- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06110377
MALE HAIR LOSS - Treatment With Dutasteride Mesotherapy x Dutasteride MMP Technique (Injections With Tattoo Machine) (MMP)
October 30, 2023 updated by: Clinica Dermatologica Arbache ltda
MALE ANDROGENETIC ALOPECIA - Treatment With Dutasteride Injections: Mesotherapy (Injections With Syringe and Needle) x MMP Technique (Microinjections With Tattoo Machine)
This randomized clinical trial carried out on 60 Brazilian men, aged 18 to 65, with mild or moderate androgenetic alopecia.
Two techniques for administering dutasteride will be compared, injected by syringes or needles or by needling through tattoo machines.
Study Overview
Status
Recruiting
Conditions
Study Type
Interventional
Enrollment (Estimated)
60
Phase
- Phase 4
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: SAMIR ARBACHE, PhD
- Phone Number: 12 981221011
- Email: samir.arbache@gmail.com
Study Locations
-
-
São Paulo
-
São José dos Campos, São Paulo, Brazil, 12245-760
- Recruiting
- Clinica Dermatologica Arbache
-
Contact:
- Samir Arbache, PhD
- Phone Number: +55 12 981221011
- Email: samir.arbache@gmail.com
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
- Healthy volunteers male patients.
- Aged 18 to 65 years.
- Patients with male androgenetic alopecia (grades III - V of the Norwood/Hamilton scale)
- Commitment not to initiate any other treatment, topical, systemic or intralesional, that interferes with hair growth during the study period.
- Patient without systemic treatment for AGA (5 reductase inhibitors) for more than 12 months or without topical treatment for more than 6 months before the start of the study.
- Allow the creation of two micro tattoos (maximum size of 1 mm each, resembling a hairy infundibulum) in the area that will be treated, in order to standardize the trichoscopic analysis.
- With the aim of photographic standardization, the patient must agree to have their hair cut in a standardized way in the first and last interventions.
- Patient about to get his partner pregnant.
- Patient must refrain from donating blood during the investigation and up to 6 months after the last intervention,
- Patient must abstain from drinking alcoholic beverages, abstain from using inhaled or injectable drugs, abstain from using illicit drugs within 30 days of entering the study,
- Patients without a psychiatric diagnosis and who behave appropriately during the interview,
- Signs of good hygiene and that have the ability to keep the areas undergoing treatment clean until they heal,
- Patients who understand and speak Portuguese,
- Patients with realistic expectations regarding the final benefits of treatment,
- Needle phobia,
- Independent patient, eliminating the need for tutoring or legal representative,
- Absence of chronic viral diseases, for example HIV, hepatitis B or hepatitis C,
- Absence of other skin diseases, for example lichen planus, psoriasis, Crohn's disease or ulcerative colitis,
- Absence of immunosuppression, for example: lymphoma, transplant therapy, chronic corticosteroid use, Wiskott-Aldrich Syndrome or uncontrolled malignancy,
- Patients/participants with previously known allergies or those detected during the interventions (anesthetics, topical antibiotics or other medications used in the trials),
- Absence of clinically significant cardiovascular disease (e.g. previous myocardial infarction), absence of coagulopathy or use of anticoagulants, absence of neurological disease (e.g. stroke, cerebral ischemia), absence of renal, hepatic or endocrine disease (e.g. example, diabetes).
- Patient/participant with medical conditions not mentioned, which in the investigator's view, prohibit participation in the study.
- Signature of informed consent
Exclusion Criteria:
- Detection during the test of allergy to the medicines used (anesthetics, topical antibiotics or other medicines used in the tests),
- Breach of protocol, inappropriate conduct that compromises participant safety or interferes with the interpretation of study results,
- Any illness or condition, which in the judgment of the investigators, interferes with the participant's ability to complete or terminate the investigation.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: MESOTHERAPY (INJECTIONS WITH SYRINGE AND NEEDLE)
After the anesthetic block, dutasteride will be injected using syringes and needles into the area of alopecia.
|
After the anesthetic block, dutasteride will be injected using syringes and needles into the area of alopecia.
|
Experimental: MMP (INJECTIONS WITH TATTOO MACHINE)
After the anesthetic block, dutasteride will be injected through needling performed by a tattoo machine in the area of alopecia.
|
After the anesthetic block, dutasteride will be injected through needling performed by a tattoo machine in the area of alopecia.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
HAIR DENSITY
Time Frame: 1 year
|
analysis of hair density (number of follicles) per square centimeter using Trichoscale software (fotofinder) and clinical photographs.
|
1 year
|
HAIR THICKNESS
Time Frame: 1 year
|
measurement of the thickness of hair shafts using Trichoscale software (fotofinder)
|
1 year
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Sexual effects
Time Frame: 1 year
|
Assessment of sexual adverse effects (sexual impotence or decreased libido) through Likert questionnaire: The answer will be dichotomous, did you feel any sexual effects (impotence or decreased libido during your treatment?
Yes or no?
|
1 year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Estimated)
October 30, 2023
Primary Completion (Estimated)
April 1, 2024
Study Completion (Estimated)
April 2, 2025
Study Registration Dates
First Submitted
October 22, 2023
First Submitted That Met QC Criteria
October 25, 2023
First Posted (Actual)
October 31, 2023
Study Record Updates
Last Update Posted (Actual)
November 1, 2023
Last Update Submitted That Met QC Criteria
October 30, 2023
Last Verified
October 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 004
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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