Laparoscopic Versus Open Nephrectomy : Clinical Effectivness and Cost Analysis

March 9, 2026 updated by: Haitham Badr elnaggar, Menoufia University
To evaluate and compare clinical effectiveness (operative time, blood loss, hospital stay, complications and etc) and cost analysis' between laparoscopic nephrectomy and open nephrectomy .

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Egypt
    • Shebin Elkom
      • Shibīn al Kawm, Shebin Elkom, Egypt, 32111
        • Recruiting
        • Menoufia Faculty of Medicine
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • American Society of Anesthesiology score 1-3.

  • Indication for :

    • Simple total nephrectomy or hemi nephrectomy: benign chronic inflammatory non-functioning kidney
    • Partial nephrectomy: localized renal mass ≤7 cm suitable for nephron-sparing surgery.
    • Radical nephrectomy or Radical nephrouretrectomy with bladder cuff: localized renal tumor requiring complete nephrectomy without major vascular invasion.
  • Patient deemed fit for general anesthesia and surgery.
  • Patient provides written informed consent.

Exclusion Criteria:

  • emergency surgery, dialysis-dependent patients, planned hybrid procedures.
  • Patients with incomplete data
  • Patients with metastatic disease at presentation.
  • Prior extensive ipsilateral retroperitoneal surgery or severe adhesions precluding Laparoscopy.
  • Need for concomitant major procedures (eg, large bowel resection) at index operation.
  • Locally advanced tumor with obvious major vascular involvement requiring complex vascular reconstruction.
  • Uncorrected coagulopathy.
  • Pregnancy or Obese patient (BMI > 40)
  • Inability to provide informed consent or comply with follow-up.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: open nephrectomy
Length of hospital stay (LOS) , post operative rehabilitation and cost analysis
Procedure: open or laparoscopic nephrectomy
compare post operative recovery , estimated blood loss and cost analysis between open and laparosopic nephrectomy.
Active Comparator: laparoscopic nephrectomy
Length of hospital stay (LOS) , post operative rehabilitation and cost analysis
Procedure: open or laparoscopic nephrectomy
compare post operative recovery , estimated blood loss and cost analysis between open and laparosopic nephrectomy.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Length of hospital stay (LOS).
Time Frame: 30 days post operative
Number of calendar days from date of index surgery to date of discharge .
30 days post operative

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
clinical effectiveness
Time Frame: Post operative 30 days.

Functional recovery was evaluated using a modified World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0).

The questionnaire consists of 10 items scored on a 5-point scale (0-4), with a total score ranging from 0 to 40, where higher scores indicate worse functional outcome and greater disability while Lower scores indicate better functional recovery.
Post operative 30 days.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Menoufia University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

February 1, 2026

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

February 1, 2027

Study Registration Dates

First Submitted

February 19, 2026

First Submitted That Met QC Criteria

March 4, 2026

First Posted (Actual)

March 10, 2026

Study Record Updates

Last Update Posted (Actual)

March 11, 2026

Last Update Submitted That Met QC Criteria

March 9, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • laparoscopic nephrectomy

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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