The Role of Auditory Feedback in Guiding Upper Extremity Movements

March 26, 2014 updated by: Sunnybrook Health Sciences Centre

Stroke is one of the leading causes of disability, with an estimated prevalence of 50,000 cases per year in Canada. Less than half of stroke patients regain use of their arm and hand. There is currently no intervention regime that is the gold standard, despite the variety of therapeutic techniques used to treat the upper extremity post-stroke. The use of external feedback to improve motor learning is a technique that has been less studied but shows promise. Therefore, the purpose of this proof of principle study it to test whether different auditory feedback frequencies can facilitate reaching ability in people with stroke. In addition brain scans will be collected that will enable us to determine how stroke severity may impact on one's ability to improve with this technique.

We hypothesize that patients who receive less feedback (50% alternate) will have enhanced learning relative to the patients who receive more feedback (100%).

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

26

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Canada
    • Ontario
      • Toronto, Ontario, Canada, M4N 3M5
        • Sunnybrook Health Sciences Centre

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

30 years to 85 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Unilateral first time MCA ischemic stroke
  • Stroke patients should have some movement of shoulder/elbow (no movement of hand - e.g. hand, fingers - is OK)
  • > 2 months post
  • between 30-85 years

Exclusion Criteria:

  • prior stroke
  • severe comprehension (or cognitive) deficit that compromises informed consent or understanding of instructions
  • contraindications to MRI (e.g. claustrophobia, metal implants)
  • neurodegenerative or psychiatric disease
  • apraxia
  • auditory deficits that would impair testing
  • prior musculoskeletal injury to back or upper extremity (including shoulder subluxation from stroke)
  • skin conditions that would preclude taping of goniometers

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Patients

Patients will receive:

Auditory Feedback 100% Auditory Feedback 50% alternate
Behavioral: Auditory Feedback 100%
Patients will receive constant auditory feedback across training trials.
Behavioral: Auditory Feedback 50% alternate
Patients will receive alternating auditory feedback (1 trial auditory feedback; 1 trial no auditory feedback) across trials

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Change in movement error from baseline
Time Frame: participants will be followed for the duration of the study, an expected 3 hours per day for 2 weeks (5 days per week/10 days total)
participants will be followed for the duration of the study, an expected 3 hours per day for 2 weeks (5 days per week/10 days total)

Secondary Outcome Measures

Outcome Measure
Time Frame
Change in range of motion
Time Frame: participants will be followed for the duration of the study, an expected 3 hours per day for 2 weeks (5 days per week/10 days total)
participants will be followed for the duration of the study, an expected 3 hours per day for 2 weeks (5 days per week/10 days total)
Change in movement duration
Time Frame: participants will be followed for the duration of the study, an expected 3 hours per day for 2 weeks (5 days per week/10 days total)
participants will be followed for the duration of the study, an expected 3 hours per day for 2 weeks (5 days per week/10 days total)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sunnybrook Health Sciences Centre

Investigators

  • Principal Investigator: Joyce Chen, PhD, Canadian Partnership for Stroke Recovery

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2014

Primary Completion (Anticipated)

September 1, 2015

Study Completion (Anticipated)

September 1, 2015

Study Registration Dates

First Submitted

March 14, 2014

First Submitted That Met QC Criteria

March 26, 2014

First Posted (Estimate)

March 31, 2014

Study Record Updates

Last Update Posted (Estimate)

March 31, 2014

Last Update Submitted That Met QC Criteria

March 26, 2014

Last Verified

March 1, 2014

More Information

Terms related to this study

Other Study ID Numbers

  • JCH-1234-SF

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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