- ICH GCP
- Registro de ensayos clínicos de EE. UU.
- Ensayo clínico NCT03289793
NEUROFEEDBACK on Event-Related Potential (ERP) (MyB)
Clinical Evaluation of a Brain Computer Interfaces (BCI)-Based Training of Attention in Children With Attention Deficit Hyperactivity Disorder (ADHD)
This project aims to assess the evolution of symptoms in ADHD children from 8 to 17 years, with various types of attention training.
Different groups A, B and C will be evaluated: the first with Neurofeedback training, the second with a similar training but not indexed on brain activity and the third without training.
30 patients will be randomly assigned to groups A and B according to a ratio 2:1.
Others patients who meet the same criteria but for logistical reasons cannot comply with the training constraints will be assigned to group C.
Children included in groups A and B will participate in training sessions (Neurofeedback and control training, respectively) as well as in four evaluation sessions. Children in group C will only participate in evaluation sessions (baseline control group).
Patients of groups A and B will be followed over 6 months: 4 months of training and a follow-up evaluation 2 months after training.
Patients of group C will be followed each 2 months for 6 months. This study uses electro-encephalography measures, serious video game, neuropsychological tests and questionnaires.
It also uses actigraphy measures to evaluate sleep quality.
Descripción general del estudio
Estado
Intervención / Tratamiento
Tipo de estudio
Inscripción (Actual)
Fase
- No aplica
Contactos y Ubicaciones
Ubicaciones de estudio
-
-
-
Bron, Francia, 69500
- Hospices Civils de Lyon
-
-
Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Descripción
Inclusion Criteria:
- Children and teenagers aged from 8 to 17 years' old
- Children and teenagers with a deficit attention disorder with or without hyperactivity, in the mixed form or in a pure inattentive form according to Diagnostique et Statistique des troubles Mentaux (DSM)-V.
- Children and teenagers having a score in Verbal Comprehension Index (or Index Verbal Reasoning) and Perceptual Reasoning Index (or Index Reasoning fluid) ≥ 80 of WISC IV or V test, not older than two years.
- Children and teenagers without psychostimulant treatment
- Children and teenagers with psychostimulant treatment agreed to achieve a therapeutic break at each visit day and with a stable dose during all the study.
- Children and teenagers whose parents have agreed and signed informed consent form of the study.
Exclusion Criteria:
- Children aged less than 8 and teenagers are more than 18 years' old.
- Children and teenagers having a score in Verbal Comprehension Index (or Index Verbal Reasoning) and Perceptual Reasoning Index (or Index Reasoning fluid) < 80 of WISC IV or V test, not older than two years.
- Children and teenagers with developmental disorder except "Dys" disorders.
- Children and teenagers with pure hyperactivity (without attentional deficit)
- Children and teenagers with epilepsy except benign epilepsies (without brain damage), free of crisis for two years and without treatment.
- Children and teenagers with ADHD with conduct disorders and aggression
- Children and teenagers with ADHD and Tourette's syndrome.
- Patients treated by anti / epilepsy or psychotropic treatments (with the exception of psychostimulant treatment).
- Patients with psychostimulant treatment and whose parents aren't agreed to achieve a therapeutic break at each visit day.
- Patients with visual deficiency uncorrectable with lenses or glasses.
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Investigación de servicios de salud
- Asignación: Aleatorizado
- Modelo Intervencionista: Asignación paralela
- Enmascaramiento: Triple
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
---|---|
Experimental: Group A
Children will be assigned to this group in a random fashion according to a ratio 2:1 with respect to group B (see below). 20 subjects will be included in this group. |
Children in group A will receive BCI-based training implemented through original P300-based controlled games. They will attend 30 1-hour long training sessions at a pace of 2 sessions per week. Each session includes: installation of the child, the EEG system and an eye-tracking system, a 5-minutes relaxation phase, a short EEG recording at rest, a brief reminder of the instructions, 30 minutes of training by playing video games and finally a time for the child to wash her/his hair. Moreover, 4 neuropsychological sessions will complement the 30 training sessions. During these sessions neuropsychological tests and quality of life questionnaires will be answered. |
Comparador activo: Group B
Children will be assigned in this group in a random fashion.
