Comparison Between Platelet Rich Plasma and Nanofat as an Adjuvant Therapy in HairTransplantation

Comparison Between Platelet Rich Plasma and Nanofat as an Adjuvant Therapy in Hair Transplantation in Male Androgenic Alopecia

• To compare the efficacy of platlet rich plasma and Nanofat injection as adjuvant therapies with FUE hair transplantation in improving graft survival rate,
• To measure hair density and thickness postoperatively using dermoscopy or trichoscopy.
• To evaluate patient satisfaction and photographic assessment by blinded evaluators.
• To assess any adverse effects or complications related to each modality

Study Overview

• Status: Not yet recruiting
• Conditions: Androgenic Alopecia
• Intervention / Treatment: Procedure: hair transplantation

Detailed Description

• Ideal candidates for hair transplantation typically present with a clear, stable pattern of hair loss, characterized by at least 50% thinning or balding in 1 or more areas. The scalp must be healthy, with donor hair of good quality and quantity. Patients must have realistic expectations and be free of medical conditions that compromise surgical outcomes. The safe donor zone is located in the mid-occipital region between the upper and lower occipital protuberances, typically containing 65 to 85 follicular units/cm²
• Intra-operative injection of PRP is beneficial in giving faster density, reducing the catagen loss of transplanted hair, early recovery of the skin, the faster appearance of new anagen hair in FUE hair transplantation.
• This study compares the effects of PRP and Nano fat as adjuvants in Androgenic alopecia patients undergoing FUE hair transplantation.
• Nanofat contain stem cells supposed to improve the results of FUE hair transplantation , but the question that we hope to answer at the end of our study which one we recommend as an adjuvant therapy PRP or Nano fat?

• Study Type: Interventional
• Enrollment (Estimated): 30
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: shenouda Faiez, AL; Phone Number: 0201285122844; Email: shenoda011111@med.sohag.edu.eg
• Study Contact Backup: Name: mostafa haredy, MD; Phone Number: 0201095159392; Email: mostafaharedy84@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• 1. Male patients with stable androgenic alopecia more than 2 years. 2. Age 20-50 years 3. No recent medical hair loss treatments.

Exclusion Criteria:

• 1. Active scalp infections or scarring alopecia. 2. Systemic diseases affecting wound healing. 3. Platelet disorders or anticoagulant use. 4. Smoking or heavy alcohol intake

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: group a; hair transplantation done alone without platelet rich plasma or nanofat injection	Procedure: hair transplantation; we compare the effect of nanofat injection and platelet rich plasma in hair transplantation in male androgenic alopecia; Other Names: hair transplantation with platelet rich plasma; hair transplantation with nanofat injection
Experimental: group b; we do injection of platelet rich plasma with hair transplantation	Procedure: hair transplantation; we compare the effect of nanofat injection and platelet rich plasma in hair transplantation in male androgenic alopecia; Other Names: hair transplantation with platelet rich plasma; hair transplantation with nanofat injection
Experimental: group c; we do injection of nanofat with hair transplantation	Procedure: hair transplantation; we compare the effect of nanofat injection and platelet rich plasma in hair transplantation in male androgenic alopecia; Other Names: hair transplantation with platelet rich plasma; hair transplantation with nanofat injection

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
• To measure hair density using dermoscopy.	To measure how many hair follicles in each cubic centimetre	• All patients will be followed up about 6-12 months postoperative.

Collaborators and Investigators

• Sponsor: Sohag University
• Investigators: Study Chair: samia saied, MD, Sohag University

Publications and helpful links

General Publications

• Evin N, Guray Evin S. Camouflage of Postburn Scarring Alopecia Using Nanofat Grafting and Follicular Unit Hair Transplantation. Plast Reconstr Surg. 2024 Jul 1;154(1):207-215. doi: 10.1097/PRS.0000000000010759. Epub 2023 May 26.

Helpful Links

• Outcome of Intra-operative Injected Platelet-rich Plasma Therapy During Follicular Unit Extraction Hair Transplant: A Prospective Randomised Study in Forty Patients

Study record dates

Study Major Dates

• Study Start (Estimated): January 1, 2026
• Primary Completion (Estimated): June 1, 2027
• Study Completion (Estimated): December 1, 2027

Study Registration Dates

• First Submitted: November 22, 2025
• First Submitted That Met QC Criteria: December 3, 2025
• First Posted (Actual): December 17, 2025

Study Record Updates

• Last Update Posted (Actual): December 17, 2025
• Last Update Submitted That Met QC Criteria: December 3, 2025
• Last Verified: November 1, 2025

More Information

Terms related to this study

• Keywords: hair transplantation
• Additional Relevant MeSH Terms: Pathological Conditions, Anatomical; Skin Diseases; Hypotrichosis; Hair Diseases; Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Alopecia
• Other Study ID Numbers: Soh-Med--25-11-1MD

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No