A Functional Near- Infrared Spectroscopy Study on the Brain Activation Characteristics of Stroke Patients During Mirror Movement

After the selected patients are determined, the researchers of this study need to have full communication with the patients. The location is the rehabilitation ward of our hospital and the time is

Before joining the group. During this process, the patient should be informed of the purpose, procedures and processes of the trial. The informed consent form should be signed by the patient himself/herself. Such as the patient

Illiterate, the informed consent process was witnessed by an independent witness and signed. The subject pressed their fingerprint at the signature. In the study process fully

Listen to and respond to the questions and opinions of the subjects or their representatives.

Study Overview

• Status: Recruiting
• Conditions: Stroke; Upper Limb Function
• Intervention / Treatment: Behavioral: healthy hand movement; Device: mirror image

• Study Type: Observational
• Enrollment (Estimated): 25

Contacts and Locations

• Study Contact: Name: Jiasheng Zhu, Bachelor's; Phone Number: +86 15157177433; Email: zhujiasheng321@sina.com
• Study Contact Backup: Name: Yifei Xia, master's; Phone Number: +86 19816890266; Email: 2523084@zju.edu.cn

Study Locations

• China
  • Hangzhou, China
    • Recruiting
    • The Second Affiliated Hospital of Zhejiang University School of Medicine
    • Contact: Jiasheng Zhu; Phone Number: 15157177433; Email: zhujiasheng321@sina.com
    • Contact: Yifei Xia; Phone Number: 19816890266; Email: 2523084@zju.edu.cn

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

The main population of this study consists of individuals aged between 30 and 80 years old who have experienced a stroke for the first time and have residual upper limb dysfunction. There is no limit to the age range.

Description

Inclusion Criteria:

• It meets the diagnostic criteria of the "Guidelines for the Prevention and Treatment of Cerebrovascular Diseases in China", and is diagnosed as cerebral infarction or cerebral hemorrhage by CT or MRI.
• The first stroke occurred;
• The muscle strength of the flexor and extensor muscles of the affected finger is ≤ grade 1.
• Right-handed player
• Muscle tone improvement: Asworth level 2 or below;
• The disease course is within 6 months and the condition is stable.
• Age: 18 to 75 years old, with normal vision and hearing or corrected to normal.

Exclusion Criteria:

• Those with an MMSE score less than 20, severe memory, communication and speech command comprehension disorders, and those who cannot cooperate with examinations and treatments;
• Those with a history of epilepsy;
• Those with a history of stroke, traumatic brain injury or brain tumor in the past;
• Those with peripheral nervous system injuries other than stroke as diagnosed by imaging;
• Those with visual spatial impairments such as visual field defects and unilateral neglect;
• Skull defect or metal bone plates
• For those who are not suitable for functional near-infrared examination;
• Those with a history of intracranial surgery.
• Patients with lesion areas in the cerebellum or brainstem.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
normal hand movement	Behavioral: healthy hand movement; Patient will be asked to quickly open and grasp the healthy hand, and keep their eyes on the affected hand.
mirror hand movement	Device: mirror image; Patients will be asked to place the affected hand in the mirror box. While quickly opening and closing the healthy hand, they should observe the reflection of the healthy hand in the mirror and imagine the affected hand doing the same movements.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
fNIRS measured brain activation	The measurement of the primary outcome indicators occurred after the patients had received one week of hand function rehabilitation training.

Collaborators and Investigators

• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2024
• Primary Completion (Estimated): May 1, 2030
• Study Completion (Estimated): October 1, 2030

Study Registration Dates

• First Submitted: May 6, 2025
• First Submitted That Met QC Criteria: March 29, 2026
• First Posted (Actual): April 3, 2026

Study Record Updates

• Last Update Posted (Actual): April 3, 2026
• Last Update Submitted That Met QC Criteria: March 29, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Stroke
• Other Study ID Numbers: yan-2025-0018

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No