Evaluation of Post-operative Pain During Retreatment in Different Visits

Evaluation of Post Operative Pain in Non-surgical Endodontic Retreatment in Single vs Multiple Visits

Endodontic retreatment is performed to alleviate symptoms of recurring infection, post-treatment disease after primary endodontic therapy. Retreatment can be performed in either single or multiple visits. and have their own implications. it is important to compare the patient response and post-op pain after single vs multi-visit reendo treatment.

Study Overview

• Status: Completed
• Conditions: Post Operative Pain
• Intervention / Treatment: Procedure: single visit re-endo; Procedure: multi visit re-endo

Detailed Description

Introduction:

Treating endodontic failure cases has always been a challenge for the clinician due to the complex nature of disease which includes resistant microorganisms, iatrogenic errors and cleaning and shaping of un-instrumented areas. Endodontic retreatment can be done in either single or multiple visits. Multiple visits have the added advantage of placement of intracanal medicament resulting in decreased bacterial load and reduced pain, whereas single visit endodontic retreatment reduces chances of inter appointment microbial contamination. This study aims to evaluate post operative pain among both groups.

Objective:

To evaluate frequency of post-operative pain in endodontic retreatment cases after single vs multiple (two) visits root canal therapy.

Materials and Methods:

STUDY SETTING: Department of Operative Dentistry, AFID Rawalpindi.

• Study Type: Interventional
• Enrollment (Actual): 116
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Pakistan
  • Punjab
    • Rawalpindi, Punjab, Pakistan, 64000
      • Armed Forces Institute of Dentistry

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Patients with unremarkable/ noncontributory medical history
• Age range between 15-45 years
• Cases of failed endodontic treatment resulting from inadequate root filling
• No systemic disease
• No periodontal disease

Exclusion Criteria:

• Patients having teeth with periodontal pathology
• root fractures
• Immature root apices
• Endodontic posts
• Root perforations
• Immunocompromised health were excluded from the study.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Single visit group; Endodontic retreatment in this group will be performed in a single visit. Initiated, deobturated, disinfection done and completed during the same visit.	Procedure: single visit re-endo; In this group, a single visit re-endodontic treatment will be performed and completed in the same visit, including all the steps.
Active Comparator: Multi visit Group; Endodontic retreatment in this group will be performed in more than 1 visit. The retreatment will be initiated, deobturated, and disinfection done and completed in second or third visits..	Procedure: multi visit re-endo; In this group, a multi-visit re-endodontic treatment will be performed and completed over different visits, including all the steps.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Post operative pain after re-endo	Post-operative pain after single vs multi visit re-endo treatment to be compared. The patients will be guided in detail about the procedure and how to document their response to the treatment. The Visual Analog Scale (VAS). numbered from 0-10, with 0 being no pain, 1 - 3: mild pain, 4-6: moderate pain, and 7-10 severe pain, will be used to record pain experienced by the patients and notified to the investigator.	6 hours - 72 hours

Collaborators and Investigators

• Sponsor: Armed Forces Institute of Dentistry, Pakistan

Study record dates

Study Major Dates

• Study Start (Actual): April 1, 2022
• Primary Completion (Actual): May 1, 2023
• Study Completion (Actual): July 1, 2023

Study Registration Dates

• First Submitted: June 1, 2025
• First Submitted That Met QC Criteria: June 9, 2025
• First Posted (Actual): June 10, 2025

Study Record Updates

• Last Update Posted (Actual): June 10, 2025
• Last Update Submitted That Met QC Criteria: June 9, 2025
• Last Verified: June 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pain; Neurologic Manifestations; Postoperative Complications; Pathologic Processes; Pain, Postoperative
• Other Study ID Numbers: Re-endo pain comparison

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No