Cerebrospinal Fluid (CSF) Raltegravir Substudy

Inclusion Criteria:

• Enrollment in a raltegravir parent protocol at UCSD.
• Willing to undergo lumbar puncture.
• Able to give informed consent. If cognitively impaired, a test will be administered to ensure adequate comprehension of the consent document and procedure.

Exclusion Criteria:

• Relative or absolute contraindication to lumbar puncture, such as current coagulopathy, thrombocytopenia (platelets<50,000/µL), hemophilia, or use of anticoagulant medication.
• Psychiatric disease that would interfere with study participation, in the opinion of the investigator.
• No major opportunistic infections within 30 days.
• Moderate or severe cognitive impairment. The proposed study does not have a neuropsychological objective.