Gerofit-harjoitusinterventio vanhemmille aikuisille, joilla on sirppisolutauti (SICKLE-FIT-tutkimus) (SICKLE-FIT)

Kokeellinen: Harjoittele

Jokainen 5-8 osallistujan kohortti harjoittelee 3 päivää viikossa enintään 12 viikon ajan. Harjoitukset ovat virtuaalisia

Käyttäytyminen: Gerofit-harjoitusohjelma

Tele-Gerofit-harjoitusinterventiossa on harjoittelu, joka keskittyy fyysisen aktiivisuuden ohjeiden täyttämiseen ja sisältää sydän-, voima- ja tasapainoharjoituksia. Istunnot sisältävät myös mindfulness-komponentin, lämmittelyn, jäähdytyksen ja turvallisuustarkastukset. Harjoitukset räätälöidään jokaisen henkilön toimintatilan mukaan. Harjoitusten intensiteetin määrittävät osallistujat arvioivat koettua rasitusta (RPE) asteikolla 0 (helppo) 10 (erittäin kova) koko harjoituksen ajan. Alkuharjoitukset alkavat alhaisella intensiteetillä ja lisäävät vähitellen kestoa ja intensiteettiä, jotta jokainen voi saavuttaa suositellut harjoitustasot omaan tahtiinsa. Harjoitukset tehdään virtuaalisesti Zoomin kautta. Jokaisessa kohortissa on 5-8 osallistujaa. Harjoitusohjelma optimoidaan jokaisen kohortin jälkeen muokkauksin osallistujien ja harjoitusasiantuntijoiden palautteen perusteella.

Feasibility, as Measured by Number of Participants Completing at Least 50% of the Exercise Sessions

Safety, as Measured by Number of Participants With Moderate or Severe Adverse Events

Number of participants with one or more moderate or severe adverse events within 48 hours after each exercise session.

Acceptability, as Measured by the Number of Participants Reporting the Intervention as Acceptable

Acceptability of the exercise program was measured on a scale of 1-10, where 1= severe dislike and 10 = absolute enjoyment. Reported as the number of participants with scores of 8-10.

Percent of Participants With Clinically Meaningful Change in Mobility as Measured by Usual Gait Speed

Reported as the percent change in usual walking speed on a 4.57 meter (15 feet) walking course.

Percent of Participants With Clinically Meaningful Change in Balance as Measured by Timed Up and Go

Performance test of physical mobility. This measures the number of seconds it takes to stand up from a standard chair (46cm), walk a distance of 10 ft (3 meters), turn back to the chair, and sit down again.

Percent of Participants With Clinically Meaningful Change in Aerobic Endurance as Measured by Six-Minute Walk Test (6MWT)

Measure of aerobic endurance. The participant walks as fast and as safely as possible for 6 minutes with prompts given every minute. Distance traveled in 6 minutes is recorded.

Percent of Participants With Clinically Meaningful Change in Upper Body Strength as Measured by Grip Strength

Measure of upper body strength. Jamar hydraulic hand dynamometer (Jamar Technologies) was used to measure grip strength in triplicate for both hands while subject remains seated. The greatest value was used in analysis.

Percent of Participants With Clinically Meaningful Change in Lower Body Strength as Measured by 30-second Chair Stand

30-second chair stand is a measure lower body strength. The participant sits in a folding chair without arms with chair pressed against the wall and stands up and sits back down with arms across their chest as many times as possible in 30 seconds.

Percent of Participants With Improved Quality of Movement Measured by Functional Movement Screen

Includes deep squat and mobility test of upper and lower extremities. This is measure of squat quality/form.