Clinical and Laboratory Profile of Myasthenia Gravis in Children At Sohag University Hospitals

January 13, 2025 updated by: Menna Mohamed Sedik, Sohag University
This study includes clinical and laboratory studies of patients with Myathenia gravis at Sohag Neurology outpatient clinic of pediatric department

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

All patients in this study were subjected to the followings:

(A) Clinical history focusing on: Sociodemographic data: age, gender , residence,and degree of consanguinity. Full neurodevelopmental history: neurological evaluation Family history. Mode of delivery

(B) Thorough clinical examination: General examination including general look, vital signs and anthropometric measurements.

Scale system include gross motor function and muscle power(Quantitative Myasthenia Gravis Scale) [36] detailed neurological examination including motor ,sensory and reflexes. (C) Investigations:

  1. Electrophysiological testing:

    EMG : is especially useful in diagnosis of seronegative MG and congenital myasthenic syndromes.

    NCS: including repetitive nerve stimulation test (r NST)

  2. laboratory studies: Serology. Detection of antibodies to the AChR supports the diagnosis of JMG. In young children where AChR antibodies are negative this can lead to difficulty in differentiating from CMS.

    Thyroid function tests :

  3. Imaging:

    CT chest: Although thymoma in children is rare, the thymus must be imaged once JMG has been diagnosed.

  4. molecular studies (when possible).

Study Type

Observational

Enrollment (Estimated)

20

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Egypt
      • Sohag, Egypt
        • Sohag University Hospital
      • Sohag, Egypt
        • Sohag University
        • Contact:
          • Menna Mohamed Resident doctor of pediatric at El Helal hospital, Resident doctor of pediatric
          • Phone Number: 01011707915 01011707915
          • Email: Mena011195@med.sohag.edu.eg

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients:

Patients diagnosed with myasthenia gravis at the pediatric out patient clinic by clinical charactristics ,nerve study and laboratory data will be elligable for the study.

Description

Inclusion Criteria:

  • All patients from 1 month to 16 years confirmed diagnosis of myasthenia gravis by neurological and laboratory data.

Care giver accept to participate in the study.

Exclusion Criteria:

  • Failure to obtain informed consent. Other neurological and neuromuscular disorders. Age above 16 years.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
One group of patients againg one month to 16 years old with myasthenia gravis

Patients diagnosed with myasthenia gravis at the pediatric out patient clinic by clinical charactristics ,nerve study and laboratory data will be elligable for the study.

Inclusion Criteria:

  • All patients from 1 month to 16 years confirmed diagnosis of myasthenia gravis by neurological and laboratory data.
  • Care giver accept to participate in the study.
Diagnostic test: All patients in this study were subjected to the followings: (A) Clinical history focusing on: Sociodemographic data: age, gender , residence,and degree of consanguinity. Full neurodevelopmental his

Thorough clinical examination:

1. General examination including general look, vital signs and anthropometric measurements.

2. Scale system include gross motor function and muscle power(Quantitative Myasthenia Gravis Scale) [36] 3. detailed neurological examination including motor ,sensory and reflexes. (C) Investigations:

  1. Electrophysiological testing:

    EMG : is especially useful in diagnosis of seronegative MG and congenital myasthenic syndromes.

    NCS: including repetitive nerve stimulation test (r NST)

  2. laboratory studies:

    • Serology. Detection of antibodies to the AChR supports the diagnosis of JMG. In young children where AChR antibodies are negative this can lead to difficulty in differentiating from CMS.
    • Thyroid function tests :

  3. Imaging:

    • CT chest: Although thymoma in children is rare, the thymus must be imaged once JMG has been diagnosed.

  4. molecular studies (when possible).
Diagnostic test: EMG ,rNST,Ach R antibodies & thyroid function

C) Investigations:

  1. Electrophysiological testing:

    EMG : is especially useful in diagnosis of seronegative MG and congenital myasthenic syndromes.

    NCS: including repetitive nerve stimulation test (r NST)

  2. laboratory studies:

    • Serology. Detection of antibodies to the AChR supports the diagnosis of JMG. In young children where AChR antibodies are negative this can lead to difficulty in differentiating from CMS.
    • Thyroid function tests :

  3. Imaging:

    • CT chest: Although thymoma in children is rare, the thymus must be imaged once JMG has been diagnosed.

  4. molecular studies (when possible).

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Clinical and laboratory profile of patients with myasthenia gravis at Sohag Neurology Outpatient clinic of pediatric department
Time Frame: Follow up for 6 months
All patients with myasthenia gravis in this study focusing on clinical and laboratory profile at Sohag Neurology outpatient clinic.
Follow up for 6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sohag University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

February 1, 2025

Primary Completion (Estimated)

May 1, 2025

Study Completion (Estimated)

August 1, 2025

Study Registration Dates

First Submitted

December 11, 2024

First Submitted That Met QC Criteria

January 13, 2025

First Posted (Actual)

March 25, 2025

Study Record Updates

Last Update Posted (Actual)

March 25, 2025

Last Update Submitted That Met QC Criteria

January 13, 2025

Last Verified

June 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Soh-Med-24-09-03MS

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Myasthenia Gravis in Children

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Congo

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe