Diese Seite wurde automatisch übersetzt und die Genauigkeit der Übersetzung wird nicht garantiert. Bitte wende dich an die englische Version für einen Quelltext.

Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD)

15. März 2019 aktualisiert von: National Institutes of Health Clinical Center (CC)

Study of Zika Virus and Related Arbovirus Infections in Deferred Blood Donors

Background:

Zika virus is mostly passed on by the bite of an infected mosquito. It usually causes mild illness. But in pregnant women it can cause serious birth defects to the baby. The virus can also spread by blood transfusion and sexual intercourse. This is why the U.S. Food & Drug Administration (FDA) recommended that people should not give blood if possibly exposed to Zika virus. Dengue virus and chikungunya virus are passed by the same mosquitoes as Zika virus. These can cause severe reactions if passed through transfused blood.

Donated blood is usually not tested for these three viruses. Researchers want to count the infections in people who have been exposed because of travel or sexual exposure. They want to learn the risk these viruses might pose to the U.S. blood supply. They also want to study the natural history of these viruses by following infected people over time.

Objective:

To study the risk of Zika, dengue, and chikungunya viruses to the U.S. blood supply.

Eligibility:

Adults age 18 or older who were turned down for donating blood because of possible exposure to certain viruses.

Design:

Participants will have blood and urine tests. They will answer questions about their travel.

They will be called in about a week with virus test results.

Participants with negative results do not have any more study visits.

Participants with positive results will be asked to stay in the study for 6 months. They will have weekly clinic visits and tests until results are negative for 2 straight weeks. Once test results are negative, they will have monthly visits. Visits will include physical exams, blood and urine samples, and optional semen samples from men.

Most people will have 3-4 weekly visits and 5 monthly visits.

Studienübersicht

Status

Abgeschlossen

Bedingungen

Detaillierte Beschreibung

Zika virus (ZIKV) is an Aedes species mosquito-transmitted Flavivirus responsible for an ongoing epidemic in over twenty countries and territories in the Caribbean, and in North, Central and South America. A 20-fold increased risk of microcephaly has been reported in newborns of infected mothers in Brazil. Of nine identified pregnant travelers returning to the U.S. from areas with local ZIKV infection, five have experienced severe neonatal outcomes.

ZIKV can be transmitted via blood transfusion and by sexual exposure to a ZIKV-infected man. In response, AABB (formerly the American Association of Blood Banks) made recommendations and the Food and Drug Administration (FDA) issued guidance for donor deferral based on 1) travel to locations with active ZIKV transmission; or for 2) sexual exposure to a man who has traveled to an area with active ZIKV transmission. Further, Aedes species mosquito vectors that transmit ZIKV also transmit dengue virus (DENV) and chikungunya virus (CHIKV). Areas with local ZIKV transmission also commonly have local DENV and CHIKV transmission. DENV and CHIKV are transmissible via blood transfusion and can result in severe outcomes in transfusion recipients.

The primary aims of this study are to: 1) assess the prevalence of ZIKV, DENV and CHIKV infection (RNA-positives) among adults who attempted to donate blood but were deferred because of travel to places with local transmission of ZIKV, DENV and/or CHIKV (travel-deferred donors); 2) assess the prevalence of ZIKV infection (RNA-positives) among adults who attempted to donate blood who were deferred due to potential sexual exposure to ZIKV infection; 3) assess the prevalence of ZIKV, DENV and CHIKV infection (RNA-positives) among blood donors whose blood or platelets were collected and who called back to report any illness within 2 weeks of donation; and to 4) study the 24-week natural history of ZIKV, DENV and CHIKV infection among deferred adult donors who tested RNA-positive for any of these agents.

Studientyp

Beobachtungs

Einschreibung (Tatsächlich)

34

Kontakte und Standorte

Dieser Abschnitt enthält die Kontaktdaten derjenigen, die die Studie durchführen, und Informationen darüber, wo diese Studie durchgeführt wird.

Studienorte

  • Vereinigte Staaten
    • Maryland
      • Bethesda, Maryland, Vereinigte Staaten, 20892
        • National Institutes of Health Clinical Center

Teilnahmekriterien

Forscher suchen nach Personen, die einer bestimmten Beschreibung entsprechen, die als Auswahlkriterien bezeichnet werden. Einige Beispiele für diese Kriterien sind der allgemeine Gesundheitszustand einer Person oder frühere Behandlungen.

Zulassungskriterien

Studienberechtigtes Alter

18 Jahre und älter (Erwachsene, Älterer Erwachsener)

Akzeptiert gesunde Freiwillige

Nein

Studienberechtigte Geschlechter

Alle

Beschreibung

  • INCLUSION CRITERIA:
  • Adults who traveled within the past month to places with local transmission of ZIKV, DENV and/or CHIKV who would otherwise be eligible to donate blood;
  • Volunteer adult blood donors or potential blood donors who are deferred from blood donation because they tested positive for Zika virus.

