Comparing Effects of HIIT and MICT on Functional Mobility, Muscle Strength, and Quality of Life in Diabetic Patients

Comparing The Effects of High Intensity Interval Training and Moderate Intensity Continuous Training on Functional Mobility, Muscle Strength, and Quality of Life in Diabetic Patients

To compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) on functional mobility, muscle strength, and quality of life in individuals with type-2-diabetes.

Study Overview

• Status: Not yet recruiting
• Conditions: Type 2 Diabetes Mellitus With Complication
• Intervention / Treatment: Other: High Intensity Interval Training; Other: Moderate Intensity Continuous Training

Detailed Description

Comparing the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on functional mobility, muscle strength, and quality of life in diabetic patients is important due to the increasing burden of diabetes and its associated complications. Diabetes often leads to reduced physical function, muscle weakness, and poor quality of life. While both HIIT and MICT have demonstrated positive effects on health outcomes, it is not yet clear which exercise regimen offers superior benefits for improving mobility, strength, and overall well-being in diabetic individuals.

Diabetes often leads to reduced physical function, muscle weakness, and poor quality of life. While both HIIT and MICT have demonstrated positive effects on health outcomes, it is not yet clear which exercise regimen offers superior benefits for improving mobility, strength, and overall well-being in diabetic individuals. Understanding this can guide the development of more effective exercise protocols for diabetes management.

• Study Type: Interventional
• Enrollment (Estimated): 28
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Imran Amjad, Phd.; Phone Number: 03324390125; Email: imran.amjad@riphah.edu.pk

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria

:• Adults aging form 35 to 65.

• Both male and female diabetic patients.
• Individuals diagnosed with type 2 diabetes for at least five years.
• Individuals able to participate in moderate to intense physical activity.

Exclusion Criteria:

• • Individuals with significant orthopedic limitations.

  • Individuals with uncontrolled cardiovascular disease or musculoskeletal issues.
  • Individuals with incontinence issues during physical activity or inability to comply to study protocols

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: High Intensity Interval Training; Warm-up: - 5 minutes of dynamic stretching.Exercise Intervals- 4 sets of 4 minutes high-intensity exercises (i.e, sprint intervals on a treadmill and squat jumping) - Intensity: Corresponding to perceived exertion rating (RPE) of 15-18 on the Borg 6-20 scale (32).Cool-down:- 3 minutes of active recovery intervals- Intensity: Rating of perceived exertion (RPE) 8 to 10.Schedule:- Frequency: 3 times per week- Duration: 12-week period- Total session duration: 30-32 minutesObjective:- Focus on maximizing cardiovascular and muscular adaptations through brief, intense activity bursts.	Other: High Intensity Interval Training; 3 session per week, 12 weeks sessions continued, each session had 4 sets of 4 minutes exercise with 3 min active rest inbetween routines. total 30 minutes per session, Sprinting and Jump squatting RPE 15-18
Active Comparator: Moderate Intensity Continuous Training; Warm-up:- 5 minutes of dynamic stretching.Continuous Exercise:- 40 minutes of moderate-intensity exercises (i.e., brisk walking on a treadmill) - Intensity: Perceived exertion rate of 11-13 on the Borg 6-20 scale (34).Cool-down: None (continuous without intervals)Schedule:- Frequency: 3 times per week- Duration: 12-week period- Total session duration: 45 minutesObjective:- Promote endurance and quality of life with a sustainable approach to improving overall physical endurance.	Other: Moderate Intensity Continuous Training; 3 session per week, 12 weeks sessions continued, 40 minutes one single exercise regime with no intervals. Brisk Walking on Treadmill, RPE-11-13

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
TUG timed up go test	Functional mobility is evaluated by the TUG test. The TUG test has revealed very high test-retest reliability among patients with diabetes, as shown by the ICC values from 0.93 to 0.99	baseline pre exam, 6th week of intervention, and 12th week
Hand Grip Strength Test	To assess the power of muscles a dynamometer used to test the gripping power of participants making an objective estimate of the strength of the muscles in the upper body. This method had the same validity as that of the whole functional capacity in diabetic populations, with coefficients of 0.70 to 0.85 being most common	baseline pre exam, 6th week of intervention, and 12th week
Chair Stand Test	In order to evaluate again the strength of the lower limb muscles. The individuals were measured how fast they could stand up from a chair and sit down again and again, which is an indicator of muscle endurance and functional strength. The test has shown really high reliability in diabetic populations with ICC values being around 0.85 to 0.91.	baseline pre exam, 6th week of intervention, and 12th week
The Borg 6-20 Scale	The Borg 6-20 scale used to measure the rate of perceived exertion. It has a strong relationship with heart rate and oxygen consumption with the range of correlation coefficients between 0.80 and 0.88 for diabetic individuals. The Borg RPE scale in T2DM has a test-retest reliability indicated by the Intraclass Correlation Coefficient (ICC) of about 0.85 to 0.92, which means that people give similar ratings of their exertion consistently across repeated sessions in similar exercise conditions	baseline pre exam, 6th week of intervention, and 12th week
WHOQOL-BREF Questionnaire	The WHOQOL-BREF is a universal instrument that measures the quality of life in different aspects such as physical health, psychological health, social relationships, and environment. In patients with diabetes, the WHOQOL-BREF reveals a strong internal consistency with Cronbach's alpha values ranging from 0.76 to 0.88	baseline pre exam, 6th week of intervention, and 12th week

Collaborators and Investigators

• Sponsor: Riphah International University
• Investigators: Principal Investigator: Sobia Kanwal, tDPT, Riphah International University

Study record dates

Study Major Dates

• Study Start (Estimated): March 5, 2026
• Primary Completion (Estimated): July 17, 2026
• Study Completion (Estimated): September 22, 2026

Study Registration Dates

• First Submitted: March 16, 2026
• First Submitted That Met QC Criteria: March 16, 2026
• First Posted (Actual): March 20, 2026

Study Record Updates

• Last Update Posted (Actual): March 20, 2026
• Last Update Submitted That Met QC Criteria: March 16, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Keywords: muscles weakness, disability, reduced quality of life,
• Additional Relevant MeSH Terms: Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Physical Conditioning, Human; Exercise; High-Intensity Interval Training
• Other Study ID Numbers: REC/RCR & AHS/24/02110

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No