A Phase I/II Study of ABSK141 in Patients With Advanced Solid Tumors ( ABSK141-101 )

A Phase I/II, Open-Label Study of ABSK141 to Assess Safety, Tolerability, Efficacy and Pharmacokinetics in Patients With KRAS G12D Mutant Advanced Solid Tumors

This is a first-in-human (FIH), exploratory, multicenter, open-label, phase I/II study of ABSK141 in patients with advanced solid tumors to to evaluate safety, tolerability, PK and optimize the dosage.

Study Overview

• Status: Recruiting
• Conditions: Solid Tumors, Adult
• Intervention / Treatment: Drug: ABSK141-400mg; Drug: ABSK141-Recommended Dose for Expansion (RDE); Drug: ABSK141-800mg; Drug: ABSK141-1200mg; Drug: ABSK141-Recommended Phase 2 dose (RP2D)

Detailed Description

The study will start with a dose escalation of oral ABSK141 in patients with advanced solid tumors harboring KRAS G12D mutation to evaluate safety, tolerability, and PK. The expansion part will investigate oral ABSK141 at the recommended doses for expansion (RDEs) to evaluate safety and efficacy among selected tumor types harboring KRAS G12D mutation and optimize the dosage.

The phase II study will further investigate oral ABSK141 at the recommended phase 2 doses (RP2Ds) to evaluate safety and efficacy among selected tumor types harboring KRAS G12D mutation.

• Study Type: Interventional
• Enrollment (Estimated): 401
• Phase: Phase 2; Phase 1

Contacts and Locations

• Study Contact: Name: Yu Zhang, Bachelor; Phone Number: +86-021-68912098; Email: yuco.zhang@abbisko.com

Study Locations

• China
  • Shanghai, China, 201321
    • Recruiting
    • Fudan University Shanghai Cancer Center
    • Contact: xianjun Yu, doctor

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

1. Patients should understand, sign, and date the written informed consent form prior to screening
2. Male or female age 18 years or older
3. Patients with histologically confirmed locally-advanced or metastatic solid tumors .

For backfill cohorts in the escalation part:

1. Patients must have the following solid tumor harboring KRAS G12D mutation:

   1. Colorectal cancer (CRC);
   2. Non-small cell lung cancer (NSCLC);
   3. Pancreatic ductal adenocarcinoma (PDAC);
2. Patients must have at least one measurable target lesion according to RECIST 1.1

For expansion Part:

1. Patients must have the following solid tumor harboring KRAS G12D mutation:

   1. Colorectal cancer (CRC);
   2. Non-small cell lung cancer (NSCLC);
   3. Pancreatic ductal adenocarcinoma (PDAC);
   4. Other solid tumors;
2. Patients must have at least one measurable target lesion according to RECIST 1.1

For phase II:

1. Patients with locally advanced or metastatic solid tumors confirmed by histological examination, whose disease has progressed after standard treatment or who are intolerant to standard treatment, or for whom there is currently no standard treatment.

2. Patients must have the following solid tumor harboring KRAS G12D mutation:

   1. Colorectal cancer (CRC);
   2. Non-small cell lung cancer (NSCLC);
   3. Pancreatic ductal adenocarcinoma (PDAC);
   4. Other solid tumors;
3. Patients must have at least one measurable target lesion according to RECIST 1.1 4. ECOG performance status 0 or 1 5. Adequate organ function and bone marrow function as indicated by the following screening assessments performed within 14 days prior to the first dose of study drug 6. For patients participating exploration of food effect:

(1) be able to eat a standardized high-fat, high caloric meal within 30 minutes (2) be able to fast for 10 hours

Exclusion Criteria:

1. Known allergy or hypersensitivity to any component of the investigational product
2. (For backfill cohorts and expansion part) Patients who were previously treated with an investigational KRAS G12D inhibitor, pan- or multi-RAS inhibitor, or had prior therapy with any direct RAS-targeted therapy
3. Has a known additional malignancy that is progressing or has required active treatment
4. Unable to swallow capsules or tablets or malabsorption syndrome, disease significantly affecting GI function, or resection of the stomach or small bowel, symptomatic inflammatory bowel disease or ulcerative colitis, or partial or complete bowel obstruction. If any of these conditions exist, the site should discuss with the sponsor to determine patient eligibility
5. Previous anti-tumor therapy, including chemotherapy, endocrine therapy, molecular targeted therapy or other investigational drugs received ≤2 weeks or ≤5-half life (whichever is shorter), radiotherapy and antibody therapy received ≤4 weeks prior to initiation of study treatment
6. Major surgery within 4 weeks of the first dose of study drug. Note that all surgical wounds must be healed and free of infection or dehiscence
7. Prior toxicities from chemotherapy, radiotherapy, and other anti-cancer therapies, including immunotherapy, that have not regressed to Grade ≤1 severity (CTCAE v5.0)
8. Patients should not use proton pump inhibitors for at least 7 days prior to the first dose of ABSK141 and during treatment with ABSK141.
9. P-gp inhibitor and strong CYP3A inhibitors to 7 days or 5 half-lives whichever is longer and for CYP3A inducers to 2 weeks or 5 half-lives
10. Active central nervous system (CNS) metastases
11. History of interstitial lung disease requiring systemic steroid treatment.
12. Impaired cardiac function or clinically significant cardiac disease
13. NSCLC cohorts: Patient previously identified as having a driver mutation (according to local standard of care or guidelines) and have not received any targeted therapy, for example: EGFR mutation, ALK rearrangement, KRAS G12C mutation, NTRK1/2/3 gene fusion, RET fusion, MET exon14 skipping mutation, BRAF V600E mutation, ROS1 rearrangement, etc
14. Known acquired immunodeficiency syndrome (AIDS)-related illness, or positive test for HIV 1/2 antibody
15. Exclusion of hepatitis infection
16. Patients with refractory/uncontrolled ascites or pleural effusion
17. Pregnant or nursing (lactating) women
18. refuse to use highly effective methods of birth control during the study and for up to 6 months after the last dose of study drug.
19. Sexually active males who refuse to use a condom during intercourse while taking drug and for 5 consecutive compound half-lives plus 60 days after stopping study drug.
20. Vaccination with a live, attenuated vaccine within 4 weeks prior to the first dose of study treatment except for administration of inactivate vaccines
21. Planned major surgery during study treatment
22. Any other clinically significant comorbidities