  • Volunteer adult blood and platelet donors (blood donors) who present to the NIH Clinical Center Department of Transfusion Medicine (DTM) and the Fishers Lane Donor Center are eligible for study enrollment if they:

    1. Are deferred because of travel to an area with active ZIKV transmission within the past 4 weeks; or
    2. Are deferred because of sexual contact during the past 4 weeks with a sexual partner who traveled to an area with active ZIKV transmission in the 3 months prior to that instance of sexual contact; or
    3. Are deferred because of travel to a malaria-endemic area; and returned from the area in the past month; or
    4. Have donated blood or platelets AND within 2 weeks of donation they called the NIH DTM or Fishers Lane Donor Centers to report any signs or symptoms of infection, AND they traveled to an area with active transmission of ZIKV, DENV or CHIKV within the past 4 weeks (from symptom onset); OR had sexual contact within the past 4 weeks (from symptom onset) with a sexual partner who traveled to an area with active ZIKV transmission in the 3 months prior to that instance of sexual contact.

EXCLUSION CRITERIA:

Potential donors who do not meet the inclusion criteria are excluded. Potential donors under 18 years of age, paid or research blood donors and pregnant women are excluded from enrollment. Children are not eligible to donate blood without parental consent and the frequency of number of follow-up visits places an undue burden on school age children. Paid or research blood donors are not representative of the normal blood donor population. Pregnant women are not eligible to donate blood.

Studienplan

Dieser Abschnitt enthält Einzelheiten zum Studienplan, einschließlich des Studiendesigns und der Messung der Studieninhalte.

Wie ist die Studie aufgebaut?

Designdetails

Was misst die Studie?

Primäre Ergebnismessungen

Ergebnis Maßnahme
Zeitfenster
Prevalence of ZIKV, DENV and CHIKV infection (RNA-positives) among travel-deferred adult blood donors in the study population.
Zeitfenster: Time 0; among RNA-positives: weeks 1,2,3,4,5,6,7,8,9,10,11,12,16,20,24
Time 0; among RNA-positives: weeks 1,2,3,4,5,6,7,8,9,10,11,12,16,20,24
Prevalence of ZIKV infection (RNApositives) among adult blood donors with a history of potential sexual exposure to ZIKV infection, in the study population.
Zeitfenster: Time 0; among RNA-positives: weeks 1,2,3,4,5,6,7,8,9,10,11,12,16,20,24
Time 0; among RNA-positives: weeks 1,2,3,4,5,6,7,8,9,10,11,12,16,20,24
24-week Natural History of ZIKV, DENV and CHIKV (RNA-positives).
Zeitfenster: weeks 1,2,3,4,5,6,7,8,9,10,11,12,16,20,24
weeks 1,2,3,4,5,6,7,8,9,10,11,12,16,20,24

Mitarbeiter und Ermittler

Hier finden Sie Personen und Organisationen, die an dieser Studie beteiligt sind.

Sponsor

National Institutes of Health Clinical Center (CC)

Ermittler

  • Hauptermittler: Robert D Allison, M.D., National Institutes of Health Clinical Center (CC)

Publikationen und hilfreiche Links

Die Bereitstellung dieser Publikationen erfolgt freiwillig durch die für die Eingabe von Informationen über die Studie verantwortliche Person. Diese können sich auf alles beziehen, was mit dem Studium zu tun hat.

Allgemeine Veröffentlichungen

Studienaufzeichnungsdaten

Diese Daten verfolgen den Fortschritt der Übermittlung von Studienaufzeichnungen und zusammenfassenden Ergebnissen an ClinicalTrials.gov. Studienaufzeichnungen und gemeldete Ergebnisse werden von der National Library of Medicine (NLM) überprüft, um sicherzustellen, dass sie bestimmten Qualitätskontrollstandards entsprechen, bevor sie auf der öffentlichen Website veröffentlicht werden.

Haupttermine studieren

Studienbeginn

8. Juni 2016

Primärer Abschluss (Tatsächlich)

14. März 2019

Studienabschluss (Tatsächlich)

14. März 2019

Studienanmeldedaten

Zuerst eingereicht

8. Juni 2016

Zuerst eingereicht, das die QC-Kriterien erfüllt hat

8. Juni 2016

Zuerst gepostet (Schätzen)

9. Juni 2016

Studienaufzeichnungsaktualisierungen

Letztes Update gepostet (Tatsächlich)

18. März 2019

Letztes eingereichtes Update, das die QC-Kriterien erfüllt

15. März 2019

Zuletzt verifiziert

14. März 2019

Mehr Informationen

Begriffe im Zusammenhang mit dieser Studie

Schlüsselwörter

Zusätzliche relevante MeSH-Bedingungen

Andere Studien-ID-Nummern

  • 160124
  • 16-CC-0124

Diese Informationen wurden ohne Änderungen direkt von der Website clinicaltrials.gov abgerufen. Wenn Sie Ihre Studiendaten ändern, entfernen oder aktualisieren möchten, wenden Sie sich bitte an register@clinicaltrials.gov. Sobald eine Änderung auf clinicaltrials.gov implementiert wird, wird diese automatisch auch auf unserer Website aktualisiert .

Klinische Studien zur Dengue-Virus

Suchen Sie nach ähnlichen Studien

Sponsoren und Mitarbeiter

Krankheiten

Drogeninterventionen

CROs by country

CROs in Saudi Arabia

Bedingungen

Seltene Krankheiten

Drogeninterventionen

Nahrungsergänzungsmittel

Sponsor / Mitarbeiter

Standorte

3
Abonnieren