- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02094014
Auditory Masking Effects on Speech Fluency in Aphasia and Apraxia of Speech
Study Overview
Status
Conditions
Detailed Description
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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North Carolina
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Chapel Hill, North Carolina, United States, 27599-7190
- University of North Carolina School of Medicine
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria for Aphasic/Apraxic Participants:
- Single left-hemisphere cerebrovascular accident
- Speech errors are present, but participant is able to produce approximations of words or sentences by reading or repetition; < 90% and > 10% on Chapel Hill Multilingual Intelligibility Test (Haley, 2011)
- Right-handed prior to stroke by report
- Normal visual attention, acuity, and color vision
- Pure-tone threshold <= 40 decibels in at least one ear
Exclusion Criteria for Aphasic/Apraxic Participants:
- Predominating disorders of cognition or hearing (e.g. dementia, hearing impairment).
- Presence of degenerative neurological illness (e.g. Parkinson's disease, amyotrophic lateral sclerosis, primary progressive aphasia).
Inclusion Criteria for Neurologically Healthy Participants:
- Matched in age and sex to a participant with aphasia
- score of 90% or higher on the single-word intelligibility test
- Right-handed prior to stroke by report
- Normal visual attention, acuity, and color vision
- Pure-tone threshold <= 40 decibels in at least one ear
Exclusion Criteria for Neurologically Healthy Participants:
- History of stroke
- History of developmental speech or language disorder
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Aphasic/Apraxic Participants
The aphasic/apraxic participant group will include 30 adults who have had strokes affecting their ability to communicate verbally, broadly classified as aphasic and including individuals with and without apraxia of speech (AOS). Participants will speak under Masked Auditory Feedback, Altered Auditory Feedback, and Normal Auditory Feedback. |
Participants will produce sentences under normal speaking conditions, able to hear their own speech.
Participants will produce sentences while listening to speech-shaped noise at 85 decibels (sound pressure level) to mask ability to hear their own speech.
Other Names:
Participants will produce sentences while listening to their speech shifted up one octave and delayed.
Other Names:
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Neurologically Healthy Participants
The neurologically healthy participant group will include 15 adults with no history of stroke or developmental speech or language disorder. Participants will speak under Masked Auditory Feedback, Altered Auditory Feedback, and Normal Auditory Feedback. |
Participants will produce sentences under normal speaking conditions, able to hear their own speech.
Participants will produce sentences while listening to speech-shaped noise at 85 decibels (sound pressure level) to mask ability to hear their own speech.
Other Names:
Participants will produce sentences while listening to their speech shifted up one octave and delayed.
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Disfluency duration change with masking noise
Time Frame: 1 day of the study
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Measured disfluency duration in sentences produced while listening to masking noise compared to speaking in quiet without noise.
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1 day of the study
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Speech rate change with masking noise
Time Frame: 1 day of the study
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Measured syllables per second in sentences produced while listening to masking noise compared to speaking in quiet without noise.
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1 day of the study
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Speech sound accuracy change with masking noise
Time Frame: 1 day of the study
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Measured speech sound accuracy in sentences produced while listening to masking noise compared to speaking in quiet without noise.
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1 day of the study
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Collaborators and Investigators
Investigators
- Principal Investigator: Adam Jacks, Ph.D., University of North Carolina, Chapel Hill
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Cardiovascular Diseases
- Vascular Diseases
- Cerebrovascular Disorders
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- Neurologic Manifestations
- Neurobehavioral Manifestations
- Psychomotor Disorders
- Language Disorders
- Communication Disorders
- Speech Disorders
- Stroke
- Aphasia
- Apraxias
Other Study ID Numbers
- 10-0503
- R03DC011881 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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