Effects of Patients' Hormone Levels on Sedoanalgesia

Observation of the Effect of Patients' Hormone Levels on Sedoanalgesia in Oocyte Pcik-Up: Prospective Observational Study

Investigastors hypothesis is that the need for anaesthetic agents is less in patients with high progesterone levels and more in patients with high estrogen levels.

Study Overview

• Status: Not yet recruiting
• Conditions: Sedoanalgesia; Consumption of Anaesthetic Agents
• Intervention / Treatment: Drug: Anesthesia Maintenance

Detailed Description

In anaesthesia practice, the need for anaesthetic agents can be affected by many different factors. These factors may include age, gender, body weight, existing hepatic or renal insufficiency, cardiovascular diseases, low ejection fraction, and some hormonal changes may also be effective in the need for anaesthetic agents. For example, there are studies showing that progesterone, which increases in the last period of pregnancy in pregnant women, decreases the use of anaesthetic agents due to its central effects. In a study by, the MAC level of sevoflurane was measured by following the haemodynamic data and bispectral indexes of the patients and the amount of sevoflurane used was found to be less in patients with higher serum progesterone levels in pregnant women with gestational pregnancies older than 36 weeks undergoing planned cesarean section.

Estrogen and progesterone ratios regulate gonadotropin secretion and sexual behaviour in the brain. In addition, although it is known to be effective in analgesia and pain sensation pathways, this mechanism has not yet been fully understood . In an experimental animal study, it was concluded that estrogen facilitates pain transmission in acute pain pathways. In an animal study conducted in female rats, the need for anaesthetic agent in anaesthesia practice can be affected by many different factors at different times of the menstrual cycle phases. These factors may include age, gender, body weight, existing hepatic or renal insufficiency, cardiovascular diseases, low ejection fraction, and some hormonal changes may also be effective in the need for anaesthetic agents. For example, there are studies showing that progesterone, which increases in the last period of pregnancy in pregnant women, decreases the use of anaesthetic agents due to its central effects. In a study, the MAC level of sevoflurane was measured by following the haemodynamic data and bispectral indexes of the patients and the amount of sevoflurane used was found to be less in patients with higher serum progesterone levels in pregnant women with gestational pregnancies older than 36 weeks undergoing planned cesarean section.

Estrogen and progesterone ratios regulate gonadotropin secretion and sexual behaviour in the brain. In addition, although it is known to be effective in analgesia and pain sensation pathways, this mechanism has not yet been fully understood. In an experimental animal study, it was concluded that estrogen facilitates pain transmission in acute pain pathways. In an animal study in female rats, it was concluded that the characteristics of mu receptors in the brain changed in relation with the amounts of estrogen and progesterone secretion at different times of menstrual cycle phases. There are many publications in the literature examining the effects of estrogen and progesterone on analgesia pathways.

In today's anaesthesia practice, we encounter a large number of female patients both in operation theatres and in daily anaesthesia. In the process of in vitro fertilisation treatments, which is one of these areas, the need for daily anaesthesia arises for many procedures. Especially oocyte collection is performed with sedational procedures. Before the oocyte collection procedure, various hormone supplements are administered to the patients to ensure oocyte maturation, and patients who are shown to have reached adequate hormone levels in the laboratory with pre-procedure USG examination are taken to the oocyte collection procedure for aspiration of the follicles formed. This procedure requires a level of sedation in which patients can be immobilised and painless.

Investigastors hypothesis is that the need for anaesthetic agents is less in patients with high progesterone levels and more in patients with high estrogen levels.

The investigators' plan in this study is to examine the correlations of progesterone level, estrogen level, progesterone/estrogen level parameters with anaesthetic agent consumption via 3 groups

• Study Type: Observational
• Enrollment (Estimated): 100

Contacts and Locations

• Study Contact: Name: GOZDE GURSOY CIRKINOGLU, MD; Phone Number: 00905544071757; Email: dr.gozde.gursoy@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Between 18-45 years old

• ASA-I ASA-II patients who were sedated for oocyte pick-up between 1 June 2025 and 1 September 2025 at Izmir City Hospital
• Patients whose hormone levels were measured in the preoperative period due to surgical indication and registered in the hospital data processing system

Description

Inclusion Criteria:

• Between 18-45 years old
• ASA-I ASA-II patients who were sedated for oocyte pick-up between 1 June 2025 and 1 September 2025 at Izmir City Hospital
• Patients whose hormone levels were measured in the preoperative period due to surgical indication and registered in the hospital data processing system

Exclusion Criteria:

• Lack of patient approvel
• Diagnosed psychiatric disorder
• Use of drugs affecting the central nervous system
• Presence of chronic pain syndrome
• History of continuous analgesic use due to chronic pain
• Hepatic and/or renal insufficiency
• BMI>30
• Changing the method of anaesthesia for any reason

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
OPU patients; patients progesteron estrogen levels and progesteron/estrogen ratios	Drug: Anesthesia Maintenance; the amount of propofol required to achieve depth of anaesthesia in mg/kg/minute

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Anesthetic consumptiom	the amount of propofol needed to provide adequate depth of anaesthesia in mg/kg/minute	intraoperative

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pulse oximeter	pulse oksimeter values at the begining, 10 minutes later and final	intraoperative
hearth rate changes	Heart rate (bp/min) at the begining, 10 minutes later, final	intraoperative
Blood pressure changes	Blood pressure values (mm/Hg) at the begining, 10 minutes later, final	intraoperative

Collaborators and Investigators

• Sponsor: Izmir City Hospital
• Investigators: Study Chair: Halide Hande Şahinkaya, MD, Izmir City Hospital, Anesthesiology and Reanimation Department; Study Chair: Tuba Kuvvet Yoldaş, MD, Izmir City Hospital, Anesthesiology and Reanimation Department; Study Chair: Zeki Tuncer Tekgul, Prof. Dr., Izmir City Hospital, Anesthesiology and Reanimation Department

Publications and helpful links

General Publications

• Lee J, Lee J, Ko S. The relationship between serum progesterone concentration and anesthetic and analgesic requirements: a prospective observational study of parturients undergoing cesarean delivery. Anesth Analg. 2014 Oct;119(4):901-905. doi: 10.1213/ANE.0000000000000366.

Study record dates

Study Major Dates

• Study Start (Estimated): January 30, 2026
• Primary Completion (Estimated): March 1, 2026
• Study Completion (Estimated): April 30, 2026

Study Registration Dates

• First Submitted: May 26, 2025
• First Submitted That Met QC Criteria: January 28, 2026
• First Posted (Actual): January 30, 2026

Study Record Updates

• Last Update Posted (Actual): January 30, 2026
• Last Update Submitted That Met QC Criteria: January 28, 2026
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Keywords: estrogen; Progesterone; sedoanalgesia; OPU
• Other Study ID Numbers: Oocyte Pick Up

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No