Vision Therapy Outcomes in Amblyopia: Linking Brain Plasticity With Visual Perceptual Skills

March 7, 2026 updated by: Hatice Semrin Timlioglu İper, Okan University

Correlation of Vision Therapy With Visual-Cognitive Skills and Therapeutic Outcomes in Amblyopia: Linking Brain Plasticity With Visual Perceptual Skills

The primary objective of this study is to evaluate the effects of a personalized vision therapy programme tailored to baseline visual-cognitive abilities in treatment-resistant amblyopia. In addition to testing the hypothesis that rehabilitation protocols targeting amblyopia related visual-perceptual and visual-cognitive skills. Spesific aims of this study are:

  1. to identify which visual perceptual skills are most significantly impaired sen patients with amblyopia.
  2. to evaluate whether interventions are targeting fundamental visual perceptual skills are associated with improvements in higher-order visual perceptual skills.
  3. to determine whether vision therapy tailored to individual neuro-visual impairments associated with improvements in binocular function, including streopsis and overall visual perceptual performance.
  4. to ases whether baseline neuro-visual perceptual performance predicts the response to vision therapy in patients with amblyopia.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

38

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

38 amblyopia patients who are admitted to the Dr.Semrin Timlioğlu İper Clinic and Okan University. During the time period: June 2024-June 2025. Patients are unresponsive to traditional treatments such as: strabismus surgery, occlusion therapy and atropinization. They recieved personalized vision therapy programme based on their visual-cognitive and perceptual skills.

Description

Inclusion Criteria:

  • Ambylopia patient
  • Minimal response to traditional treatments
  • Ages between 4-18
  • Receiving personalized vision therapy
  • Taking the TVPS-3 at least 2 times

Exclusion Criteria:

  • Responsive to treatment
  • Discontinued vision therapy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Amblyopia patients enrolled in vision therapy
Amblyopia patients who are unresponsive to treatmens ( occlusion therapy, atropinization, strabismus surgery) and enrolled in vision therapy
Diagnostic test: Motor Free Perception Vision Test
The Motor-Free Visual Perception Test-3 (MVPT-3) represents a significant methodological iteration in the assessment of non-motor visual processing, specifically validated for individuals ranging from 4 to 95 years of age. In pediatric and adolescent contexts (under 18), the MVPT-3 is utilized to isolate cognitive visual-perceptual skills-such as spatial relationships, visual discrimination, figure-ground, and visual closure-from fine motor coordination, which may still be developing or impaired. The test consists of 65 items arranged in a horizontal format to accommodate individuals with hemispatial neglect or limited field of vision. For younger examinees, the assessment is particularly vital for identifying perceptual deficits that may impede academic performance, such as reading fluency or mathematical reasoning, without the results being skewed by the child's handwriting or drawing abilities. By providing age-adjusted normative data, the MVPT-3 allows clinicians to derive standard

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
The Correlation Between Vision Therapy and Visual Cognitive Skills and It's Therapeutic Results in Amblyopia: Associating with Brain Plasticity and Visual Perceptual Skills
Time Frame: From June 2024 to June 2025
From June 2024 to June 2025

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Okan University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 12, 2024

Primary Completion (Actual)

June 12, 2025

Study Completion (Actual)

September 30, 2025

Study Registration Dates

First Submitted

February 23, 2026

First Submitted That Met QC Criteria

February 23, 2026

First Posted (Actual)

February 27, 2026

Study Record Updates

Last Update Posted (Actual)

March 10, 2026

Last Update Submitted That Met QC Criteria

March 7, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 56664061-050.01.04-E.2309

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

All IPD that underlie results in publication

IPD Sharing Access Criteria

Open access for academics

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • ICF
  • ANALYTIC_CODE
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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