Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages

Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages: A Three-Arm Randomized Controlled Trial

The study is meant to run parallel to the larger study, RESET. The goal of this study is to to evaluate the effectiveness of a once-off general and personality-tailored text message on GP consultation among RESET participants identified to have high LDL-C. The main question it aims to answer is:

Will participants exposed to personality tailored advice have a higher adherence to GP consultation compared to the participants in the control group?

Researchers will compare a personalized message to a general message (with no personalization according to patients personality type) and control group to see if the messages increase adherence.

Participants are required to complete two questionnaires: one before and one after they receive their RESET results.

Study Overview

• Status: Recruiting
• Conditions: Adherence; Preventive Health Services
• Intervention / Treatment: Behavioral: Personalized Message; Behavioral: General Message

• Study Type: Interventional
• Enrollment (Estimated): 3000
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Jocelyn Chew; Phone Number: +6565168687; Email: dbi-lab@nus.edu.sg

Study Locations

• Singapore
  • Singapore, Singapore, 117599
    • Recruiting
    • National University of Singapore

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• New participants of RESET who have given consent to be contacted for future studies
• ≥21 years old

Exclusion Criteria:

• are not able to read, write or communicate in English

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
No Intervention: Control
Experimental: Personality-Tailored Message	Behavioral: Personalized Message; The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered. The message will include the personality-tailored message with the same core content as the general message, including indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. An infographic will be included in the same ROR email. This message will contain an added component framed according to conscientiousness and neuroticism scores, as these traits are strong predictors of health behaviours. Scores will be derived from baseline BFI-44 results.
Active Comparator: General Message	Behavioral: General Message; The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered. The general health message will include indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. The infographic will be included in the same ROR email.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Intention to adopt a healthier diet	A 3-item, 7-point Likert scale assessing participants' intention to adopt a healthier diet. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to adopt a healthier diet.	From enrollment to 3 months after results have been returned.
Intention to engage in Physical Activity	A 3-item, 7-point Likert scale assessing participants' intention to engage in physical activity. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to engage in physical activity.	From enrollment to 3 months after results have been returned.
Intention to visit a General Practitioner	A 3-item, 7-point Likert scale assessing participants' intention to visit a general practitioner. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to visit a general practitioner.	3 months after results have been returned.

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Big Five Inventory - 44	A 44-item, 5-point Likert scale questionnaire that assesses the "Big Five" personality traits of a participant: namely Openness, Conscientiousness, Extraversion, Agreeableness, and Neuroticism, each represented as sub-scales. Subscale scores are calculated by summing the relevant items. The minimum / maximum score for each sub-scale is as follows, with higher scores indicating higher representation of the respective personality trait. Openness: 10/50 Conscientiousness: 9/45 Extraversion: 8/40 Agreeableness: 9/45 Neuroticism: 8/40	From enrollment

Collaborators and Investigators

• Sponsor: National University Health System, Singapore

Study record dates

Study Major Dates

• Study Start (Actual): November 25, 2025
• Primary Completion (Estimated): January 1, 2028
• Study Completion (Estimated): November 1, 2028

Study Registration Dates

• First Submitted: February 11, 2026
• First Submitted That Met QC Criteria: February 11, 2026
• First Posted (Actual): February 17, 2026

Study Record Updates

• Last Update Posted (Actual): April 13, 2026
• Last Update Submitted That Met QC Criteria: April 7, 2026
• Last Verified: April 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: NUS-IRB-2025-334

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No