10 subjects will be included in this group.
|
Children in group B will receive a training that is not based on brain activity, but in a blind fashion. They will attend 30 1-hour long training sessions at a pace of 2 sessions per week. Each session includes: installation of the child, setting up the EEG and eye-tracking systems, a 5-minutes relaxation phase, short EEG recording at rest, a brief reminder of the instructions, 30 minutes of video game based training and finally a time for the child to wash her/his hair. Besides, 4 neuropsychological sessions will complement the 30 training sessions. During these sessions neuropsychological tests and quality of life questionnaires will be performed. |
Comparador activo: Group C
Will be included in this group children who meet the inclusion criteria and who, with their families, are motivated to participate in the study but cannot claim to be part of groups A or B (because of logistical constraints: living too far away to comply with the frequency of the visits required by the training). Group C allows to follow the natural evolution of children with ADHD with no intervention. |
The children included in this group will not receive any training.
They only take part to the 4 neuropsychological sessions.
Like others, they will attend 1 neuropsychological session every two months over six months.
|
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
---|---|---|
Evaluation of the relative effect on symptoms of inattention between the two proposed training techniques, A and B, with the ADHD Rating Scale in children with ADHD
Periodo de tiempo: every two months over six months.
|
Questions with odd numbers interested in the dimension "inattentive" will particularly be studied.
The investigator expect an improvement in the type of score: ''ADHD-Inattentive'' children in group A compared to children in Group B. More specifically, he expect to improve responses to questions number 1,3,5,7,9,11,13,15 and 17.
By definition, an evolving response would be to move from " 2=Often; 3=Very often" to " 1=Sometimes; 0=Rarely/Never".
|
every two months over six months.
|
Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
---|---|---|
Neuropsychological assessments of effects of training on the symptoms of inattention in ADHD children
Periodo de tiempo: every months over six months.
|
ADHD Rating Scale (questions with odd numbers) will be performed ADHD children from groups A, B and C will be compared
|
every months over six months.
|
Neuropsychological assessments of effects of training on the symptoms of inattention in ADHD children
Periodo de tiempo: every months over six months.
|
Bron/Lyon Attention Stability test (BLAST) test will be performed ADHD children from groups A, B and C will be compared
|
every months over six months.
|
Neuropsychological assessments of effects of training on the symptoms of inattention in ADHD children
Periodo de tiempo: every months over six months.
|
Wechsler Intelligence Scale for Children (WISC) subtests will be performed ADHD children from groups A, B and C will be compared
|
every months over six months.
|
Neuropsychological assessments of the effects of the lack of training on the symptoms of inattention in ADHD children
Periodo de tiempo: every months over six months.
|
Wechsler Intelligence Scale for Children (WISC) will be performed ADHD children from groups A, B and C will be compared
|
every months over six months.
|
Neuropsychological assessments of the effects of the lack of training on the symptoms of inattention in ADHD children
Periodo de tiempo: every months over six months.
|
ADHD Rating Scale (questions with odd numbers) will be performed ADHD children from groups A, B and C will be compared
|
every months over six months.
|
Neuropsychological assessments of the effects of the lack of training on the symptoms of inattention in ADHD children
Periodo de tiempo: every months over six months.
|
Bron/Lyon Attention Stability test (BLAST) will be performed ADHD children from groups A, B and C will be compared
|
every months over six months.
|
Compare the effects of the two types of trainings on the hyperactivity symptoms in ADHD children using neuropsychological assessments.
