The Role of Incorporating Acacia Gum in Foods on Glucose Homeostasis in Healthy Humans (AcaciaGlu)

The Role of Incorporating Acacia Gum in Foods on Glucose Homeostasis in Healthy Humans: a Pilot Study

Abnormal postprandial blood glucose (PPG) is considered as a strong predictor for developing metabolic diseases worldwide. Nowadays, little understanding is available on how a carbohydrate-rich food matrix and the starch structures within interact with the gastrointestinal tract to help in controlling PPG. In this investigation, the use Acacia gum enriched flour will be used to explore the effect of adding the gum as food supplement on PPG in healthy humans.

Study Overview

• Status: Completed
• Conditions: Health Adult Subjects
• Intervention / Treatment: Dietary supplement: incorporating acacia gum flour into commonly consume foods

• Study Type: Interventional
• Enrollment (Actual): 14
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Saudi Arabia
  • Jeddah, Saudi Arabia
    • King Fahd Medical Research center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Male and female self-reported healthy volunteers (aged 18 to 40 years)
• Normal to overweight individuals (body mass index (BMI) 18.5-30 kg/m2) o BMI is equal to body weight (kg) divided by height squared (m2)

Exclusion Criteria:

• History of substance abuse
• Excessive alcohol intake
• Pregnancy
• Diabetes
• Cardiovascular disease
• Cancer
• Any gastrointestinal disease e.g. irritable bowel syndrome or inflammatory bowel disease
• Kidney disease
• Liver disease
• Pancreatitis
• Use of medications likely to interfere with energy metabolism, appetite regulation and hormonal balance, including: anti-inflammatory drugs or steroids, antibiotics, androgens, phenytoin, erythromycin or thyroid hormones.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Acacia gum incorporated biscuits	Dietary supplement: incorporating acacia gum flour into commonly consume foods; incorporating acacia gum flour into commonly consume foods
No Intervention: control biscuits

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
postprandial blood glucose	0 minutes and postprandial timepoints: 15 minutes, 30 minutes, 60 minutes,120 minutes,180 minutes

Collaborators and Investigators

• Sponsor: King Abdulaziz University

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2023
• Primary Completion (Actual): August 30, 2023
• Study Completion (Actual): September 30, 2023

Study Registration Dates

• First Submitted: January 30, 2026
• First Submitted That Met QC Criteria: February 10, 2026
• First Posted (Actual): February 18, 2026

Study Record Updates

• Last Update Posted (Actual): February 18, 2026
• Last Update Submitted That Met QC Criteria: February 10, 2026
• Last Verified: February 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: 286-22; 596-290-1443 (Other Grant/Funding Number: The Deanship of Scientific Research (DSR) at King Abdulaziz University (KAU), Jeddah, Saudi Arabia)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No