A Pharmacokinetic Evaluation Study in Healthy Volunteers

Inclusion Criteria:

• Are current nonsmokers or previous smokers who have not smoked within 6 months and who do not have greater than or equal to a 10 pack-year history of tobacco use
• Are within 20% of their ideal body weight
• Are healthy on the basis of a pre-trial physical examination

Exclusion Criteria:

• History or suspicion of recent alcohol, barbiturate, amphetamine or narcotic abuse or a positive urine drug test at study screening
• History of cardiac arrhythmias, any pathological abnormality on the ECG, bronchospasm, diabetes mellitus, thyrotoxicosis, Parkinsonism, asthma, COPD or cardiovascular disease significant drug allergy
• Subject with a physical obstruction in the nose
• Use of concomitant medication other than hormonal contraceptives and multi-vitamins
• Subjects with a current upper respiratory illness or infection for the 2 weeks prior to screening or any chronic respiratory illness