Relationship Between Serum Apolipoprotein Levels and Weight Loss in Patients Undergoing Sleeve Gastrectomy for Morbid Obesity

December 24, 2025 updated by: Yigit DUZKOYLU
The study looks at whether a specific protein in the blood, called apolipoprotein, can predict how much weight a person might lose after sleeve gastrectomy, a surgery for people with severe obesity. We want to find a specific level of this protein that shows which patients are most likely to lose weight successfully after surgery. By identifying this level, we hope to guide doctors in deciding who should have the surgery and who might do better with non-surgical weight loss methods.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Detailed Description

The subject of our research is whether serum apolipoprotein levels can be a predictive value for weight loss in patients who will undergo sleeve gastrectomy due to morbid obesity. Our aim is to determine a cut-off value for patients who benefit most from bariatric surgery based on preoperative serum apolipoprotein levels. By including this value among the surgical indications, we plan to direct patients less likely to benefit from surgery to conservative approaches.

Study Type

Observational

Enrollment (Estimated)

110

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey (Türkiye)
    • Basaksehir
      • Istanbul, Basaksehir, Turkey (Türkiye), 34480
        • Başakşehir Çam and Sakura City Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients applying to Başakşehir Çam Sakura City Hospital General Surgery Clinic for bariatric surgery

Description

Inclusion Criteria:

  • Patients aged 18 to 75
  • International Classification of Diseases (ICD) code E66 diagnosis (obesity)
  • Patients who have given consent for sleeve gastrectomy
  • Patients who are suitable for general anesthesia

Exclusion Criteria:

  • Patients who did not give consent to be included in the study
  • Patients who are scheduled for surgery other than sleeve gastrectomy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Sleeve Gastrectomy Patients
Patients who meet inclusion criteria for the study undergoing sleeve gastrectomy
Procedure: Laparoscopic Sleeve Gastrectomy
Laparoscopic Sleeve Gastrectomy

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Change in body mass index at 8 months
Time Frame: 8 months after surgery
8 months after surgery

Secondary Outcome Measures

Outcome Measure
Time Frame
Change in lipid profile at 8 months
Time Frame: 8 months after surgery
8 months after surgery

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Yigit DUZKOYLU

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 1, 2025

Primary Completion (Estimated)

June 1, 2026

Study Completion (Estimated)

June 1, 2026

Study Registration Dates

First Submitted

December 24, 2025

First Submitted That Met QC Criteria

December 24, 2025

First Posted (Actual)

January 8, 2026

Study Record Updates

Last Update Posted (Actual)

January 8, 2026

Last Update Submitted That Met QC Criteria

December 24, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2024-KAEK-11 134

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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