Efficacy of Olfactive Training on Loss of Smell and Taste Caused by SARS CoV2 COVID-19 (Covid-Smell) (COVID-SMELL)

September 29, 2025 updated by: Centre Hospitalier Universitaire de la Guadeloupe

Efficacy of Olfactive Training on Loss of Smell and Taste Caused by SARS CoV2 (Covid-Smell)

The purpose of this study is to evaluate efficiency of two months of olfactive training on olfactory and taste loss secondary to covid-19. We will compare 2 groups : olfactive training group versus no olfactive training group.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The purpose of this study is to evaluate efficiency of two months of olfactive training on olfactory and taste loss secondary to covid-19. We will compare 2 groups : olfactive training group versus no olfactive training group.

Study Type

Interventional

Enrollment (Actual)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Guadeloupe
      • Pointe-à-Pitre, Guadeloupe, 97159
        • CHU de la Guadeloupe

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • SARS-CoV-2 infection suspect or confirmed
  • supported by CHU Guadeloupe
  • with brutal olfactory or taste loss
  • affiliated or beneficiary of a social security scheme
  • informed consent signed

Exclusion Criteria:

  • recent rhinosinusitis, less than 6 months
  • lingual pathology
  • communication disorder
  • Patients subject to a justice safeguard
  • Allergy to several spices that are part of the rehabilitation set
  • Pregnant or breastfeeding women
  • Absence of signed consent

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: olfactory training arm
with a daily olfactory training during 2 month
Other: Olfactory rehabilitation consists of smelling a series of spices every day for 2 months

Olfactory rehabilitation consists of smelling a series of spices every day for 2 months: vanilla, coffee, dill, thyme, cinnamon, cloves, lavender, coriander, light vinegar, mint, and cumin.

This rehabilitation is based on the protocols proposed by SFORL (French ORL society) and Oleszkiewicz et al.8

Allergies to certain spices will be noted at the start of the study:

  • in known allergy: change by another spice which belongs to the same chemical category.
  • in case of allergies to several scents: patient is not included in the study.
  • in case of allergy appearing during participation: clinical evaluation by ENT, change by another spice which belongs to the same chemical category.
  • in case of allergies to several scents occuring during participation: patient is excluded from the study.
No Intervention: no olfactory training

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Taste and Smell Survey (TSS).
Time Frame: Baseline and 2 months
Patients will have this auto evaluation scale at the inclusion (D0) and 2 month after inclusion (D60).
Baseline and 2 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Sniffin' stick test :
Time Frame: 2 month
The Sniffin' Stick Test assesses the sense of smell by measuring odor detection threshold, discrimination, and identification, and is used for diagnosing and monitoring olfactory disorders.
2 month
Olfaction and taste evolution evaluated with a daily visual scale
Time Frame: Every day from inclusion to 2 months
Visual analogue scale from 0 to 10 to assess dysosmia and dysgeusia, with 0 indicating normal function and 10 indicating complete deficit.
Every day from inclusion to 2 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier Universitaire de la Guadeloupe

Investigators

  • Principal Investigator: suzy Duflo, MD PhD, CHU de la Guadeloupe

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 18, 2020

Primary Completion (Actual)

March 9, 2022

Study Completion (Actual)

March 9, 2022

Study Registration Dates

First Submitted

September 22, 2025

First Submitted That Met QC Criteria

September 22, 2025

First Posted (Estimated)

September 24, 2025

Study Record Updates

Last Update Posted (Estimated)

October 2, 2025

Last Update Submitted That Met QC Criteria

September 29, 2025

Last Verified

September 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PAP_RI2_2020/17
  • 2020-A02606-33 (Registry Identifier: ANSM)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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