Extended Platelet Rich Fibrin Versus Allograft as Space Filling Material

February 25, 2026 updated by: Hala Elnaggar, Mansoura University

Extended Platelet Rich Fibrin Versus Allograft as Space Filling Material in Immediate Dental Implant Placement

Twenty-eight patients seeking prosthetic replacement of non-restorable single rooted maxillary teeth by dental implant will be selected from the outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

28

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Al Mansurah, Egypt, 002
        • Faculty of Dentistry, Mansoura University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  1. Patients with badly destructed teeth due to trauma or caries.
  2. Patients willing to complete the study follow up intervals.
  3. Patients with good oral hygiene.
  4. Adequate inter-arch space that can accommodate implant abutment and future restoration.
  5. No gender preference in selection of the patients.

Exclusion Criteria:

  1. Patients with systemic diseases that absolutely contraindicate dental implant placement.
  2. Patients with parafunctional habits (bruxism and clenching).
  3. Heavy smokers (i.e. More than 20 cigarettes/day)34 and alcoholism.
  4. Presence of local infection or lesions at the proposed area for dental implant.
  5. Pregnancy.
  6. Patient taking drugs that could affect bone healing process as immunosuppressive drugs and bisphosphonates.
  7. Patients with bad oral hygiene and untreated periodontal disease
  8. Uncooperative patients

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Group 1
14 immediate implants placed in the maxillary esthetic zone then placement of allograft in the gap distance around the implant.
Other: Allograft
after immediate implant placement the gap will be filled with allograft
Experimental: Group 2
14 immediate implants placed in the maxillary esthetic zone then placement of e-PRF in the gap distance around the implant.
Other: e-PRF
after immediate implant placement the gap will be filled with e-PRF

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Implant stability
Time Frame: immediately ,6months follow up & one year
Resonance frequency analysis (RFA) values expressed as implant stability quotient (ISQ) will be recorded by (Osstell Mentor Device)
immediately ,6months follow up & one year

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Marginal bone loss
Time Frame: immeditely,6months follow up & one year
CBCT was done to assess the buccal marginal bone loss
immeditely,6months follow up & one year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mansoura University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 1, 2024

Primary Completion (Actual)

September 1, 2024

Study Completion (Actual)

September 1, 2025

Study Registration Dates

First Submitted

February 25, 2026

First Submitted That Met QC Criteria

February 25, 2026

First Posted (Actual)

March 3, 2026

Study Record Updates

Last Update Posted (Actual)

March 3, 2026

Last Update Submitted That Met QC Criteria

February 25, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • A0303024OS

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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