Effect of a Plant Based Nootropic on Perceptual Decision Making.

November 13, 2024 updated by: Dr Andrea Utley, University of Leeds

Effect of a Plant-based Nootropic Supplement on Perceptual Decision-making and Brain Network Interdependencies: a Randomised, Double-blinded and Placebo-controlled Study.

Nootropics are a group of medicinal substances purported to improve important cognitive functions such as learning, focus and memory. Many of these substances have demonstrated beneficial effects on cognitive performance and overall health. However, a thorough understanding of how these substances and their synergistic effects in the form of a supplement may benefit fundamental brain processes is currently lacking. In the current study, we will investigate the effects of a plant-based, nootropic supplement (https://uk.mindlabpro.com/) on perceptual decision-making (i.e. the ability to make rapid decisions based on sensory stimuli) in healthy adult participants.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Participants will perform a computerised cognitive task assessing their perceptual decision-making pre- and post- 60 days of continuous supplementation with either a plant-based nootropic supplement (Mind Lab pro) or placebo. During testing, electroencephalography (EEG) signals will be captured simultaneously.

Study Type

Interventional

Enrollment (Actual)

37

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Eligibility screening of participants was guided by the following inclusion criteria: (i) be between 20-59 years old, (ii) be right-handed and (iii) be able to cease taking other dietary supplements for two months.

Exclusion Criteria:

  • Exclusion criteria included: (i) currently consuming a nootropic supplement, (ii) any known musculoskeletal, or neurological medical conditions or cognitive impairments (iii) have a known diagnosis of epilepsy/history of seizures and (iv) have a known hearing or visual condition that affects daily life function.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Experimental group
This group will receive the nootropic supplement for 60 days.
Dietary supplement: Nootropics (ginkgo biloba, nicergoline, piracetam, or others)
Commercially available product: Mind lab pro
Behavioral: Perceptual decision-making performance
A computerised cognitive task involving rapid visual categorisation of images
Device: Electroencephalography
Brain signals are recorded from a 64 channel EEG system during the cognitive task
Placebo Comparator: Control group
This group will receive a placebo supplement for 60 days
Behavioral: Perceptual decision-making performance
A computerised cognitive task involving rapid visual categorisation of images
Device: Electroencephalography
Brain signals are recorded from a 64 channel EEG system during the cognitive task
Dietary supplement: Placebo
A cellulose commonly used as a bulking agent in supplement products

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Perceptual decision-making performance
Time Frame: Pre- and post- 60 days of supplementation
Choice accuracy and reaction times
Pre- and post- 60 days of supplementation

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Brain network interdependencies
Time Frame: Pre- and post- 60 days of supplementation
Patterns extracted from brain signals using electroencephalography
Pre- and post- 60 days of supplementation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Leeds

Investigators

  • Principal Investigator: Ioannis Delis, University of Leeds

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 23, 2023

Primary Completion (Actual)

March 6, 2024

Study Completion (Actual)

June 1, 2024

Study Registration Dates

First Submitted

November 13, 2024

First Submitted That Met QC Criteria

November 13, 2024

First Posted (Estimated)

November 14, 2024

Study Record Updates

Last Update Posted (Estimated)

November 14, 2024

Last Update Submitted That Met QC Criteria

November 13, 2024

Last Verified

November 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • AUtley

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

No further investigations will take place using this data with anyone outside of the current research group

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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