Intervenção de Exercício Gerofit para Idosos com Doença Falciforme (Estudo SICKLE-FIT) (SICKLE-FIT)

Experimental: Exercício

Cada coorte de 5 a 8 participantes se exercitará 3 dias por semana por até 12 semanas. Sessões de exercícios serão virtuais

Comportamental: Programa de Exercícios Gerofit

A intervenção de exercício tele-Gerofit tem treinamento focado em atender às diretrizes de atividade física e incorporar treinamento cardiovascular, de força e equilíbrio. As sessões também incluirão um componente de atenção plena, aquecimento, relaxamento e verificações de segurança. Os exercícios são personalizados de acordo com o estado funcional de cada pessoa. A intensidade dos exercícios será determinada pelos participantes, fornecendo uma classificação de esforço percebido (RPE) em uma escala de 0 (fácil) a 10 (muito difícil) ao longo da sessão. As sessões iniciais de exercícios começarão em baixa intensidade e aumentarão gradualmente a duração e a intensidade para permitir que cada pessoa alcance os níveis de exercício recomendados em seu próprio ritmo. Os exercícios são feitos virtualmente via Zoom. Cada coorte terá de 5 a 8 participantes. O programa de exercícios será otimizado após cada coorte com modificações baseadas no feedback dos participantes e dos especialistas em exercícios.

Feasibility, as Measured by Number of Participants Completing at Least 50% of the Exercise Sessions

Safety, as Measured by Number of Participants With Moderate or Severe Adverse Events

Number of participants with one or more moderate or severe adverse events within 48 hours after each exercise session.

Acceptability, as Measured by the Number of Participants Reporting the Intervention as Acceptable

Acceptability of the exercise program was measured on a scale of 1-10, where 1= severe dislike and 10 = absolute enjoyment. Reported as the number of participants with scores of 8-10.

Percent of Participants With Clinically Meaningful Change in Mobility as Measured by Usual Gait Speed

Reported as the percent change in usual walking speed on a 4.57 meter (15 feet) walking course.

Percent of Participants With Clinically Meaningful Change in Balance as Measured by Timed Up and Go

Performance test of physical mobility. This measures the number of seconds it takes to stand up from a standard chair (46cm), walk a distance of 10 ft (3 meters), turn back to the chair, and sit down again.

Percent of Participants With Clinically Meaningful Change in Aerobic Endurance as Measured by Six-Minute Walk Test (6MWT)

Measure of aerobic endurance. The participant walks as fast and as safely as possible for 6 minutes with prompts given every minute. Distance traveled in 6 minutes is recorded.

Percent of Participants With Clinically Meaningful Change in Upper Body Strength as Measured by Grip Strength

Measure of upper body strength. Jamar hydraulic hand dynamometer (Jamar Technologies) was used to measure grip strength in triplicate for both hands while subject remains seated. The greatest value was used in analysis.

Percent of Participants With Clinically Meaningful Change in Lower Body Strength as Measured by 30-second Chair Stand

30-second chair stand is a measure lower body strength. The participant sits in a folding chair without arms with chair pressed against the wall and stands up and sits back down with arms across their chest as many times as possible in 30 seconds.

Percent of Participants With Improved Quality of Movement Measured by Functional Movement Screen

Includes deep squat and mobility test of upper and lower extremities. This is measure of squat quality/form.