- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT03631862
Treatment of Newly Diagnosed Peripheral T-cell Lymphoma
12. august 2018 opdateret af: Mingzhi Zhang, Zhengzhou University
A Randomized Controlled Clinical Trial of Apatinib Combined With CHOP Regimen in the Treatment of Newly Diagnosed Peripheral T-cell Lymphoma
The purpose of this study is to evaluate the efficacy and safety of Apatinib Combined With CHOP Regimen(cyclophosphamide, vincristine, epirubicin, prednisone in the treatment of newly diagnosed peripheral T-cell lymphoma.
Studieoversigt
Status
Ukendt
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Patients with peripheral T-cell lymphoma usually have a bad prognosis.
These patients cannot be treated successfully with the conventional CHOP regimen.
Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor.
The investigators have been proceeding this trial to evaluate the efficacy and safety of the Apatinib Combined With CHOP Regimen(cyclophosphamide, vincristine, epirubicin, prednisone in the treatment of newly diagnosed peripheral T-cell lymphoma.
Undersøgelsestype
Interventionel
Tilmelding (Forventet)
100
Fase
- Fase 4
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
-
-
Henan
-
Zhengzhou, Henan, Kina, 450052
- Rekruttering
- Oncology Department of The First Affilliated Hospital of Zhengzhou University
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
14 år til 70 år (Barn, Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Beskrivelse
Inclusion Criteria:
- Age range 14-70 years old; ECOG performance status 0-2.
- Estimated survival time > 6 months.
- Histological confirmed Peripherial T-cell lymphoma.
- Have taken no treatment.
- None of chemotherapy contraindication: hemoglobin ≥ 90 g/dl, neutrophil ≥ 1.5×109/L, platelet ≥ 100×109/L, ALT and AST ≤ 2×ULN, serum bilirubin ≤ 1.5×ULN, serum creatine ≤ 1.5×upper limitation of normal (ULN), Serum Albumin ≥ 30g/L, serum plasminogen is normal.
- At least one measurable lesion.
- None of other serious diseases, cardiopulmonary function is normal.
- Pregnancy test of women at reproductive age must be negative.
- Patients could be followed up.
- None of other relative treatments including the traditional Chinese medicine, immunotherapy, biotherapy except anti-bone metastasis therapy and other symptomatic treatments.
- Volunteers who signed informed consent.
Exclusion Criteria:
- Patients with contraindications (active bleeding, ulcers, intestinal perforation, intestinal obstruction, 30 days after major surgery, hypertension uncontrollable drugs, grade III-IV cardiac insufficiency, severe liver and kidney dysfunction);
- Abnormal coagulation (INR > 1.5 or prothrombin time (PT) > ULN + 4 seconds or APTT > 1.5 ULN), with bleeding tendency or undergoing thrombolysis or anticoagulant therapy;
- Urine routine indicates urinary protein ≥ ++, or confirmed 24-hour urine protein ≥ 1.0 g;
- Disagreement on blood sample collection.
- Patients allergic of any of drug in this regimen or with metabolic disorder.
- Pregnant or lactating women.
- Serious medical illness likely to interfere with participation.
- Serious infection.
- Primitive or secondary tumors of central nervous system.
- Chemotherapy or radiotherapy contraindication.
- The evidence of CNS metastasis.
- History of peripheral nervous disorder or dysphrenia.
- Patients participating in other clinical trials.
- Patients taking other antitumor drugs.
- Patients estimated to be unsuitable by investigator.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Eksperimentel: Apatinib combined with CHOP regimen
Apatinib: 250mg/d d1-21 po CHOP regimen(Cyclophosphamide,Vincristine,Epirubicin,Prednisone) : Cyclophosphamide 750mg/d,ivgtt, d1;Vincristine,1.4g/m2,ivgtt,
d1;Epirubicin,60mg/m2,ivgtt,d1;Prednisone 60mg/m2,po, d1-5
|
Apatinib is an orally administrated small molecule receptor tyrosine kinase inhibitor selectively targeting VEGFR-2, showing anti-tumor activity across a broad range of advanced cancers.
Andre navne:
CHOP regimen(Cyclophosphamide,Vindesine,Epirubicin,Prednisone)
Andre navne:
|
Eksperimentel: CHOP regimen
CHOP regimen(Cyclophosphamide,Vincristine,Epirubicin,Prednisone) : Cyclophosphamide 750mg/d,ivgtt, d1;Vincristine,1.4g/m2,ivgtt,
d1;Epirubicin,60mg/m2,ivgtt,d1;Prednisone 60mg/m2,po, d1-5
|
CHOP regimen(Cyclophosphamide,Vindesine,Epirubicin,Prednisone)
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
PFS
Tidsramme: up to end of follow-up-phase (approximately 24 months)
|
Progression-free survival
|
up to end of follow-up-phase (approximately 24 months)
|
RR
Tidsramme: every 6 weeks, up to completion of treatment (approximately 18 weeks)
|
Response Rate
|
every 6 weeks, up to completion of treatment (approximately 18 weeks)
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
OS
Tidsramme: up to the date of death (approximately 5 years)
|
Overall Survival
|
up to the date of death (approximately 5 years)
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Ledende efterforsker: Mingzhi Zhang, Pro,Dr, China, Henan Oncology Department of The First Affiliated Hospital of Zhengzhou University
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Forventet)
1. september 2018
Primær færdiggørelse (Forventet)
31. december 2019
Studieafslutning (Forventet)
31. december 2019
Datoer for studieregistrering
Først indsendt
12. august 2018
Først indsendt, der opfyldte QC-kriterier
12. august 2018
Først opslået (Faktiske)
15. august 2018
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
15. august 2018
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
12. august 2018
Sidst verificeret
1. august 2018
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
- Sygdomme i immunsystemet
- Neoplasmer efter histologisk type
- Neoplasmer
- Lymfoproliferative lidelser
- Lymfesygdomme
- Immunproliferative lidelser
- Lymfom, Non-Hodgkin
- Lymfom
- Lymfom, T-celle
- Lymfom, T-celle, perifert
- Molekylære mekanismer for farmakologisk virkning
- Enzymhæmmere
- Antineoplastiske midler
- Proteinkinasehæmmere
- Apatinib
Andre undersøgelses-id-numre
- hnslblzlzx2018-5
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ingen
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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