested by Bertolucci et al. (1994).
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Taurine and Exercise (Tau+Ex)
Participants who will receive 3g of taurine supplementation associated with physical training in the period of 16 weeks.
|
Participants will receive 3g of taurine to be supplemented in the morning in single-dose capsules. The intervention will last 16 weeks. Pshysical exercise Participants will perform a multicomponent type workout that explores strength, aerobic and balance capacities with load progression every 15 days. The sessions will last 60 minutes each, being held three times a week with a day of rest in between. The intervention will last 16 weeks |
Experimental: Placebo and Exercise (PL+Ex)
Participants who will receive 3g of placebo supplementation associated with physical training in the period of 16 weeks.
|
Participants will receive 3g of placebo to be supplemented in the morning in single-dose capsules. The intervention will last 16 weeks. Pshysical exercise Participants will perform a multicomponent type workout that explores strength, aerobic and balance capacities with load progression every 15 days. The sessions will last 60 minutes each, being held three times a week with a day of rest in between. The intervention will last 16 weeks. |
Experimental: Taurine (Tau)
Participants who will receive 3g of taurine supplementation in the period of 16 weeks.
|
Participants will receive 3g of taurine to be supplemented in the morning in single-dose capsules.
The intervention will last 16 weeks.
|
Placebo Comparator: Placebo (PL)
Participants who will receive 3g of placebo supplementation in the period of 16 weeks.
|
Participants will receive 3g of placebo to be supplemented in the morning in single-dose capsules.
The intervention will last 16 weeks.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Metabolomic Profile
Time Frame: 16 weeks
|
Changes in metabolites and lipids of the biological sample investigated through the metabolomics approach.
|
16 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Gene expressions in the subcutaneous white adipose tissue (scWAT). RNA (mRNA) levels of infammatory gene markers.
Time Frame: 16 weeks
|
Changes in the expression of genes related to the inflammatory process that will be analyzed: C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-15 (IL-15), necrosis factor tumor-α (TNF-α), nuclear factor-κβ (NFκβ) and adiponectin (ADIPOQ).
|
16 weeks
|
Gene expressions in the subcutaneous white adipose tissue (scWAT). RNA (mRNA) levels of oxidative stress genes markers.
Time Frame: 16 weeks
|
Changes in the expression of genes related to oxidative stress that will be analyzed: superoxide dismutase (SOD1), glutathione peroxidase (GPx1) and catalase (CAT).
|
16 weeks
|
Gene expressions in the subcutaneous white adipose tissue (scWAT). RNA (mRNA) levels of lipid oxidation genes markers.
Time Frame: 16 weeks
|
Changes expression of genes related to the lipid oxidation process that will be analyzed: sirtuin-1 (SIRT-1), forkhead O 1 (FOXO1), peroxisome proliferator 1 alpha (PGC-1α), peroxisomal proliferator alpha type (PPARα).
|
16 weeks
|
Functional ability tests: Six-minute walk test (minutes)
Time Frame: 16 weeks
|
Changes in functional capacity assessed by: six-minute walk test.
|
16 weeks
|
Functional ability tests: forearm flexion test (seconds)
Time Frame: 16 weeks
|
Changes in functional capacity assessed by: forearm flexion test.
|
16 weeks
|
Functional ability tests: muscle strength (dynamometer) - highest peak force (KGF)
Time Frame: 16 weeks
|
Changes in functional capacity assessed by: muscle strength (dynamometer).
|
16 weeks
|
Functional ability tests: chair sit-up test. (seconds)
Time Frame: 16 weeks
|
Changes in functional capacity assessed by: chair sit-up test.
|
16 weeks
|
Indirect calorimetry assessment
Time Frame: 16 weeks
|
Changes in resting metabolic rate (RMR) evaluated pre and post intervention by indirect calorimetry.
|
16 weeks
|
Body composition changes (%)
Time Frame: 16 weeks
|
Changes in % fat-free mass and fat mass evaluated pre, during and post intervention by iDEXA.
|
16 weeks
|
Anthropometric measurements (Body weight)
Time Frame: 16 weeks
|
Changes in body weight (kilograms - Kg) pre and post intervention.
|
16 weeks
|
Anthropometric - height assessment (meters)
Time Frame: 16 weeks
|
Height measured in meters
|
16 weeks
|
Anthropometric measurements (Circumferences)
Time Frame: 16 weeks
|
Changes in waist, abdominal, and hip circumferences (centimeters) evaluated pre and post intervention.
|
16 weeks
|
Others changes in metabolic parameters
Time Frame: 16 weeks
|
Changes in total cholesterol, triglycerides, HDL-cholesterol and LDL-c, fasting glucose and insulin sensitivity evaluated pre and post intervention.
|
16 weeks
|
Food Intake changes
Time Frame: 16 weeks
|
Changes in food consumption.
It will be evaluated through 24-hour food records.
The professional software Dietbox will be used to evaluate the total consumption of energy and macronutrients.
Evaluated pre, during and post intervention.
|
16 weeks
|
Changes in Plasma Taurine Concentration
Time Frame: 16 weeks
|
Changes in Plasma Taurine Concentration.
Plasma taurine will be determined by high performance liquid chromatography (HPLC).
|
16 weeks
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Ellen C De Freitas, Ph.D., University of São Paulo, School of Physical Education and Sports of Ribeirão Preto
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- taurine_training_metabolomics
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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