Peeling of the Internal Limiting Membrane During Primary Vitrectomy for Retinal Detachment Repair

April 12, 2026 updated by: Prim. Prof. Dr. Oliver Findl, MBA, Vienna Institute for Research in Ocular Surgery

Effect of Peeling of the Internal Limiting Membrane on Vision Results After Primary Vitrectomy for Retinal Detachment Repair

Primary vitrectomy for retinal detachment repair is one of the current methods for surgical treatment of retinal detachment. Additional peeling of the internal limiting membrane (ILM) was reported to successfully prevent development of epiretinal membranes after surgery. The aim of the study is to examine the effect of ILM-Peeling on visual acuity outcomes and on occurrence of postoperative epiretinal membranes.

Study Overview

Status

Terminated

Conditions

Intervention / Treatment

Detailed Description

Retinal detachment is a disorder, usually caused by peripheral retinal breaks, that leads to severe decrease in vision in untreated cases. Primary vitrectomy for retinal detachment repair is one of the current methods for surgical treatment of retinal detachment. Recent retrospective studies support the hypothesis, that peeling of the internal limiting membrane (ILM) is beneficial on postoperative visual acuity and lower rates of occurrence of epiretinal membranes after surgery [Forlini et al. 2018].

The aim of the study is to examine the effect of ILM-Peeling on visual acuity outcomes and on occurrence of postoperative epiretinal membranes.

Study Type

Interventional

Enrollment (Actual)

21

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Austria
      • Vienna, Austria, 1140
        • VIROS

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • retinal detachment
  • age: 18 or older
  • written informed consent for surgery and participation in the study prior to surgery

Exclusion Criteria:

  • pregnancy (pregnancy test will be taken preoperatively in women of reproductive age)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: ILM-Peeling
Procedure: ILM-Peeling
during primary vitrectomy for retinal detachment repair additional ILM-Peeling is performed
Active Comparator: No Peeling
Procedure: No Peeling
during primary vitrectomy for retinal detachment repair no additional ILM-Peeling is performed

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
visual acuity
Time Frame: from enrollment to the end of follow-up at 4 years after surgery
from enrollment to the end of follow-up at 4 years after surgery

Secondary Outcome Measures

Outcome Measure
Time Frame
occurrence of epiretinal membranes
Time Frame: from enrollment to the follow-up at 4 years after surgery
from enrollment to the follow-up at 4 years after surgery

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Vienna Institute for Research in Ocular Surgery

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 3, 2019

Primary Completion (Actual)

January 1, 2025

Study Completion (Actual)

January 1, 2025

Study Registration Dates

First Submitted

February 22, 2026

First Submitted That Met QC Criteria

February 22, 2026

First Posted (Actual)

February 27, 2026

Study Record Updates

Last Update Posted (Actual)

April 15, 2026

Last Update Submitted That Met QC Criteria

April 12, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • RD_ILM

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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