Periodo de tiempo: every two months over six months
|
ADHD Rating Scale (questions with even numbers), Test d'évaluation de l'Attention (TAP) and Continuous Performance Test (CPT) will be performed ADHD children from groups A, B and C will be compared
|
every two months over six months
|
neuropsychological assessments of the effects of the two types of trainings on the hyperactivity symptoms in ADHD children
Periodo de tiempo: every two months over six months
|
ADHD Rating Scale (questions with even numbers) will be performed ADHD children from groups A, B and C will be compared
|
every two months over six months
|
neuropsychological assessments of the effects of the two types of trainings on the hyperactivity symptoms in ADHD children
Periodo de tiempo: every two months over six months
|
Test d'évaluation de l'Attention (TAP) will be performed ADHD children from groups A, B and C will be compared
|
every two months over six months
|
neuropsychological assessments of the effects of the two types of trainings on the hyperactivity symptoms in ADHD children
Periodo de tiempo: every two months over six months
|
Continuous Performance Test (CPT) will be performed ADHD children from groups A, B and C will be compared
|
every two months over six months
|
neuropsychological assessments of the effects of the lack of training on the impulsivity symptoms in ADHD children
Periodo de tiempo: every two months over six months
|
Continuous Performance Test (CPT) will be performed ADHD children from groups A, B and C will be compared
|
every two months over six months
|
neuropsychological assessments of the effects of the lack of training on the impulsivity symptoms in ADHD children
Periodo de tiempo: every two months over six months
|
Test d'évaluation de l'Attention (TAP) will be performed ADHD children from groups A, B and C will be compared
|
every two months over six months
|
neuropsychological assessments of the effects of the lack of training on the impulsivity symptoms in ADHD children
Periodo de tiempo: every two months over six months
|
ADHD Rating Scale (questions with even numbers) will be performed ADHD children from groups A, B and C will be compared
|
every two months over six months
|
neuropsychological assessments of the effects of the lack of training on the hyperactivity symptoms in ADHD children
Periodo de tiempo: every two months over six months
|
Continuous Performance Test (CPT) will be performed ADHD children from groups A, B and C will be compared
|
every two months over six months
|
neuropsychological assessments of the effects of the lack of training on the hyperactivity symptoms in ADHD children
Periodo de tiempo: every two months over six months
|
ADHD Rating Scale (questions with even numbers) will be performed ADHD children from groups A, B and C will be compared
|
every two months over six months
|
neuropsychological assessments of the effects of the lack of training on the hyperactivity symptoms in ADHD children
Periodo de tiempo: every two months over six months
|
Test d'évaluation de l'Attention (TAP) will be performed ADHD children from groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups A (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
ADHD Rating Scale (questions with odd numbers) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups A (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
TAP will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups A (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
CPT will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups A (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
BLAST will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups A (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
Attention and Distractibility Questionnaire (for children) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups B (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
ADHD Rating Scale (questions with odd numbers)will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups B (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
TAP will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups B (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
CPT will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups B (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
BLAST will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups B (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
Attention and Distractibility Questionnaire (for children) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups C (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
ADHD Rating Scale (questions with odd numbers) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups C (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
TAP will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups C (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
CPT will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups C (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
BLAST will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify whether the changes in inattentive symptoms in groups C (Neurofeedback training) correlate with changes in specific EEG parameter, namely the P300 wave.
Periodo de tiempo: every two months over six months
|
Attention and Distractibility Questionnaire (for children) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify the evolution of the classical Neurofeedback biomarkers Slow Cortical Potential (SCP))
Periodo de tiempo: every two months over six months
|
ADHD Rating Scale (questions with odd numbers) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify the evolution of the classical Neurofeedback biomarkers Slow Cortical Potential (SCP))
Periodo de tiempo: every two months over six months
|
TAP will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify the evolution of the classical Neurofeedback biomarkers Slow Cortical Potential (SCP))
Periodo de tiempo: every two months over six months
|
BLAST will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify the evolution of the classical Neurofeedback biomarkers Slow Cortical Potential (SCP))
Periodo de tiempo: every two months over six months
|
Attention and Distractibility Questionnaire (child) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Assess whether the classical Neurofeedback biomarkers correlate with the evolution of behavioral and primary neurophysiological measures (P300) in all groups.
Periodo de tiempo: every two months over six months
|
ADHD Rating Scale (questions with odd numbers) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Assess whether the classical Neurofeedback biomarkers correlate with the evolution of behavioral and primary neurophysiological measures (P300) in all groups.
Periodo de tiempo: every two months over six months
|
TAP will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Assess whether the classical Neurofeedback biomarkers correlate with the evolution of behavioral and primary neurophysiological measures (P300) in all groups.
Periodo de tiempo: every two months over six months
|
BLAST will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Assess whether the classical Neurofeedback biomarkers correlate with the evolution of behavioral and primary neurophysiological measures (P300) in all groups.
