Antiplatelet Use in Dementia Subtypes

Antiplatelet Use in All-Cause Dementia and Dementia Subtypes Among Older Adults: A Population-Based Cohort Study

This population-based retrospective cohort study aimed to evaluate the appropriateness of antiplatelet therapy use among older adults with all-cause dementia and across different dementia subtypes. Medical records of patients aged 65 years and older who were evaluated at a tertiary-level geriatric outpatient clinic were reviewed. Dementia subtypes were classified according to internationally accepted diagnostic criteria. Patterns of antiplatelet use were assessed in accordance with current guideline recommendations. The study sought to determine the appropriateness of antiplatelet use across dementia subtypes and to describe real-world prescribing practices in this population.

Study Overview

• Status: Completed
• Conditions: Dementia; Dementia Disorder

• Study Type: Observational
• Enrollment (Actual): 683

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

The study population consists of older adults aged 65 years and older with a diagnosis of dementia who were evaluated in a tertiary-level geriatric outpatient clinic.

Description

Inclusion Criteria:

• Age 65 years and older.
• Diagnosis of dementia based on internationally accepted diagnostic criteria.
• Evaluation at a tertiary-level geriatric outpatient clinic.

Exclusion Criteria:

• Patients with incomplete or inaccessible medical records.
• Individuals with missing data on antiplatelet therapy use.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Dementia cohort; This cohort includes older adults aged 65 years and older diagnosed with dementia who were evaluated in a tertiary geriatric outpatient clinic. No intervention was assigned, as this is a retrospective observational study.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Appropriateness of antiplatelet therapy use	Assessment of the appropriateness of antiplatelet therapy use according to current guideline recommendations among older adults with dementia.	At baseline (first geriatric outpatient clinic visit)

Collaborators and Investigators

• Sponsor: Gulhane Training and Research Hospital

Study record dates

Study Major Dates

• Study Start (Actual): December 1, 2016
• Primary Completion (Actual): March 1, 2025
• Study Completion (Actual): March 1, 2025

Study Registration Dates

• First Submitted: December 17, 2025
• First Submitted That Met QC Criteria: December 17, 2025
• First Posted (Actual): December 31, 2025

Study Record Updates

• Last Update Posted (Actual): December 31, 2025
• Last Update Submitted That Met QC Criteria: December 17, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Keywords: Older adults; Antiplatelet therapy; Dementia subtypes
• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Mental Disorders; Neurocognitive Disorders; Tauopathies; Neurodegenerative Diseases; Alzheimer Disease; Dementia
• Other Study ID Numbers: GTRH-ANTIPL-DEM-01

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No