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Piloting MOL Intervention for Neuroleptic Decision Making

18 maggio 2019 aggiornato da: Rea Dicks, University of Manchester

A Pilot Study to Assess the Feasibility and Acceptability of a Novel Intervention to Help People Think About Their Neuroleptic Medication Use.

The aim of the current study is to pilot a novel intervention to help people explore their decision making around the use of neuroleptic medication. A case series design will be used, with outcome variables measured at multiple time points pre-, during- and post-intervention. Participants will also be asked to complete an evaluation interview post-intervention. The primary aim is to investigate the feasibility and acceptability of offering the intervention.

Panoramica dello studio

Stato

Completato

Intervento / Trattamento

Descrizione dettagliata

Many service users experiencing psychosis are prescribed neuroleptic medication as the core component of treatment. However, discontinuations rates are high, which may be influenced by poor response rates and scepticism about the value of medication.

Frequently people discontinue without professional involvement, which is associated with negative outcomes. It is a particularly high risk period for relapse, especially if withdrawal is done quickly. There is an urgent need to advance practices in helping service-users to make a decision regarding neuroleptic medication that can then be supported by clinicians.

Current interventions regarding medication use predominantly focus on increasing adherence to medication regimes using, for example, financial incentives. This raises ethical concerns over the potential for service users' priorities and preferences to be disregarded, leading to increased coercion and reduced empowerment for service users. The recovery movement emphasises the need to understand personal priorities when considering treatment options and informed choice and shared-decision making is promoted by government initiatives and practice guidelines.

Shared decision-making commonly occurs within physical health settings. Patient decision aids have been found to improve patients' knowledge of available options and help patients to have more accurate expectations of potential benefits and harms, reach choices that are more consistent with personal values and participate in decision making. Despite this, shared-decision making has not been adopted more widely and is particularly poor within mental health settings.

The current study aims to explore the feasibility and acceptability of an intervention aimed at helping service users in mental health services think about their own personal priorities and decision-making around medication use. Current psychological interventions, such as cognitive behavioural therapy (CBT) and motivational interviewing (MI), view decision-making in terms of individuals making cost-benefit analyses, which then informs their "planned" behaviour. Such interventions thus target the identification of desirable medication related behaviours and then help the individual to make those behaviours occur.

Perceptual Control Theory (PCT) offers an alternative framework in which to understand medication related decision-making and behaviour. PCT regards all behaviour as goal directed but states that individuals control their experiences (or input) not their behaviour (or output). From this perspective, behaviour is understood as a means by which an individual resolves discrepancies between how they currently experience something (a current perception) and the way they want that experience to be. There is recognition that people are usually unaware of many of the different priorities (or goals) they hold, although these priorities/ goals are often incompatible (in conflict). An intervention informed by PCT (Method of Levels; MOL) would, therefore, target increasing an individual's awareness of the different personal priorities/ goals they hold in relation to medication use. The intervention would focus on exploring conflict between personal priorities, as from a PCT perspective; conflict is what causes ambivalence or difficulties in being able to enact certain planned behaviours. The aim in the current study would be to use MOL to help people develop their awareness of what is important to them in relation to medication use, as opposed to focusing on planning specific behaviours.

The aim in the current study would be to use MOL to help people explore their decision around the use of neuroleptic medication. Traditionally the focus of a MOL session is determined by the client and can vary from person to person, however, for this study the sessions will be specifically focused on neuroleptic medication use. The sessions will aim to help people explore a range of thoughts and feelings about decisions around medication use and how these relate to other important life values and goals. Another key aim of sessions will be to help people develop awareness of conflicts in their goals so that they might begin to find potential resolution. Due to the nature of the intervention being very patient-led and idiosyncratic, the outcome will vary from person to person. The intervention does not attempt to increase adherence or encourage discontinuation to the neuroleptic medication. It aims to help people develop awareness of how they feel about using neuroleptic medication and how medication might relate to other things that are important to them in life.

If this is a feasible and acceptable approach to use then future research would explore whether prescribers could incorporate this approach to working in their consultations with service users.

