Gerofitova cvičební intervence pro starší dospělé se srpkovitou anémií (studie SICKLE-FIT) (SICKLE-FIT)

Experimentální: Cvičení

Každá kohorta 5-8 účastníků bude cvičit 3 dny v týdnu po dobu až 12 týdnů. Cvičení bude virtuální

Behaviorální: Cvičební program Gerofit

Cvičební intervence tele-Gerofit má trénink zaměřený na dodržování pokynů pro fyzickou aktivitu a zahrnuje kardiovaskulární, silový a balanční trénink. Relace budou také zahrnovat komponentu všímavosti, zahřívání, ochlazení a bezpečnostní kontroly. Cvičení jsou přizpůsobena funkčnímu stavu každého člověka. Intenzitu cvičení určí účastníci, kteří během sezení uvedou hodnocení vnímané námahy (RPE) na stupnici od 0 (snadné) do 10 (velmi těžké). Počáteční cvičení začnou s nízkou intenzitou a postupně se budou prodlužovat trvání a intenzita, aby každá osoba mohla dosáhnout doporučené úrovně cvičení svým vlastním tempem. Cvičení se provádí virtuálně přes Zoom. Každá kohorta bude mít 5–8 účastníků. Cvičební program bude po každé kohortě optimalizován s úpravami na základě zpětné vazby účastníků a expertů na cvičení.

Feasibility, as Measured by Number of Participants Completing at Least 50% of the Exercise Sessions

Safety, as Measured by Number of Participants With Moderate or Severe Adverse Events

Number of participants with one or more moderate or severe adverse events within 48 hours after each exercise session.

Acceptability, as Measured by the Number of Participants Reporting the Intervention as Acceptable

Acceptability of the exercise program was measured on a scale of 1-10, where 1= severe dislike and 10 = absolute enjoyment. Reported as the number of participants with scores of 8-10.

Percent of Participants With Clinically Meaningful Change in Mobility as Measured by Usual Gait Speed

Reported as the percent change in usual walking speed on a 4.57 meter (15 feet) walking course.

Percent of Participants With Clinically Meaningful Change in Balance as Measured by Timed Up and Go

Performance test of physical mobility. This measures the number of seconds it takes to stand up from a standard chair (46cm), walk a distance of 10 ft (3 meters), turn back to the chair, and sit down again.

Percent of Participants With Clinically Meaningful Change in Aerobic Endurance as Measured by Six-Minute Walk Test (6MWT)

Measure of aerobic endurance. The participant walks as fast and as safely as possible for 6 minutes with prompts given every minute. Distance traveled in 6 minutes is recorded.

Percent of Participants With Clinically Meaningful Change in Upper Body Strength as Measured by Grip Strength

Measure of upper body strength. Jamar hydraulic hand dynamometer (Jamar Technologies) was used to measure grip strength in triplicate for both hands while subject remains seated. The greatest value was used in analysis.

Percent of Participants With Clinically Meaningful Change in Lower Body Strength as Measured by 30-second Chair Stand

30-second chair stand is a measure lower body strength. The participant sits in a folding chair without arms with chair pressed against the wall and stands up and sits back down with arms across their chest as many times as possible in 30 seconds.

Percent of Participants With Improved Quality of Movement Measured by Functional Movement Screen

Includes deep squat and mobility test of upper and lower extremities. This is measure of squat quality/form.