Autogenous Tooth Bone Graft for Alveolar Socket Preservation (ATBG)

"Autogenous Tooth Bone Graft for Alveolar Socket Preservation: A CBCT-Based Clinical Trial With 6-Month Follow-Up"

The purpose of this clinical experiment is to assess how well autogenous tooth bone grafting preserves the alveolar socket after surgical tooth extraction. Before being inserted into the socket, the graft is made from the patient's own extracted tooth and ground into a particle. Twenty Yemeni patients who needed their teeth extracted are included in the trial, and they will be followed up with clinical and radiographic procedures using cone-beam computed tomography (CBCT) for six months. The primary objective is to ascertain whether the autogenous dental bone graft can preserve the height, width, and density of alveolar bone, offering a secure, affordable, and biocompatible substitute for traditional grafting materials.

Study Overview

• Status: Active, not recruiting
• Conditions: Alveolar Bone Grafting; Bone Regeneration Following Wisdom Teeth Extraction; Tooth Extraction Site Healing
• Intervention / Treatment: Biological: "Autogenous Tooth Bone Graft"

Detailed Description

This interventional clinical study investigates the role of autogenous tooth bone graft in alveolar socket preservation after surgical tooth extraction. The extracted tooth is cleaned, dried, processed into particulate graft material manually using bone crusher, and disinfect and treated using (NaOH) and (Na CL). The graft particles are immediately placed into the fresh extraction socket and sutured. Twenty Yemeni patients requiring impacted lower third molar and upper canine teeth surgical extractions will be included. The healing process will be evaluated both clinically and radiographically over a 6-month period. Cone-beam computed tomography (CBCT) scans will be used to assess bone density and alveolar ridge dimensions before extraction and at six months' post-intervention. The study aims to determine whether autogenous tooth bone grafts can effectively reduce post-extraction alveolar bone resorption and maintain ridge dimensions, supporting their potential use as an autologous, biocompatible, and economically feasible graft material for clinical socket preservation.

• Study Type: Interventional
• Enrollment (Actual): 20
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Yemen
  • Sanaa Governorate
    • Sanaa, Sanaa Governorate, Yemen
      • Sana'a University faculty of Dentisrty

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• - Absence of systemic diseases.
• Very good to accepted oral hygiene.
• Patients with impacted teeth requiring extraction.
• Patients between the ages of 16 and 50.
• No history of smoking.
• No history of any other drug use.
• Patients who were cooperative, motivated, to attend the follow-up and maintenance visits.

Exclusion Criteria:

• Systemic conditions or pharmacological therapies that could be an absolute contraindication for the intervention (such as un controlled diabetics, immunocompromised states, or treatment with oral or parenteral bisphosphonates).
• Poor oral hygiene.
• Acute exacerbation of chronic infection like pain or swelling.
• Pregnant women, children, elderly (>60 years), physically and mentally challenged, terminally and seriously ill.
• Hight Smoking tendency.
• Patients who refused to participate in the trial.
• Uncooperative Patients who won't be able to maintain the follow up visits

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

Experimental: Autogenous Tooth Bone Graft Intervention Group; "In this arm of the study, participants will receive an autogenous tooth bone graft for alveolar socket preservation following surgical tooth extraction. The intervention involves the extraction of the patient's own tooth, which will be processed and used as a bone graft. This graft will be placed into the empty socket immediately after the extraction. The purpose of this intervention is to prevent bone resorption, promote natural healing, and support bone regeneration within the extraction site. CBCT scans will be performed before extraction to measure baseline bone dimensions and will be repeated 6 months post-intervention to assess the success of bone preservation in terms of height, width, and density."

Biological: "Autogenous Tooth Bone Graft"; "The intervention involves the use of the patient's own extracted tooth to create a bone graft for alveolar socket preservation following surgical tooth extraction. The patient's tooth is carefully processed to remove caries, periodontal ligaments, pulp, and any restorative materials, leaving behind a complete tooth structure (enamel, dentin, and cementum). This tooth is then crushed, disinfected, and treated before being placed into the empty socket. This graft helps maintain the structure of the alveolar bone by promoting natural bone regeneration and preventing resorption. The bone graft will be monitored for its efficacy in preserving alveolar bone height, width, and density, assessed using Cone Beam Computed Tomography (CBCT)."