Tipo di studio

Interventistico

Iscrizione (Effettivo)

5

Fase

  • Non applicabile

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Luoghi di studio

      • Manchester, Regno Unito
        • Greater Manchester Mental Health NHS Foundation Trust
    • Lancashire
      • Preston, Lancashire, Regno Unito, BB10 4el
        • Lancashire Care NHS Foundation Trust

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

16 anni e precedenti (Bambino, Adulto, Adulto più anziano)

Accetta volontari sani

No

Sessi ammissibili allo studio

Tutto

Descrizione

Inclusion Criteria:

  • Over 16 years of age
  • Capacity to provide informed written consent
  • Able to converse in English proficiently
  • Currently under the care of an Early Intervention Service or Community Mental Health Team
  • Ambivalent around medication use
  • Experience of psychosis
  • Be able to be assessed in an outpatient facility (exceptions will be made for disabilities)

Exclusion Criteria:

  • If currently experiencing such a deterioration in mental state that they may have difficulties making decisions in their life
  • If significant risk of harm to self or others is present
  • If there is an organic basis for psychosis

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Scopo principale: Altro
  • Assegnazione: N / A
  • Modello interventistico: Assegnazione di gruppo singolo
  • Mascheramento: Nessuno (etichetta aperta)

Armi e interventi

Gruppo di partecipanti / Arm
Intervento / Trattamento
Altro: Method of Levels
Talking therapy- duration and frequency of sessions to be determined by participant
Talking Therapy

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Number of participants recruited to the study
Lasso di tempo: through study completion, an average of 5 months.
Number of participants recruited to the study
through study completion, an average of 5 months.
Number of participants retained during the study
Lasso di tempo: through study completion, an average of 5 months.
Number of participants retained during the study
through study completion, an average of 5 months.
Change in therapeutic alliance from baseline to 12 weeks
Lasso di tempo: baseline, 12 weeks.
The Session Rating Scale is a brief therapeutic alliance measure designed for every session clinical use. The SRS is a four-item visual analogue instrument that explores the relationship, goals and topics, approach or method, and how the client perceives the session in total. Scores range between 0 and 40, higher scores suggest better therapeutic alliance.
baseline, 12 weeks.

Misure di risultato secondarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Change in treatment-related empowerment from baseline to 12 weeks
Lasso di tempo: baseline, 12 weeks.
The Treatment-related Empowerment Scale assesses the patients perceived degree of involvement within their treatment by assessing components of communication, treatment choice, decisions and satisfaction. The scale consists of 10 items in which respondents rate the extent to which their experience matches each statement on a 5 point Likert scale. High scores represent higher treatment-related empowerment.
baseline, 12 weeks.
Change in attitude towards medication from baseline to 12 weeks
Lasso di tempo: baseline, 12 weeks.
The Drug Attitude Inventory-10 a 10-item modified version of the Drug Attitude Inventory-30 Questionnaire, commonly used to evaluate medication adherence and captures an individual's general attitude about taking medication. Scores range between -10 and +10, higher scores indicate a more positive attitude towards medication.
baseline, 12 weeks.
Change in compliance to medication regime from baseline to 12 weeks
Lasso di tempo: baseline, 12 weeks.
Participants will be asked to rate their current compliance using a 4-point scale that was developed for another study (Barrowclough et al., 1999). Scores range from 0-4, higher scores indicate higher compliance.
baseline, 12 weeks.
Change in personal recovery from baseline to 12 weeks
Lasso di tempo: baseline, 12 weeks.
Questionnaire about the Process of Recovery a 15-item measure used to assess personal recovery. Scores range between 15 and 75, higher scores are indicative of recovery.
baseline, 12 weeks.
Change in engagement with services from baseline to 12 weeks
Lasso di tempo: baseline, 12 weeks.
The Service Engagement Scale is a 14-item clinician-rated measure that assesses service user engagement with community mental health services. Scores range between 0 and 42, lower scores indicate better engagement.
baseline, 12 weeks.

Collaboratori e investigatori

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Pubblicazioni e link utili

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Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio (Effettivo)

27 giugno 2018

Completamento primario (Effettivo)

23 marzo 2019

Completamento dello studio (Effettivo)

10 maggio 2019

Date di iscrizione allo studio

Primo inviato

18 aprile 2018

Primo inviato che soddisfa i criteri di controllo qualità

14 maggio 2018

Primo Inserito (Effettivo)

25 maggio 2018

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

21 maggio 2019

Ultimo aggiornamento inviato che soddisfa i criteri QC

18 maggio 2019

Ultimo verificato

1 maggio 2019

Maggiori informazioni

Termini relativi a questo studio

Altri numeri di identificazione dello studio

  • 238098

Piano per i dati dei singoli partecipanti (IPD)

Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?

Descrizione del piano IPD

Annoymous data files for outcome data will be shared on request

Periodo di condivisione IPD

Data will be available within 6 months of study completion

Criteri di accesso alla condivisione IPD

Data access requests will be reviewed by research team. Requestors will be required to sign a data access agreement

Tipo di informazioni di supporto alla condivisione IPD

  • STUDIO_PROTOCOLLO
  • ICF
  • RSI

Informazioni su farmaci e dispositivi, documenti di studio

Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti

No

Studia un dispositivo regolamentato dalla FDA degli Stati Uniti

No

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .

Prove cliniche su Method of Levels

3
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