Critical Care Admission Following Emergency Department's Resuscitation Room Care (SAUV-IRU)

SAUV IRU: A Multicenter Prospective Observational Study Describing Resuscitation Room Activity and Comparing Critical Care Admission After Direct vs Secondary Admission

This prospective multicenter observational study aims to describe resuscitation room activity in France and to compare critical care admission within 24 hours between patients directly admitted to the resuscitation room and those admitted secondarily after initial emergency department management. Adult patients admitted to the resuscitation room over a 72-hour period in participating centers will be included. Data collection includes patient characteristics, triage severity, physiological parameters, critical interventions, and outcomes at 24 hours.

Study Overview

• Status: Not yet recruiting
• Conditions: Shock; Critical Illness; Respiratory Failure; Resuscitation; Trauma (Including Fractures); Emergency Department Patient
• Intervention / Treatment: Other: Emergency resuscitation room management (observational)

Detailed Description

This is a prospective, multicenter, observational cohort study including all consecutive adult patients admitted to the resuscitation room in participating emergency departments over a predefined 72-hour study period. Patients are categorized according to their mode of admission to the resuscitation room (direct or secondary after initial emergency department management). No intervention is assigned by the study, and patient care follows usual practice and local protocols. Data collection includes patient-level clinical and physiological variables, resuscitation room processes of care, organizational characteristics at the center level, and practitioner-level characteristics. The primary outcome is critical care admission or death within 24 hours after resuscitation room admission.

Statistical analysis Analyses will be conducted in adult patients (≥18 years) admitted to the resuscitation room. Patients will be categorized according to the mode of resuscitation room admission (direct vs secondary).

The primary outcome is critical care admission or death within 24 hours after resuscitation room admission. The primary analysis will compare the proportion of patients meeting the primary outcome between groups using logistic regression, with adjustment for prespecified baseline variables and center effects. Results will be reported as odds ratios with 95% confidence intervals. Secondary and prespecified outcomes will be analyzed descriptively. Missing data will be described and analyses performed on available data.

An ancillary analysis will be conducted among patients who receive blood transfusion during resuscitation room management. This ancillary study will use the same prospective observational dataset and will not involve any additional data collection or modification of patient management. Analyses will focus on patient characteristics, indications for transfusion, transfusion practices, and short-term outcomes.

• Study Type: Observational
• Enrollment (Estimated): 1200

Contacts and Locations

• Study Contact: Name: Romain Genre Grandpierre, MD; Phone Number: +33674827514; Email: romain.genregrandpierre@chu-nimes.fr
• Study Contact Backup: Name: Fabien Coisy, MD, MSc; Email: fabien.coisy@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients (≥18 years old) admitted to the resuscitation room of participating emergency departments during the study period. All eligible patients admitted directly or secondarily to the resuscitation room are included consecutively, without intervention assignment. Patients are managed according to usual care and local protocols.

Description

Inclusion Criteria:

• Adult patients (≥18 years old) admitted to the resuscitation room during the study period.

Exclusion Criteria:

• Patients younger than 18 years.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Direct resuscitation room admission; Adult patients (≥18 years old) admitted directly to the resuscitation room from the prehospital setting or immediately upon arrival at the emergency department, without prior clinical management in another emergency department area.	Other: Emergency resuscitation room management (observational); Patients receive standard emergency care in the resuscitation room according to local protocols and clinician judgment. No intervention is assigned by the study. Clinical management, diagnostic procedures, and therapeutic interventions are recorded for observational purposes only.
Secondary resuscitation room admission; Adult patients (≥18 years old) admitted to the resuscitation room secondarily, after an initial evaluation or management in another emergency department area (e.g., standard treatment area, waiting area, imaging unit, or other hospital sector), before transfer to the resuscitation room.	Other: Emergency resuscitation room management (observational); Patients receive standard emergency care in the resuscitation room according to local protocols and clinician judgment. No intervention is assigned by the study. Clinical management, diagnostic procedures, and therapeutic interventions are recorded for observational purposes only.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Critical care admission within 24 hours after resuscitation room admission	Proportion of patients admitted to critical care (intensive care unit or intermediate care unit) or deceased within 24 hours following admission to the resuscitation room, comparing direct versus secondary resuscitation room admission.	Within 24 hours after resuscitation room admission

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
All-cause mortality within 24 hours	All-cause mortality occurring within 24 hours after resuscitation room admission.	Within 24 hours after resuscitation room admission
Use of critical care interventions in the resuscitation room	Proportion of patients receiving at least one critical care intervention in the resuscitation room, including airway management, mechanical ventilation or non-invasive ventilation, vasopressor therapy, transfusion, renal replacement therapy, or cardiopulmonary resuscitation.	Day 1
Center-level organizational characteristics	Description of resuscitation room organizational characteristics, including material resources, human resources, and availability of critical care equipment.	Baseline (during study period)
Physiological severity at resuscitation room admission-part 1	Blood pressure at admission	Baseline
Physiological severity at resuscitation room admission-part 2	Heart rate at admission	Baseline
Physiological severity at resuscitation room admission-part 3	Respiratory rate at admission	Baseline
Physiological severity at resuscitation room admission-part 4	Pulsed oxygen saturation at admission	Baseline
Physiological severity at resuscitation room admission-part 5	Temperature at admission	Baseline
Physiological severity at resuscitation room admission-part 6	Glasgow Coma Scale at admission	Baseline
Physiological severity at resuscitation room admission-part 7	Capillary blood glucose at admission	Baseline
Physiological severity at resuscitation room admission-part 8	Capillary blood glucose at admission	Baseline

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time from emergency department arrival to resuscitation room admission	Time interval between emergency department arrival and resuscitation room admission	Day 1
Blood transfusion during resuscitation room management	Proportion of patients receiving at least one blood product transfusion during resuscitation room management.	Day 1
Specialist consultation in the resuscitation room	Proportion of patients requiring at least one specialist consultation during resuscitation room management.	Day 1

Collaborators and Investigators

• Sponsor: Centre Hospitalier Universitaire de Nīmes
• Collaborators: Societe Française de Medecine d'urgence
• Investigators: Principal Investigator: Romain Genre Grandpierre, MD, Nimes University Hospital

Study record dates

Study Major Dates

• Study Start (Estimated): April 1, 2026
• Primary Completion (Estimated): April 1, 2026
• Study Completion (Estimated): April 1, 2026

Study Registration Dates

• First Submitted: January 26, 2026
• First Submitted That Met QC Criteria: February 9, 2026
• First Posted (Actual): February 17, 2026

Study Record Updates

• Last Update Posted (Actual): February 17, 2026
• Last Update Submitted That Met QC Criteria: February 9, 2026
• Last Verified: February 1, 2026

More Information

Terms related to this study

• Keywords: Emergency Department; Resuscitation Room; Critical Care Admission
• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Respiratory Tract Diseases; Respiration Disorders; Pathological Conditions, Signs and Symptoms; Respiratory Insufficiency; Emergencies; Critical Illness; Wounds and Injuries; Shock
• Other Study ID Numbers: IRB CHU Nîmes 25.11.01

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Individual participant data will not be shared because this observational study does not include a data sharing plan and data use is restricted to the objectives defined in the protocol.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No