Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
調査の概要
詳細な説明
The commonly used pain relievers acetaminophen and ibuprofen may impair musculoskeletal adaptations to progressive resistance exercise training by inhibiting exercise-induced muscle protein synthesis.
To test the hypothesis that acetaminophen and ibuprofen would diminish training-induced increases in fat-free mass, untrained men (n=26) aged ≥ 50 years participated in 16 weeks of high-intensity progressive resistance exercise training and bone-loading exercises and were randomly assigned to take ACET (1000 mg), ibuprofen (400 mg) or placebo 2 hours before each exercise session.
The primary outcome was the change in total body fat-free mass measured by dual-energy X-ray absorptiometry (DXA) at baseline and week 16. Our primary interest was in the comparison of the acetaminophen and placebo groups.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
-
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Colorado
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Aurora、Colorado、アメリカ、80045
- University of Colorado Denver
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- average use of acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) [including aspirin] less than 3 days per month
- not currently engaged in moderate-to-vigorous weight-lifting exercise
- non-smoker
- willing to participate in a supervised exercise program for 9 months
Exclusion Criteria:
- relative or absolute contraindications to regular use of acetaminophen or NSAIDs including known allergy or intolerance to either drug,history of peptic ulcer or GI bleeding, anemia, asthma with bronchospasm induced by aspirin or other NSAIDS, moderate or severe renal impairment, known hepatobiliary disease
- contraindications to exercise testing and training including congestive heart failure class III or IV, uncontrolled hypertension and unstable cardiovascular disease
- thyroid dysfunction
- orthopedic problems that limit the ability to perform vigorous exercise or increase the likelihood of the use of pain medications
- drugs known to alter bone metabolism
- allergy to lidocaine
- diabetes mellitus requiring pharmacologic therapy
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：トリプル
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
プラセボコンパレーター：プラセボ
|
high intensity progressive resistance exercise training
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実験的：Resistance training with Acetaminophen
Acetaminophen
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high intensity progressive resistance exercise training
|
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実験的：Resistance Training with ibuprofen
Ibuprofen
|
high intensity progressive resistance exercise training
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Change in Total Body Fat-free Mass
時間枠：16 weeks
|
change from baseline to 16 weeks in fat-free mass measured by DXA (Hologic Discovery W, version 12.6)
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16 weeks
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Change in Total Body Fat Mass
時間枠：16 weeks
|
Change from baseline to 16 weeks in total body fat mass.
|
16 weeks
|
|
Changes in Upper Body Strength.
時間枠：16 weeks
|
Strength was measured using the one-repetition maximum method.
Upper body strength was a composite of bench press, overhead press, seated row, and lateral pull-down strength.
|
16 weeks
|
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Change in Lower Body Strength
時間枠：16 weeks
|
Strength was measured using the one-repetition maximum method.
Lower body strength was a composite of knee flexion, knee extension, and leg press strength.
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16 weeks
|
協力者と研究者
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
Resistance trainingの臨床試験
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