- ICH GCP
- Registro degli studi clinici negli Stati Uniti
- Sperimentazione clinica NCT02409485
Improving Self-Management in Head and Neck Cancer
14 gennaio 2020 aggiornato da: Hoda Badr, Baylor College of Medicine
By teaching skills to improve the coordination of care and support in couples coping with head and neck cancer (HNC), this couple-based psychosocial intervention holds great promise for improving self-management, reducing costly hospitalizations and treatment interruptions, and improving both partners' quality of life.
Home-based delivery will enhance future dissemination and outreach to those who do not have access to psychosocial services or live far away from their care centers.
If found effective, the intervention may also have salutary downstream effects on the health and well-being of HNC patients and their partners.
Panoramica dello studio
Stato
Completato
Condizioni
Intervento / Trattamento
Descrizione dettagliata
Patients treated with radiation (XRT) for head and neck cancers (HNCs) experience significant side effects such as abnormally reduced salivation, difficulty swallowing, and taste changes even after they have been definitively treated.
To control side effects and minimize discomfort, intensive self-care protocols are prescribed, but adherence is poor.
Partners (spouses/significant others) can play a critical role in supporting adherence, but often lack knowledge, experience high rates of distress, and display poor communication (e.g., critical or controlling), that can interfere with patient self-care.
The investigators have developed a home-based couples skills-training (CST) intervention that teaches: 1) self-management skills to control/prevent side-effects; 2) communication skills to facilitate coordination of care and support; and 3) strategies to improve communal coping and confidence in the ability to work as a team.
The goal is to reduce healthcare utilization and improve multiple domains of patient and partner QOL.
Specific aims are to: develop and evaluate the content and materials of the CST intervention (AIM 1) and evaluate its feasibility and acceptability (AIM 2).
The multidisciplinary team will review and evaluate the content we have already developed based on the ongoing work with HNC couples (K07).
Once content is finalized, tailored manuals will be developed for patients and partners and evaluated through two focus groups (AIM 1).
The investigators expect that most couples (> 60%) approached will agree to participate and that CST will be well-accepted (AIM 2).
Knowledge gained will be used to refine CST and to collect data on effect sizes and variation for a larger trial.
Innovation: CST takes a multiple-behavioral approach to addressing and preventing HNC treatment side effects and, in the process, seeks to improve multiple domains of QOL.
It is also the first program in HNC that actively involves both members of the couple to address barriers in the home environment in which self-management occurs.
Finally, this study conceptualizes the couple relationship as a resource and leverages that resource to improve patient care and outcomes.
Impact: Home-based delivery will enhance future dissemination and outreach to the target population.
Overall, CST holds great promise for improving patient self-management behaviors, reducing costly hospitalizations and treatment interruptions, and improving multiple aspects of patient and partner QOL.
Tipo di studio
Interventistico
Iscrizione (Effettivo)
60
Fase
- Non applicabile
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Luoghi di studio
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Texas
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Houston, Texas, Stati Uniti, 77030
- Baylor College of Medicine
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Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
18 anni e precedenti (Adulto, Adulto più anziano)
Accetta volontari sani
No
Sessi ammissibili allo studio
Tutto
Descrizione
Inclusion Criteria:
- patient is initiating radiotherapy for HNC
- patient has Karnofsky score > 50 (ambulatory & capable of self-care)
- patient lives with a partner (spouse/significant other - includes homo- and heterosexual couples)
- patient/partner is able to provide informed consent
- patient/partner is > age 18.
Exclusion Criteria:
- patient has significant comorbidities (e.g., HIV, transplant), or another illness that may require hospitalization
- patient/partner cannot read or communicate using spoken English.
- individuals with diminished mental capacity
- prisoners
- pregnant women
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Terapia di supporto
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione parallela
- Mascheramento: Nessuno (etichetta aperta)
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
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Sperimentale: Couples Skill-Training (CST)
CST provides education about acute and long-term side-effects of HNC and teaches: 1) self-management skills to control/prevent side-effects; 2) communication skills to facilitate coordination of care; and, 3) strategies to improve communal coping and confidence in the ability to work as a team.
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Patients and partners each receive a workbook and 6 one-hour telephone sessions with a Masters level trained interventionist.
Manual content is tailored based on role (patient or partner).
Couples participate together via speaker phone for half the sessions and patients and partners receive separate (individual) intervention calls for the other half of the sessions.
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Nessun intervento: Usual Medical Care (UMC)
Patients receive standard symptom management education by their health care team.
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Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
---|---|---|
Feasibility of the CST intervention as assessed by recruitment and retention rates
Lasso di tempo: 6 months
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recruitment and retention rates
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6 months
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Acceptability of the CST intervention as assessed by the program evaluation questionnaire
Lasso di tempo: 6 months
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satisfaction with the intervention by completing a program evaluation questionnaire developed by the study team that asks about perceived skills mastery and satisfaction with program content and logistics
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6 months
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Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
---|---|---|
PROMIS short form anxiety and depression
Lasso di tempo: 6 months
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measures distress with Patient Reported Outcomes Measurement Information System (PROMIS) short form for anxiety and depression
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6 months
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Patient QOL measured by MD Anderson Symptom Inventory - Head and Neck (MDASI-HN)
Lasso di tempo: 6 months
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measures QOL for patients
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6 months
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Partners QOL measured by Short Form 12 (SF12)
Lasso di tempo: 6 months
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measures QOL for partners
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6 months
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Short Form Dyadic Adjustment Scale (DAS7)
Lasso di tempo: 6 months
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measures Relationship functioning
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6 months
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Healthcare utilization as assessed by number of hospitalizations and unplanned clinic visits
Lasso di tempo: 6 months
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number of hospitalizations and unplanned clinic visits
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6 months
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Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Collaboratori
Investigatori
- Investigatore principale: Hoda Badr, PhD, Icahn School of Medicine at Mount Sinai
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio (Effettivo)
1 novembre 2014
Completamento primario (Effettivo)
1 ottobre 2018
Completamento dello studio (Effettivo)
1 aprile 2019
Date di iscrizione allo studio
Primo inviato
1 aprile 2015
Primo inviato che soddisfa i criteri di controllo qualità
3 aprile 2015
Primo Inserito (Stima)
6 aprile 2015
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
18 gennaio 2020
Ultimo aggiornamento inviato che soddisfa i criteri QC
14 gennaio 2020
Ultimo verificato
1 gennaio 2020
Maggiori informazioni
Termini relativi a questo studio
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- GCO 12-1641
- R21CA178478 (Sovvenzione/contratto NIH degli Stati Uniti)
- H-48778 (Altro identificatore: Baylor College of Medicine)
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .
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