Evaluation of Occlusal Adjustment Material Removal on Monolithic Zirconia Blocks: An In Vitro Study

This study aims to improve understanding of the amount of tooth-replacement material removed during a single grinding "stroke" performed in the adjustment of a zirconia crown. Zirconia is a highly durable ceramic material commonly used for dental restorations, and accurate adjustment is essential for achieving proper occlusion. However, existing literature does not provide quantitative data regarding material removal per stroke during chairside adjustment, resulting in reliance on individual clinical experience.

In this study, standardized zirconia specimens will be prepared and assigned to three operator groups: dental students, dental interns, and experienced clinicians. Each participant will perform a controlled number of grinding strokes on the specimens using a commonly used dental grinding stone. Specimens will be scanned before and after grinding using a three-dimensional scanner to precisely quantify material removal.

Hypothesis

The hypotheses of this study are:

Each grinding stroke results in a measurable and relatively consistent amount of zirconia material removal.

Experienced clinicians demonstrate more controlled and predictable material removal per stroke compared with students and interns.

Study Overview

• Status: Not yet recruiting
• Conditions: Dental Occlusion; Occlusal Wear of Teeth; Fixed Dental Prosthesis
• Intervention / Treatment: Procedure: perform material removal on monolithic zirconia

Detailed Description

Clinical occlusal adjustment requires precision within tens of micrometers; however, current literature lacks objective data regarding per-stroke material removal during chairside adjustment of monolithic zirconia. As a result, clinical decision-making largely depends on subjective judgment.

Objective

The objective of this study is to quantify material removal per single reciprocating grinding stroke on monolithic zirconia blocks using a silicon carbide grinding stone and to compare performance among operators with different levels of clinical experience.

Methods

Monolithic zirconia specimens (VITA YZ ST; dimensions: 8 × 2 × 15 mm) will be milled, sintered, and embedded into standardized holders. Operators will include 40 fourth-year dental students, 40 sixth-year dental interns, and 40 experienced clinicians. Each participant will perform 100 grinding strokes along an 8-mm linear path at a frequency of 100 strokes per minute, guided by a metronome.

Grinding will be performed using a silicon carbide stone (Dura-Green Stone HP 0031/PC2, SHOFU, Japan) operated at 20,000 rpm. Pre- and post-grinding scans will be obtained using a 3Shape F8 scanner. Scan datasets will be superimposed using feature-based alignment to calculate volumetric loss and thickness reduction, expressed as mm³ per stroke and µm per stroke, respectively.

Statistical Analysis

Mixed-effects models will be applied to evaluate group-by-stroke interactions. Reference intervals for material removal will be established, and results will be translated into a clinically applicable occlusal adjustment guide.

Expected Results

The study is expected to define the magnitude and variability of zirconia material removal per grinding stroke, identify differences in performance between operator experience levels, and highlight areas requiring targeted educational training.

Conclusion

This in vitro investigation will provide the first stroke-level quantitative evidence for monolithic zirconia occlusal adjustment. The findings are expected to enhance the accuracy of clinical decision-making, improve training assessment, and support evidence-based guidelines for zirconia crown adjustment.

• Study Type: Observational
• Enrollment (Estimated): 120

Contacts and Locations

• Study Contact: Name: Yihao Lan, DDS, MSD; Phone Number: 0922901103; Email: blue-mac@hotmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

The study population consists of 120 participants from three levels of dental training and early clinical practice, recruited from a dental school and affiliated clinical institutions. The sample includes:

1. Fourth-year dental students
2. Sixth-year dental interns
3. Clinicians with 0-5 years of post-graduation experience

Participants are generally healthy adults capable of performing fine motor tasks required for dental procedures. Exclusion criteria include acute hand/upper-limb injuries, neuromuscular disorders, uncorrected poor vision, and inability to follow a metronome rhythm.