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Non-Randomized
• Interventional Model: Sequential Assignment
• Masking: None (Open Label)

Number of Arms

6

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Escalation part-400mg; ABSK141 (investigational drug) tablet, 400 mg administered orally once daily (QD), continuously until disease progression.	Drug: ABSK141-400mg; In the escalation part#patients will first orally receive a single dose of ABSK141 on D-3, followed by a three-day run-in period to assess the PK profile of singledose ABSK141 400mg administration. Thereafter, patients will continuously receive ABSK141 400mg once daily (QD).; Other Names: ABSK141, investigational drug
Experimental: expansion part; ABSK141 (investigational drug) tablet,Recommended Dose for Expansion (RDE) administered orally once daily (QD), continuously until disease progression.	Drug: ABSK141-Recommended Dose for Expansion (RDE); In the expansion part# patients will orally receive ABSK141 at the recommended dose for expansion (RDE).patients will continuously receive ABSK141 Recommended Dose for Expansion (RDE) once daily (QD).; Other Names: ABSK141, investigational drug
Experimental: Escalation part-800mg; ABSK141 (investigational drug) tablet, 800 mg administered orally once daily (QD), continuously until disease progression.	Drug: ABSK141-800mg; In the escalation part#patients will first orally receive a single dose of ABSK141 on D-3, followed by a three-day run-in period to assess the PK profile of singledose ABSK141 800mg administration. Thereafter, patients will continuously receive ABSK141 800mg once daily (QD).; Other Names: ABSK141, investigational drug
Experimental: Escalation part-1200mg; ABSK141 (investigational drug) tablet, 1200 mg administered orally once daily (QD), continuously until disease progression.	Drug: ABSK141-1200mg; In the escalation part#patients will first orally receive a single dose of ABSK141 on D-3, followed by a three-day run-in period to assess the PK profile of singledose ABSK141 1200mg administration. Thereafter, patients will continuously receive ABSK141 1200mg once daily (QD).; Other Names: ABSK141, investigational drug
Experimental: Backfill cohorts; ABSK141 (investigational drug) tablet, The decision-making on doses for backfill cohorts will be based on the discussion and alignment between the Sponsor and Investigator.	Drug: ABSK141-Recommended Dose for Expansion (RDE); In the expansion part# patients will orally receive ABSK141 at the recommended dose for expansion (RDE).patients will continuously receive ABSK141 Recommended Dose for Expansion (RDE) once daily (QD).; Other Names: ABSK141, investigational drug
Experimental: Phase II; ABSK141 (investigational drug) tablet, administered at the Recommended Phase 2 Dose (RP2D) continuously until disease progression.	Drug: ABSK141-Recommended Phase 2 dose (RP2D); Phase II #patients will orally receive ABSK141 at the Recommended Phase 2 Dose (RP2D).; Other Names: ABSK141, investigational drug

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence of DLTs	dose-limiting toxicities	from Run-in to Day28
Incidence and severity of AEs	Adverse events	from the time that the patient provides informed consent through and including 30 days after the last administration of ABSK141.
Incidence and severity of SAEs	serious adverse events	from the time that the patient provides informed consent through and including 30 days after the last administration of ABSK141.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cmax	maximum observed concentration	From pre-dose to up to 72 hours post-dose
AUC	area under the concentration-time curve	From pre-dose to up to 72 hours post-dose
t1/2	elimination half-life	From pre-dose to up to 72 hours post-dose
CL/F	apparent oral clearance	From pre-dose to up to 72 hours post-dose
tmax	time to maximum observed concentration	From pre-dose to up to 72 hours post-dose
ORR	Objective response rate	From the first dose date to the date of first confirmed response (CR/PR), assessed up to 24 months.
DOR	Duration of response	From date of first confirmed response (CR/PR) to date of first documented progression (PD) or death from any cause, whichever comes first, assessed up to 24 months.
PFS	Progression-free survival	From the first dose date to the date of first documented progressive disease (PD) or death from any cause, whichever occurs first, assessed up to 24 months.
DCR	Disease control rate	From the first dose date to the date of first documented disease status assessment (CR/PR/SD/PD), assessed up to 24 months.
OS	Overall survival	From the first dose date to the date of death from any cause, assessed up to24 months

Collaborators and Investigators

• Sponsor: Abbisko Therapeutics Co, Ltd
• Investigators: Principal Investigator: Xianjun Yu, Doctor, Fudan University

Study record dates

Study Major Dates

• Study Start (Actual): March 2, 2026
• Primary Completion (Estimated): December 30, 2028
• Study Completion (Estimated): July 30, 2029

Study Registration Dates

• First Submitted: January 28, 2026
• First Submitted That Met QC Criteria: February 10, 2026
• First Posted (Actual): February 18, 2026

Study Record Updates

• Last Update Posted (Actual): March 11, 2026
• Last Update Submitted That Met QC Criteria: March 9, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Keywords: KRAS G12D; ABSK141
• Additional Relevant MeSH Terms: Pharmaceutical Preparations; Drugs, Investigational
• Other Study ID Numbers: ABSK141-101

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No