The Impact of 12 Week Retention of Nutrients on Skin and the Perception of Physical Health Status

This is a randomized, double-blind, placebo-controlled clinical trial exploring the effects of a 12-week dietary supplement regimen on skin condition and perceived overall health status.

The study will involve 120 healthy Chinese adults aged 18 and above with low daily fruit and vegetable intake. Participants will be randomly assigned to one of two groups: one group will take a combination of Nu Skin's Vitamin C & Green Tea Capsules and Multivitamin & Mineral Capsules, while the other group will take a matching placebo.

The primary goal is to assess if the supplement combination improves skin health after 12 weeks, measured through specialized facial imaging (assessing spots, redness, evenness) and probe measurements (assessing elasticity, moisture, gloss). Secondary goals include evaluating changes in participants' self-perceived health status (via quality of life, fatigue, and digestive health questionnaires), psychological resilience, memory, and exploring a new method for measuring skin carotenoid levels.

This study is not intended to verify the approved health functions of the products but to explore the potential combined effects of antioxidant and nutritional supplementation on skin and general well-being.

Study Overview

• Status: Recruiting
• Conditions: Healthy Volunteers; Health Status; Antioxidants; Skin Health; Dietary Supplementation
• Intervention / Treatment: Dietary supplement: Vitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules Combination; Dietary supplement: Placebo Combination (Matching)

• Study Type: Interventional
• Enrollment (Estimated): 120
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Yanwen Jiang; Phone Number: 13501700841; Email: jiangyanwen@china-norm.com

Study Locations

• China
  • Shanghai Municipality
    • Shanghai, Shanghai Municipality, China, 200072
      • Recruiting
      • Shanghai China-norm Quality Technical Service Co., Ltd.
      • Contact: Yanwen Jiang; Phone Number: 13501700841; Email: jiangyanwen@china-norm.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

1. Chinese adults of Asian descent aged 18 and above;
2. Daily fruit and vegetable intake < 240g (calculated based on the fruit and vegetable section of the food frequency questionnaire);
3. S3 measurement index < 30000;
4. Participants must possess basic Chinese reading comprehension and expression skills, and be able to independently complete questionnaire surveys;
5. Voluntary participation in the test and signing of the informed consent form;
6. Willingness to comply with all evaluation requirements.

Exclusion Criteria:

1. Presence of open facial skin lesions, clearly visible scars, acne marks, etc.;
2. Skin lesions, scars, or significant pigmentation on the hand measurement area;
3. Symptoms of skin disease on the face or hand measurement areas;
4. Having undergone medical aesthetic procedures within the last 6 months;
5. Participation in other clinical trials involving product use within the last 3 months;
6. Use of health supplements or nutritional supplements (e.g., vitamins, minerals) within the last 1 month;
7. Currently planning for pregnancy, pregnant, or lactating;
8. Presence of any disease under current treatment;
9. Any other health issues or chronic diseases that affect behavioral or cognitive abilities;
10. Other iatrogenic reasons identified by experts or professionals that may affect the evaluation results.

The S3 instrument refers to a Raman spectroscopy-based biophotonic scanner. The threshold for the S3 screening value is based on previously published literature, which indicated that participants with a daily fruit and vegetable intake of less than 240g had an average Raman spectroscopy biophotonic scanner score below 25,000. However, considering practical recruitment challenges, the inclusion criterion was set at < 30,000. The S3 device measures the Skin Carotenoid Index, a non-invasive biomarker reflecting skin carotenoid levels.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo Control Group	Dietary supplement: Placebo Combination (Matching); Participants take a matching placebo combination (identical in appearance and taste to the active supplements) orally twice daily
Experimental: Supplement Combination Group	Dietary supplement: Vitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules Combination; Participants take a combination of active supplements-specifically, Vitamin C & Green Tea Capsules and Multivitamin & Mineral Capsules-orally twice daily.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Facial Image Capture VISIA-7	Imaging sessions are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks)
Skin Elasticity Test Probe Cutometer	Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks)
Skin Gloss Measurement Glossmeter	Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Skin Moisture Content Corneometer	Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks)
Skin Hemoglobin Measurement Mexameter MX18 (Courage & Khazaka, Germany)	Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Skin Moisture Loss Meter Vapometer (Delfin, Finland)	Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Skin Carotenoid Index	Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Skin Condition Survey	This survey assesses participants' subjective perception of their skin condition over the past month. It consists of two parts: 1) The Fitzpatrick Skin Typing Questionnaire determines the participant's skin type (I-VI) based on genetic predisposition, tanning ability, and sun reaction. 2) The Skin Status Self-Assessment uses a 100mm visual analog scale for participants to rate various aspects of their skin, including photo-damage (acute and chronic), brightness, glossiness, smoothness, hydration, pore appearance, evenness, softness, elasticity, overall wrinkles, appearance, plumpness, firmness, and spots.	The scales and questionnaires are administered at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Physical Health and Life Status Survey	This comprehensive survey evaluates participants' perceived physical health and quality of life over the past month. It incorporates five validated instruments: the SF-36 Health Survey, the Frequency of Physical Discomfort Questionnaire, the Gastrointestinal Discomfort Symptoms Questionnaire , the Population-Based Visual Fatigue Scale, and the TCM Constitution Classification and Determination Self-Assessment Table .	The survey is administered at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Psychological State and Memory Level	This component measures participants' subjective psychological state and memory function over the past month. It uses two main instruments: 1) The Brief Resilience Scale (BRS) assesses the ability to bounce back from stress and adversity (psychological resilience). 2) The Multifactorial Memory Questionnaire (MMQ) is divided into three subscales evaluating memory satisfaction/ability (Contentment), frequency of memory failures (Ability), and the use of compensatory strategies (Strategy).	The assessment is conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Self-Evaluation Questionnaire	This questionnaire is specifically designed for participants to subjectively evaluate the effects of the product intervention. It assesses perceived improvements in areas such as energy levels, overall health status, immune function, recovery speed from illness, quality of life, and the product's contribution to long-term health using a Likert scale.	This questionnaire is administered only at follow-up visits: T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Height and Weight Measurement BMI	Body Mass Index (BMI) is calculated from height and weight measurements to assess weight status and changes over the intervention period.	Measurements are conducted at T0 (baseline, upon enrollment) and T12w (12 weeks).

Collaborators and Investigators

• Sponsor: ChinaNorm

Study record dates

Study Major Dates

• Study Start (Actual): November 3, 2025
• Primary Completion (Estimated): February 2, 2026
• Study Completion (Estimated): February 2, 2026

Study Registration Dates

• First Submitted: January 19, 2026
• First Submitted That Met QC Criteria: January 26, 2026
• First Posted (Actual): February 3, 2026

Study Record Updates

• Last Update Posted (Actual): February 3, 2026
• Last Update Submitted That Met QC Criteria: January 26, 2026
• Last Verified: January 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Organic Chemicals; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages; Carbohydrates; Sugar Acids; Acids, Acyclic; Carboxylic Acids; Hydroxy Acids; Inorganic Chemicals; Beverages; Plant Preparations; Biological Products; Complex Mixtures; Ascorbic Acid; Geritol; Tea; Minerals
• Other Study ID Numbers: W25002003

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No