Rosemary Infusion for Hypertension With Hypertriglyceridemia

January 11, 2026 updated by: awatef Sassi

Rosemary Infusion for Hypertension With Hypertriglyceridemia: A Triglyceride-Stratified Clinical Study

This study aimed to evaluate the effects of daily rosemary infusion consumption on blood pressure and lipid profile in patients with mild hypertension, stratified by triglyceride status.

This 6-week open-label interventional study enrolled 47 patients with mild hypertension (systolic BP 140-159 mmHg and/or diastolic BP 90-99 mmHg). Participants were stratified into two groups: normal triglycerides, TG <1.7 mmol/L, n=22 and high triglycerides, TG ≥1.7 mmol/L, n=25. Blood pressure was assessed using 24-hour ambulatory monitoring (Holter) at baseline and day 45. Comprehensive biochemical analysis included lipid profile, hepatic and renal function markers, and inflammatory parameters.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

47

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Tunisia
      • Sousse, Tunisia, 4023
        • Sassi

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

Participants of both sexes, aged 18 years and older, were included in the study. The inclusion criteria were: (1) Presence of mild hypertension defined as systolic blood pressure (SBP) of 140-159 mmHg and/or diastolic blood pressure (DBP) of 90-99 mmHg according to the 2018 ESC/ESH guidelines(Williams et al., 2018); (2) No use of medications or dietary supplements for other health conditions.

Exclusion Criteria:

Participants were excluded if they had renal failure, autoimmune diseases, major gastrointestinal disorders, or a history of cardiovascular disease. Other exclusion criteria included current or past use of medications known or suspected to influence blood pressure or metabolic parameters

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Groupe triglycérides normaux TG < 1,7 mmol/L n = 22
Dietary supplement: Rosemary infusion
Rosemary infusion 100 ml during 45 days
Experimental: TG ≥ 1,7 mmol/L n = 25
Dietary supplement: rosemary infusion
Rosemary infusion 100 ml during 45 days

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Blood pressure measurement
Time Frame: 45 days
45 days
Evolution of serum triglycerides
Time Frame: 45 days
45 days

Secondary Outcome Measures

Outcome Measure
Time Frame
Cardiovascular disease risk assessment
Time Frame: 45 days
45 days
Atherogenic Index of Plasma
Time Frame: 45 days
45 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

awatef Sassi

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 1, 2024

Primary Completion (Actual)

April 1, 2025

Study Completion (Actual)

April 1, 2025

Study Registration Dates

First Submitted

January 11, 2026

First Submitted That Met QC Criteria

January 11, 2026

First Posted (Actual)

January 20, 2026

Study Record Updates

Last Update Posted (Actual)

January 20, 2026

Last Update Submitted That Met QC Criteria

January 11, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • TGhypertension

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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