Description

Inclusion Criteria:

Group A: Forty fourth-year dental students who have completed preclinical courses in operative dentistry, complete denture prosthodontics, and fixed prosthodontics (Part I). They have little to no experience in adjusting zirconia.

Group B: Forty sixth-year dental interns. Each participant will be tested twice-once before and once near the end of their clinical training. A questionnaire will also record their prosthodontic clinical experience within the past year.

Group C: Forty licensed clinicians with 0-5 years of post-graduation experience (with practical experience in zirconia adjustment). A questionnaire will also document their clinical experience in prosthodontics.

Exclusion Criteria:

• Acute upper-limb/hand injuries or postoperative recovery within the past 3 months that may affect grip strength or fine motor control.
• Neuromuscular disorders or tremor/postural control impairments (e.g., essential tremor, peripheral neuropathy, moderate to severe carpal tunnel syndrome) that prevent stable operation.
• Uncorrected or inadequately corrected vision that does not meet the requirements for close-range tasks (e.g., inability to clearly see fine markings at a distance of 30-40 cm even with correction).
• Inability to follow the metronome rhythm (100 beats per minute).

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
A.fourth-year dental students; Forty fourth-year dental students who have completed preclinical courses in operative dentistry, complete denture prosthodontics, and fixed prosthodontics (Part I). They have little to no experience in adjusting zirconia.	Procedure: perform material removal on monolithic zirconia; Each participant will perform 100 strokes along an 8-mm path at a rate of 100 strokes per minute, guided by a metronome on the monolithic zirconia
B.sixth-year interns; Forty sixth-year dental interns. Each participant will be tested twice-once before and once near the end of their clinical training. A questionnaire will also record their prosthodontic clinical experience within the past year.	Procedure: perform material removal on monolithic zirconia; Each participant will perform 100 strokes along an 8-mm path at a rate of 100 strokes per minute, guided by a metronome on the monolithic zirconia
C.clinicians; Forty licensed clinicians with 0-5 years of post-graduation experience (with practical experience in zirconia adjustment). A questionnaire will also document their clinical experience in prosthodontics.	Procedure: perform material removal on monolithic zirconia; Each participant will perform 100 strokes along an 8-mm path at a rate of 100 strokes per minute, guided by a metronome on the monolithic zirconia

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The amount of material removal per stroke	Amount of Zirconia Material Removed per Grinding Stroke(um/stroke); Mean thickness of material removed per stroke; Median thickness of material removed per stroke	about 12 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Material Removal Rate Between Grinding Phases	Difference in mean zirconia material removal per stroke between early grinding phase (strokes 1-50) and late grinding phase (strokes 51-100) Unit of Measure: μm/stroke (difference between phases)	approximately 12 months
Percentile Distribution of Zirconia Material Removal by Operator Experience Level	Percentile distribution (e.g., 25th, 50th, 75th percentiles) of zirconia material removal per grinding stroke within each operator experience group Unit of Measure: percentile values	approximately 12 months

Collaborators and Investigators

• Sponsor: National Taiwan University Hospital
• Investigators: Study Director: Yihao Lan, DDS, MSD, National Taiwan University Hospital

Study record dates

Study Major Dates

• Study Start (Estimated): February 1, 2026
• Primary Completion (Estimated): June 1, 2027
• Study Completion (Estimated): December 31, 2027

Study Registration Dates

• First Submitted: December 1, 2025
• First Submitted That Met QC Criteria: December 1, 2025
• First Posted (Estimated): December 12, 2025

Study Record Updates

• Last Update Posted (Actual): December 30, 2025
• Last Update Submitted That Met QC Criteria: December 23, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Keywords: Monolithic zirconia; occlusal adjustment; Material removal; Silicon carbide stone; 3D scan registration
• Additional Relevant MeSH Terms: Wounds and Injuries; Chemically-Induced Disorders; Poisoning; Bites and Stings
• Other Study ID Numbers: 202510051RINA

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: If other research teams conduct similar experiments, we may consider releasing the relevant study data in a de-identified format.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No