- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT07530900
Prediction of Visual Feedback Effects on Speech Motor Adaptation in Healthy Adults (PVF)
Prediction of Visual Feedback Gain in Altered Auditory Feedback Tasks Using Computational Modeling
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
During speech, the brain relies on multiple sources of feedback, including auditory input and physical sensations from the tongue and lips, to monitor and adjust speech in real time. People differ in how much they rely on each of these feedback sources, and these individual differences may predict who benefits most from different types of technological support for speech learning.
This study examines whether a computational model of individual response to sensory feedback can predict how much a person benefits from the addition of real-time visual feedback during a speech task. Participants will complete a series of tasks in which auditory feedback of speech is altered in real time through headphones. A computational model is then used to estimate how strongly each participant relies on hearing versus physical sensation when monitoring speech. Participants then repeat the task with an added visual display showing the speech signal alongside a target, providing an additional source of feedback.
The primary question is whether the computational profile of sensory feedback use - specifically, whether a person relies more heavily on hearing or on physical sensation - predicts how much the visual display improves each participant's ability to respond to the altered feedback.
At baseline, participants complete two versions of an altered auditory feedback (AAF) task without visual feedback. The first uses a "fast adapt" design in which altered feedback is introduced and withdrawn repeatedly across short experimental runs; the second uses a standard adaptive design in which the altered feedback is introduced once and maintained for a longer run. Performance in both tasks is submitted to SimpleDIVA computational modeling to estimate participant-specific auditory and somatosensory response parameters. The use of two task variants allows evaluation of the stability of parameter estimates across elicitation conditions.
Participants then complete a standard adaptive AAF task with simultaneous real-time visual-acoustic biofeedback. The visual display presents the current audio playback signal (i.e., the altered signal) alongside a visual target derived from the participant's baseline production. The primary outcome measure is visual gain, defined as the within-participant difference in compensation magnitude between the auditory-visual feedback condition and the auditory-only condition of the standard adaptive AAF task.
The primary analysis uses linear regression to test whether SimpleDIVA parameters from the baseline phase predict the magnitude of visual gain. The predictor of primary interest is the ratio of auditory to total sensory weighting, reflecting the relative dominance of auditory versus somatosensory feedback. Baseline compensation magnitude in the auditory-only condition will be included as a covariate. A paired-samples t-test will also evaluate the overall effect of adding visual feedback on compensation magnitude across the sample.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Tara McAllister, PhD
- Phone Number: 212-992-9445
- Email: tkm214@nyu.edu
Study Locations
-
-
New York
-
New York, New York, United States, 10012
- Recruiting
- New York University
-
Contact:
- Tara McAllister, PhD
- Email: tkm214@nyu.edu
-
Principal Investigator:
- Tara McAllister, PhD
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Age 18 to 45 years
- Self-reported English as dominant or equally dominant language (learned English by age 3)
- No self-reported history of significant speech, language, or hearing difficulty
- Pass pure-tone hearing screening at 25 dB HL
- Pass qualitative screening of speech, voice, and resonance based on connected speech sample
Exclusion Criteria:
- Learned English after age 3
- English is not a dominant language
- History of speech or language disorder, hearing loss, or neurodevelopmental disorder (e.g., autism spectrum disorder, Down syndrome)
- Failure to pass pure-tone hearing screening
- Failure to pass qualitative screening of speech, voice, and resonance
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Experimental: Altered Auditory Feedback With and Without Visual Feedback
All participants complete altered auditory feedback tasks without visual feedback (baseline phase) followed by the same task with simultaneous real-time visual-acoustic biofeedback.
Both conditions are administered within a single study visit.
|
Participants produce speech while hearing real-time altered auditory feedback delivered through headphones.
Two task variants are administered: a fast-adapt design in which the altered feedback is introduced and withdrawn repeatedly, and a standard adaptive design in which the altered feedback is introduced once and maintained for an extended run.
Administered to all participants as the baseline condition.
Participants perform the standard adaptive auditory feedback task with the addition of real-time visual display.
The visual display presents the altered auditory signal alongside a visual target derived from the participant's baseline production.
Administered to all participants following the auditory-only baseline phase.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Mean difference in F1 compensation magnitude between auditory-visual and auditory-only feedback conditions of standard adaptive feedback task
Time Frame: During study visit (Day 1)
|
Visual gain is defined as the within-participant difference in acoustic compensation magnitude (measured from formant frequencies) between the auditory-visual feedback condition and the auditory-only condition of the standard adaptive feedback task.
Greater visual gain indicates a larger compensatory response when visual feedback is available.
|
During study visit (Day 1)
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Tara McAllister, PhD, New York University
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- PVF-Aim3
- 1R01DC017476 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Time Frame
IPD Sharing Access Criteria
IPD Sharing Supporting Information Type
- ANALYTIC_CODE
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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