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
"Alveolar Bone Height, Width, and Density Preservation with Autogenous Tooth Bone Graft"	This study aims to evaluate the effectiveness of autogenous tooth bone grafts in preserving alveolar bone following tooth extraction. The study will assess changes in alveolar bone height, width, and density using Cone Beam Computed Tomography (CBCT) at two time points: before extraction (baseline) and 6 months post-grafting. The outcome measures are: Alveolar Bone Height: Measured in millimeters using CBCT at baseline and 6 months. Alveolar Bone Width: Measured in millimeters using CBCT at baseline and 6 months. Alveolar Bone Density: Measured in Hounsfield units using CBCT at both time points. The intervention involves using the patient's own extracted tooth to create a bone graft placed into the socket, promoting healing and bone regeneration. This study will determine the effectiveness of autogenous tooth bone grafts in preventing bone resorption and preserving alveolar socket structure.	"Before extraction and 6 months post-intervention"

Collaborators and Investigators

• Sponsor: Haifaa Mohammed Al-hussini
• Investigators: Principal Investigator: Haifaa Alhussini, BDS, MSc, Sana'a University Faculty of Dentistry

Publications and helpful links

General Publications

• Valdec S, Pasic P, Soltermann A, Thoma D, Stadlinger B, Rucker M. Alveolar ridge preservation with autologous particulated dentin-a case series. Int J Implant Dent. 2017 Dec;3(1):12. doi: 10.1186/s40729-017-0071-9. Epub 2017 Mar 30.
• Mahardawi B, Damrongsirirat N, Dhanesuan K, Subbalekha K, Mattheos N, Pimkhaokham A. Radiographic changes after alveolar ridge preservation using autogenous raw tooth particles versus xenograft: A prospective controlled clinical trial. Clin Oral Implants Res. 2024 Dec;35(12):1597-1606. doi: 10.1111/clr.14348. Epub 2024 Aug 12.

Helpful Links

• This study compares the effectiveness of autogenous raw tooth particles versus xenografts in preserving alveolar bone after tooth extraction. It uses radiographic assessments to evaluate bone resorption and preservation over time. The research provides i
• "This study discusses the use of autologous particulated dentin as a bone substitute for alveolar ridge preservation. The method demonstrates the potential of autologous dentin for bone augmentation in implant therapy, providing a viable alternative to x

Study record dates

Study Major Dates

• Study Start (Actual): July 14, 2024
• Primary Completion (Actual): November 1, 2025
• Study Completion (Estimated): August 31, 2026

Study Registration Dates

• First Submitted: November 23, 2025
• First Submitted That Met QC Criteria: December 4, 2025
• First Posted (Actual): December 5, 2025

Study Record Updates

• Last Update Posted (Actual): December 5, 2025
• Last Update Submitted That Met QC Criteria: December 4, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Keywords: Socket Preservation; Autogenous Tooth Bone Graft; CBCT Imaging; Bone Density Measurement; Bone Regeneration in Dentistry
• Other Study ID Numbers: SU-DENT-ATBG-2025-HH

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: "We will share anonymized individual participant data (IPD), including baseline characteristics, clinical assessments, and key outcome measures (alveolar bone height, width, and density) collected before and after the autogenous tooth bone graft intervention. Access to the data will be granted to qualified researchers who meet the criteria for data sharing and comply with the applicable data use agreement."
• IPD Sharing Time Frame: "IPD and supporting information will be made available starting 12 months after the completion of the study. The data will be accessible for a period of 5 years."
• IPD Sharing Access Criteria: "Access to IPD and supporting information will be granted to qualified researchers who submit a data request via the ClinicalTrials.gov platform. Researchers must meet the criteria outlined in the Data Use Agreement, which ensures that the data will be used responsibly and for research purposes only."
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL; SAP; ICF

Study Data/Documents

1. Clinical Study Report
   Information identifier: https://doi.org/10.1111/clr.14
   Information comments: This data includes radiographic changes from the clinical trial involving alveolar ridge preservation using autogenous tooth particles and xenograft materials.
2. Clinical Study Report
   Information identifier: https://doi.org/10.1186/s40729
   Information comments: "This study explores the use of autologous particulated dentin as a novel approach for alveolar ridge preservation. The intervention involves the patient's own extracted tooth, which is processed into dentin particles and used as a bone graft material. The study demonstrates successful outcomes in terms of bone regeneration and subsequent implant placement, suggesting that autologous dentin may be a promising alternative to traditional grafting materials.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No