Comparison of Patient Understanding and Anxiety According to the Delivery Method of Educational Videos

Comparison of Patient Understanding and Anxiety According to the Delivery Method of Educational Videos: A Prospective Randomized Study in Radiotherapy Patients

This study aims to evaluate whether a generative artificial intelligence (AI)-based educational video is more effective than a conventional video in improving patient understanding and reducing anxiety before radiation therapy.

In this prospective, randomized controlled study, participants will be assigned in a 1:1 ratio to either an AI-based avatar video group or a conventional video group consisting of PowerPoint slides with voice narration. Both videos will be standardized to have similar duration (approximately 5 minutes), identical key messages, and the same summary points.

After providing informed consent, participants will complete questionnaires before and after watching the assigned video, as well as during the first week of treatment. Outcomes will include anxiety levels, knowledge comprehension, and satisfaction with the educational video.

A total of 136 patients scheduled to undergo radiation therapy will be enrolled from two institutions. The findings of this study are expected to provide evidence on the effectiveness of AI-based educational tools in enhancing patient education and reducing pre-treatment anxiety.

Study Overview

• Status: Recruiting
• Conditions: Radiotherapy; Patient Education
• Intervention / Treatment: Other: AI-based educational video; Other: Conventional educational video (PPT + narration)

Detailed Description

This study is a prospective, randomized, parallel-group trial designed to evaluate the effectiveness of a generative artificial intelligence (AI)-based educational video compared with a conventional video in patients undergoing radiation therapy.

Participants will be randomly assigned in a 1:1 ratio to one of two groups: (A) an AI-based avatar video group or (B) a conventional video group consisting of PowerPoint slides with voice narration. Both videos will be standardized to ensure comparable duration (approximately 5 minutes), identical core content, and equivalent summary points to minimize variability in information delivery.

After providing informed consent, participants will be asked to complete structured questionnaires at three time points: before viewing the video (baseline), immediately after viewing the video, and during the first week of radiation therapy. The assessments will include measures of anxiety, knowledge comprehension, and satisfaction with the educational material. Baseline assessments will be used as reference values for evaluating changes over time.

The primary objective is to compare post-intervention anxiety levels between the two groups. Secondary objectives include comparisons of knowledge comprehension, satisfaction with the educational video, and changes in anxiety over time.

Statistical analyses will be performed based on the intention-to-treat principle. Descriptive statistics will be used to summarize baseline characteristics. Changes in outcomes over time and between groups will be analyzed using appropriate statistical models for repeated measures. Missing data will not be imputed; analyses will be conducted using available data for each outcome measure.

This study will be conducted at two institutions and aims to provide evidence on whether AI-based educational tools can improve patient understanding and reduce anxiety in the clinical setting.

• Study Type: Interventional
• Enrollment (Estimated): 136
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: HwaKyung Byun, MD, PhD; Phone Number: +82-31-5189-8166; Email: hkbyun05@yuhs.ac

Study Locations

• South Korea
  • Yongin-si, South Korea, 365
    • Recruiting
    • Yongin Severance Hospital
    • Contact: Hwakyung BYUN, professor; Phone Number: 03151898891; Email: hkbyun05@yuhs.ac

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Age ≥ 20 years
• Patients scheduled for radiotherapy
• Ability to watch video and comprehend audio, as assessed by the investigator
• ECOG performance status 0-1

Exclusion Criteria:

• Patients unable to complete questionnaires due to cognitive impairment or psychiatric disorders

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: AI-based Avatar Video; Description: Participants will watch a generative AI-based educational video delivered through an avatar format. The video explains radiotherapy procedures, expected side effects, and self-care information. Duration is approximately 5 minutes. Intervention Type: Other Intervention Name: AI-based educational video Intervention Description: A standardized educational video generated using artificial intelligence avatar technology, designed to improve patient understanding and reduce anxiety prior to radiotherapy.	Other: AI-based educational video; Standardized 5-minute educational video delivered via AI-generated avatar to explain radiotherapy procedures, expected side effects, and self-care information. Designed to improve patient understanding and reduce anxiety.; Other Names: Generative AI avatar video
Active Comparator: PPT + Voice Narration Video; Description: Participants will watch a conventional educational video consisting of PowerPoint slides with voice narration. Content, duration (~5 minutes), and key messages are equivalent to the experimental arm. Intervention Type: Other Intervention Name: Conventional educational video (PPT + narration) Intervention Description: A traditional educational video using slide-based presentation with voice narration covering radiotherapy-related information.	Other: Conventional educational video (PPT + narration); 5-minute educational video using PowerPoint slides with voice narration covering identical content as the AI-based video, including radiotherapy procedures, side effects, and self-care information.; Other Names: Slide-based narrated video

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Anxiety score (APAIS)	Anxiety will be measured using the Amsterdam Preoperative Anxiety and Information Scale (APAIS) (total score range: 6-30; higher scores indicate greater anxiety). Change from baseline will be analyzed using a linear mixed model.	T1(Immediately after the intervention /during the pre-treatment consultation visit)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Anxiety level (K-HADS-A)	Anxiety will be measured using the Korean version of the Hospital Anxiety and Depression Scale - Anxiety subscale (K-HADS-A) (score range: 0-21; higher scores indicate greater anxiety). Change from baseline will be analyzed using a linear mixed model.	T1(Immediately after the intervention (during the pre-treatment consultation visit)
Anxiety level (APAIS, K-HADS-A)	Anxiety will be measured using both APAIS an d K-HADS-A during the first week of treatment. Baseline scores assessed Anxiety will be measured using the Amsterdam Preoperative Anxiety and Information Scale (APAIS) (6-30; higher = greater anxiety) and the Korean version of the Hospital Anxiety and Depression Scale - Anxiety subscale (K-HADS-A) (0-21; higher = greater anxiety). Change from baseline will be analyzed using a linear mixed model.	T2(During the first week of treatment)
Knowledge score	Knowledge will be assessed using a structured questionnaire (score range: 0-10; higher scores indicate better knowledge). Change from baseline will be analyzed using a linear mixed model.	T1(Immediately after the intervention /during the pre-treatment consultation visit) and T2(during the first week of treatment)
Satisfaction score	Participant satisfaction with the educational intervention will be assessed Satisfaction will be assessed using a standardized questionnaire (score range: 0-10; higher scores indicate greater satisfaction). Change over time will be analyzed using a linear mixed model.	T1(Immediately after the intervention /during the pre-treatment consultation visit) and T2(during the first week of treatment)

Collaborators and Investigators

• Sponsor: Yonsei University
• Collaborators: Severance Hospital
• Investigators: Principal Investigator: Hwakyung Byun, MD,PhD, ongin Severance Hospital

Study record dates

Study Major Dates

• Study Start (Actual): December 1, 2025
• Primary Completion (Estimated): May 28, 2027
• Study Completion (Estimated): November 28, 2027

Study Registration Dates

• First Submitted: April 10, 2026
• First Submitted That Met QC Criteria: April 21, 2026
• First Posted (Actual): April 24, 2026

Study Record Updates

• Last Update Posted (Actual): April 29, 2026
• Last Update Submitted That Met QC Criteria: April 23, 2026
• Last Verified: April 1, 2026

More Information

Terms related to this study

• Keywords: Radiotherapy; Patient Education; Educational Video
• Other Study ID Numbers: 9-2025-0190

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No