Flexible Ureterorenoscopy for Surveillance of Upper Tract Urothelial Carcinoma

Flexible Ureterorenoscopy for Surveillance of Upper Tract Urothelial Carcinoma - A Pilot Study

It is a prospective single-arm pilot study to investigate the safety and feasibility of flexible ureteroscopy under local anaesthesia.

Study Overview

• Status: Not yet recruiting
• Conditions: Upper Tract Urothelial Carcinoma
• Intervention / Treatment: Other: Flexible ureterorenoscopy

Detailed Description

All consecutive patients who have undergone kidney-sparing surgery for managing upper tract urothelial carcinoma will be screened for study eligibility. Surveillance flexible ureteroscopy of the upper urinary tract under local anaesthesia in an ambulatory care setting. The peri-operative outcomes, patient reported outcomes, complication and cost-effectiveness analysis will be evaluated.

• Study Type: Interventional
• Enrollment (Estimated): 10
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Ho Ming Chris WONG, MBChB; Phone Number: 35052625; Email: chriswong@surgery.cuhk.edu.hk

Study Locations

• Hong Kong
  • Hong Kong, Hong Kong
    • Prince of Wales Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

1. Aged 18 years or older
2. Capable of giving informed consent
3. Having undergone an kidney-sparing surgery (endoscopic operation or segmental ureterectomy)

Exclusion Criteria:

1. Allergy to transurethral lidocaine jelly
2. On anticoagulation or anti-platelet medication with contraindications for cessation prior to the procedure
3. Structural abnormalities in the upper urinary tract on the intended side of examination

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Treatment Arm; Flexible ureterorenoscopy for Surveillance of UTUC under local anaesthesia	Other: Flexible ureterorenoscopy; Flexible ureterorenoscopy for Surveillance of UTUC under local anaesthesia

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Procedure success rate	The procedure is completed successfully.	Immediately postoperatively

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Complication rate	Assessed by Clavien Dindo Classification	On day 30
Readmission rate	Assessed by readmission to hospital after discharge	On Day 30

Collaborators and Investigators

• Sponsor: Chinese University of Hong Kong
• Investigators: Principal Investigator: Yuen Chun Jeremy TEOH, MD, Chinese University of Hong Kong

Study record dates

Study Major Dates

• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): March 31, 2028

Study Registration Dates

• First Submitted: April 22, 2026
• First Submitted That Met QC Criteria: April 22, 2026
• First Posted (Actual): April 29, 2026

Study Record Updates

• Last Update Posted (Actual): May 5, 2026
• Last Update Submitted That Met QC Criteria: April 29, 2026
• Last Verified: April 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: CRE-2024.432

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No