The TOF3D Mechanomyograph. Evaluation of a New Device for Assessment of the Neuromuscular Block. (MMG versus AMG)

January 19, 2026 updated by: Klinikum Hersfeld-Rotenburg

In clinical anesthesiologic practice, most institutions use acceleromyography in order to assess the degree of a neuromuscular block.

The aim of the present study is to assess a new device using mechanomyography. Until recently, this method was reserved for experimental settings. It seems to be able to work more precisely, and additionally, it offers the opportunity to use other stimulation patterns than acceleromyographic measurements.

The investigation is divided into two parts:

Part 1 compares the mechanomyograph directly with an acceleromyograph. In part 2, two mechanomyographs using different stimulation patterns are compared with each other.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

50

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Germany
      • Bad Hersfeld, Germany, 36251
        • Recruiting
        • Department of Anesthesia and Intensive Care Medicine
        • Contact:
        • Principal Investigator:
          • Stefan Soltesz, Professor

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • patients scheduled for surgery requiring general anesthesia with neuromuscular blocking agents

Exclusion Criteria:

  • anticipated or known difficult airway
  • increased risk for aspiration
  • pregnancy
  • neuromuscular disorders

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Diagnostic
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: comparison of mechanomyograph and acceleromyograph
Device: measurement of the time course of a neuromuscular block
a new device is compared to an established one.
Other: comparison of tetanic fade versus train of four ratio
Device: measurement of the time course of a neuromuscular block
a new device is compared to an established one.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
difference in time to recovery to a train of four ratio of 1,0.
Time Frame: from enrollment to the end of anesthesiologic treatment at the day of surgery (2-3 weeks after enrollment)
difference in time to recovery to a train of four ratio of 1,0 measured by acceleromyography and mechanomyography, respectively
from enrollment to the end of anesthesiologic treatment at the day of surgery (2-3 weeks after enrollment)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Klinikum Hersfeld-Rotenburg

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 9, 2026

Primary Completion (Estimated)

December 1, 2026

Study Completion (Estimated)

July 1, 2027

Study Registration Dates

First Submitted

January 10, 2026

First Submitted That Met QC Criteria

January 19, 2026

First Posted (Actual)

January 27, 2026

Study Record Updates

Last Update Posted (Actual)

January 27, 2026

Last Update Submitted That Met QC Criteria

January 19, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • MMG and TOF3D

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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