Recovery Hypoxemia After Sedated Upper Gastrointestinal Endoscopy

February 25, 2026 updated by: İlke Dolgun, Istinye University

Incidence, Duration, and Clinical Impact of Recovery-Period Hypoxemia Following Sedated Upper Gastrointestinal Endoscopy: A Prospective Observational Study

Sedation during upper gastrointestinal endoscopy may lead to respiratory events not only during the procedure but also in the early recovery period. Although most hypoxemic episodes are considered transient, their frequency, duration, and clinical consequences during recovery remain insufficiently defined.

This prospective observational study aims to evaluate the incidence, duration, and clinical impact of recovery-period hypoxemia following sedated upper gastrointestinal endoscopy. Hypoxemia is defined as SpO₂ <90% lasting ≥10 seconds. Associated respiratory events and potential risk factors will be analyzed without altering routine clinical practice.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Turkey (Türkiye)
    • Merkez Mahallesi
      • Istanbul, Merkez Mahallesi, Turkey (Türkiye), 34250
        • Istinye University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

Adult patients undergoing elective upper gastrointestinal endoscopy (EGD) under anesthesiologist-administered sedation at a single tertiary care endoscopy unit. Participants will be enrolled consecutively and followed prospectively during the immediate recovery period without alteration of routine clinical management.

Description

Inclusion Criteria:

  • Adults aged ≥18 years
  • Scheduled for upper gastrointestinal endoscopy (EGD) under anesthesiologist-administered sedation
  • Able to undergo post-procedure monitoring in the recovery unit
  • Provided written informed consent for participation and data use

Exclusion Criteria:

  • Colonoscopy or combined procedures (EGD + colonoscopy)
  • Emergency procedures or procedures performed under intensive care conditions
  • Requirement for endotracheal intubation, noninvasive ventilation, or advanced airway support during the procedure
  • Known severe upper airway anatomical abnormalities, facial deformity, or tracheostomy
  • Inability or refusal to provide informed consent
  • Incomplete or unavailable recovery-period oxygen saturation monitoring data

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Recovery-Period Respiratory Events
Time Frame: From end of procedure (scope-out) until discharge from recovery unit

Occurrence of respiratory events during the recovery period following sedated upper gastrointestinal endoscopy, defined as at least one of the following:

SpO₂ <90% lasting ≥10 seconds

Requirement for airway maneuver (jaw-thrust, chin-lift, OPA/NPA, mask ventilation)

Escalation or re-initiation of supplemental oxygen
From end of procedure (scope-out) until discharge from recovery unit

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Istinye University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

February 28, 2026

Primary Completion (Estimated)

March 15, 2026

Study Completion (Estimated)

March 20, 2026

Study Registration Dates

First Submitted

February 25, 2026

First Submitted That Met QC Criteria

February 25, 2026

First Posted (Actual)

March 3, 2026

Study Record Updates

Last Update Posted (Actual)

March 3, 2026

Last Update Submitted That Met QC Criteria

February 25, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • endoscopy rox index

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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