Basic and Clinical Research of Pregnancy-Induced Hypertension (BCRPIH)

March 10, 2026 updated by: Second Affiliated Hospital of Wenzhou Medical University

Collect Blood Pressure, Blood, Amniotic Fluid, Placenta and Other Samples From Normal Pregnant Women, Patients With Pregnancy-induced Hypertension and Those Who Have Experienced Miscarriage, and Conduct Tests on Them.

Collect blood pressure, blood, amniotic fluid, placenta and other samples from normal pregnant women, patients with pregnancy-induced hypertension and those who have experienced miscarriage, and conduct tests on them.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • China
    • Zhejiang
      • Wenzhou, Zhejiang, China, 325000
        • Recruiting
        • The Second Affiliated Hospital of Wenzhou Medical University
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Healthy parturient women, women who have had miscarriages, patients with pregnancy-induced hypertension

Description

Inclusion Criteria:

- Healthy pregnant women, patients with miscarriage, etc.

Exclusion Criteria:

  • Heart disease, infections, etc. in pregnant women Uncooperative patients

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
control group
Healthy pregnant women
Other: no Intervention
observation
PIH group
Pregnancy-induced hypertension patients
Other: no Intervention
observation

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
PIH
Time Frame: Early pregnancy：Weeks 1 to 12 (the first to third months of pregnancy) ；mid-pregnancy：Weeks 13 to 27 (the 4th to 6th month of pregnancy) ；post-delivery period：Weeks 28 to 40 (the 7th to 9th months of pregnancy)；the day of delivery。
the content of GPR18 type macrophages
Early pregnancy：Weeks 1 to 12 (the first to third months of pregnancy) ；mid-pregnancy：Weeks 13 to 27 (the 4th to 6th month of pregnancy) ；post-delivery period：Weeks 28 to 40 (the 7th to 9th months of pregnancy)；the day of delivery。

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
PIH
Time Frame: delivery
Blood pressure
delivery
PIH
Time Frame: delivery
SPM content
delivery
PIH
Time Frame: delivery
Spiral artery morphology
delivery

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Second Affiliated Hospital of Wenzhou Medical University

Investigators

  • Study Chair: Qian Wang, The Second Affiliated Hospital of wenzhou Medical University Longwan Branch

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2020

Primary Completion (Estimated)

December 31, 2027

Study Completion (Estimated)

December 31, 2028

Study Registration Dates

First Submitted

January 5, 2026

First Submitted That Met QC Criteria

March 10, 2026

First Posted (Actual)

March 11, 2026

Study Record Updates

Last Update Posted (Actual)

March 11, 2026

Last Update Submitted That Met QC Criteria

March 10, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • SAHoWMU-CR2025-03-134

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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