Periodo de tiempo: every two months over six months
|
Attention and Distractibility Questionnaire (child) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify the evolution of the classical Neurofeedback biomarkers Theta/Beta Ratio (TBR)
Periodo de tiempo: every two months over six months
|
ADHD Rating Scale (questions with odd numbers) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify the evolution of the classical Neurofeedback biomarkers Theta/Beta Ratio (TBR)
Periodo de tiempo: every two months over six months
|
TAP will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify the evolution of the classical Neurofeedback biomarkers Theta/Beta Ratio (TBR)
Periodo de tiempo: every two months over six months
|
BLAST will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify the evolution of the classical Neurofeedback biomarkers Theta/Beta Ratio (TBR)
Periodo de tiempo: every two months over six months
|
Attention and Distractibility Questionnaire (child) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Assess whether the classical Neurofeedback biomarkers TBR correlate with the evolution of behavioral and primary neurophysiological measures (P300) in all groups.
Periodo de tiempo: every two months over six months
|
ADHD Rating Scale (questions with odd numbers) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Assess whether the classical Neurofeedback biomarkers TBR correlate with the evolution of behavioral and primary neurophysiological measures (P300) in all groups.
Periodo de tiempo: every two months over six months
|
TAP will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Assess whether the classical Neurofeedback biomarkers TBR correlate with the evolution of behavioral and primary neurophysiological measures (P300) in all groups.
Periodo de tiempo: every two months over six months
|
BLAST will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Assess whether the classical Neurofeedback biomarkers TBR correlate with the evolution of behavioral and primary neurophysiological measures (P300) in all groups.
Periodo de tiempo: every two months over six months
|
Attention and Distractibility Questionnaire (child) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify the evolution of the classical Neurofeedback biomarkers Sensori-Moteur Rythm (SMR)
Periodo de tiempo: every two months over six months
|
ADHD Rating Scale (questions with odd numbers) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify the evolution of the classical Neurofeedback biomarkers Sensori-Moteur Rythm (SMR)
Periodo de tiempo: every two months over six months
|
TAP will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify the evolution of the classical Neurofeedback biomarkers Sensori-Moteur Rythm (SMR)
Periodo de tiempo: every two months over six months
|
BLAST will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Quantify the evolution of the classical Neurofeedback biomarkers Sensori-Moteur Rythm (SMR)
Periodo de tiempo: every two months over six months
|
Attention and Distractibility Questionnaire (child) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Assess whether the Neurofeedback biomarkers SMR correlate with the evolution of behavioral and primary neurophysiological measures (P300) in all groups.
Periodo de tiempo: every two months over six months
|
ADHD Rating Scale (questions with odd numbers)will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Assess whether the Neurofeedback biomarkers SMR correlate with the evolution of behavioral and primary neurophysiological measures (P300) in all groups.
Periodo de tiempo: every two months over six months
|
TAP will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Assess whether the Neurofeedback biomarkers SMR correlate with the evolution of behavioral and primary neurophysiological measures (P300) in all groups.
Periodo de tiempo: every two months over six months
|
BLAST will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Assess whether the Neurofeedback biomarkers SMR correlate with the evolution of behavioral and primary neurophysiological measures (P300) in all groups.
Periodo de tiempo: every two months over six months
|
Attention and Distractibility Questionnaire (child) will be evaluated ADHD children of groups A, B and C will be compared
|
every two months over six months
|
Evaluate the impact of the trainings on the sleep quality in ADHD children.
Periodo de tiempo: every two months over six months.
|
Sleep questionnaires will be distributed ADHD children in groups A, B and C will be compared.
|
every two months over six months.
|
Evaluate the impact of the trainings on the sleep quality in ADHD children.
Periodo de tiempo: every two months over six months.
|
The sleep data may also be collected using an actigraph (ancillary study).
ADHD children in groups A, B and C will be compared.
|
every two months over six months.
|
Evaluating the impact of the trainings on the quality of life in ADHD children.
Periodo de tiempo: every two months over six months
|
The Child Behavior CheckList (CBCL) questionnaire will be performed Groups A, B and C will be compared. |
every two months over six months
|
Evaluating the impact of the trainings on the quality of life in ADHD children.
Periodo de tiempo: every two months over six months
|
Information about the quality of life will be also collected in a logbook by family members and provided at each visit. Groups A, B and C will be compared. |
every two months over six months
|
Colaboradores e Investigadores
Patrocinador
Investigadores
- Investigador principal: Alexis ARZIMANOGLOU, Hospices Civils de Lyon
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio (Actual)
Finalización primaria (Actual)
Finalización del estudio (Actual)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- 69HCL15_0214
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .
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