Study of Split-course Chemoradiotherapy For Postoperative Locoregional Recurrence Of Non-small Cell Lung Cancer
15 januari 2021 bijgewerkt door: Hui Liu, Sun Yat-sen University
A Prospective, Randomized, Phase Ⅱ Study of Split-course Chemoradiotherapy For Locoregional Recurrence Of Non-small Cell Lung Cancer After Surgical Resection
This Phase II randomized study is to determine the efficacy of split-course irradiation with concurrent chemotherapy in locoregional recurrence of non-small cell lung cancer after surgical resection
Studie Overzicht
Toestand
Onbekend
Conditie
Interventie / Behandeling
Gedetailleerde beschrijving
This Phase II randomized study is to determine the efficacy of split-course irradiation with concurrent chemotherapy in locoregional recurrence of non-small cell lung cancer after surgical resection.
Patients received four cycles of weekly docetaxel(25mg/㎡) and nedaplatin(25mg/㎡), each of 1 day's duration, combined with split-course thoracic radiotherapy of 40-51 Gy/10-17 fractions and 15-24 Gy/5-8 fractions administered in the first and second courses, respectively, with one-month break. The primary end point is progression-free survival, which is the time that passes from the first day of radiotherapy to the date at which disease progresses. Progression-free survival will be calculated using the Kaplan-Meier method.Toxicities will be graded according to CTCAE v. 4.0.
Studietype
Ingrijpend
Inschrijving (Verwacht)
57
Fase
- Fase 2
Contacten en locaties
In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.
Studie Locaties
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Guangdong
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Guangzhou, Guangdong, China, 510000
- Werving
- Hui Liu
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Deelname Criteria
Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
18 jaar tot 75 jaar (Volwassen, Oudere volwassene)
Accepteert gezonde vrijwilligers
Nee
Geslachten die in aanmerking komen voor studie
Allemaal
Beschrijving
Inclusion Criteria:
- Pathologic confirmation of NSCLC.
- Patients have measurable or evaluable lesions based on the Response Evaluation Criteria in Solid Tumors (RECIST) criteria.
- Postoperative locoregional recurrence including ipsilateral hemithorax and the mediastinum.
- Eastern Cooperative Oncology Group (ECOG) performance status 0-1.
- Previously treated with chemotherapy or treatment-naive
- No previous chest radiotherapy, immunotherapy or biotherapy
- Hemoglobin≥10 mg/dL, platelet≥100000/μL,absolute neutrophil count ≥1500/μL
- Serum creatinine ≤1.25 times the upper normal limit(UNL), or creatinine clearance≥60 ml/min
- Bilirubin ≤1.5 times UNL, AST（SGOT）≤2.5 times UNL ,ALT（SGPT）≤2.5 times UNL,alkaline phosphatase ≤5 times UNL
- Forced expiratory volume at one second (FEV1) >0.8 L
- Coagulation tests within normal limits
- patients and their family signed the informed consents
Exclusion Criteria:
- Previous or recent another malignancy, except nonmelanoma skin cancer or cervical cancer in situ
- Second primary carcinoma of the lung
- Contraindication for chemotherapy
- Malignant pleural or pericardial effusion.
- Women in pregnancy, lactation period, or no pregnancy test 14 days before the first dos
- Women who has the probability of pregnancy without contraception
- Tendency of hemorrhage
- In other clinical trials within 30 days
- Addicted in drugs or alcohol, AIDS patients
- Uncontrollable seizure or psychotic patients without self-control ability
- Severe allergy or idiosyncrasy
- Not suitable for this study judged by researchers
Studie plan
Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Behandeling
- Toewijzing: NVT
- Interventioneel model: Opdracht voor een enkele groep
- Masker: Geen (open label)
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
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Experimenteel: split-course radiotherapy
The radiotherapy is delivered using simultaneous integrated boost (SIB)-IMRT.
Patients are irradiation at a palliative dose at the initial course: 40-51Gy/10-17f to PTV-GTV.
The disease is re-evaluated one month after the end of the initial course using CT.
The patient who achieved a partial remission according to the RECIST criteria and had a recovery of lung function should get the additional boost.
At the second course, the tumor is repositioned and scanned.
The residual tumor was then treated with the second course of radiotherapy.
A dose of 15-24 Gy/5-8f is delivered to the residue tumor.
Concurrent chemotherapy consists of weekly docetaxel(25mg/㎡) and nedaplatin(25mg/㎡), each of 1 day's duration.
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wekelijks docetaxel (25 mg/㎡) en nedaplatine (25 mg/㎡) gelijktijdig met bestraling van de borst
split-course chest radiation at 40-51 Gy/10-17f and 15-24 Gy/5-8f
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Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Tijdsspanne |
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progressievrije overleving
Tijdsspanne: 2 jaar
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2 jaar
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Secundaire uitkomstmaten
Uitkomstmaat |
Tijdsspanne |
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Algemeen overleven
Tijdsspanne: 2 jaar
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2 jaar
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Responspercentage
Tijdsspanne: 2 jaar
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2 jaar
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rate of patients who develop local recurrence or distant recurrence
Tijdsspanne: 2 year
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2 year
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rate of grade 3-4 radiation pneumonitis/esophagitis evaluated by Common Terminology Criteria for Adverse Events Version 4.0
Tijdsspanne: 1 year
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1 year
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Medewerkers en onderzoekers
Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.
Sponsor
Publicaties en nuttige links
De persoon die verantwoordelijk is voor het invoeren van informatie over het onderzoek stelt deze publicaties vrijwillig ter beschikking. Dit kan gaan over alles wat met het onderzoek te maken heeft.
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Studie record data
Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.
Bestudeer belangrijke data
Studie start (Werkelijk)
1 augustus 2015
Primaire voltooiing (Werkelijk)
1 juni 2020
Studie voltooiing (Verwacht)
1 juli 2021
Studieregistratiedata
Eerst ingediend
13 april 2016
Eerst ingediend dat voldeed aan de QC-criteria
28 december 2016
Eerst geplaatst (Schatting)
30 december 2016
Updates van studierecords
Laatste update geplaatst (Werkelijk)
20 januari 2021
Laatste update ingediend die voldeed aan QC-criteria
15 januari 2021
Laatst geverifieerd
1 januari 2021
Meer informatie
Termen gerelateerd aan deze studie
Trefwoorden
Aanvullende relevante MeSH-voorwaarden
Andere studie-ID-nummers
- GASTO-1017
Plan Individuele Deelnemersgegevens (IPD)
Bent u van plan om gegevens van individuele deelnemers (IPD) te delen?
ONBESLIST
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ExelixisNog niet aan het wervenKanker | Colorectale kanker | Hepatocellulair carcinoom (HCC) | Prostaatkanker | Niercelcarcinoom (RCC) | Gedifferentieerde schildklierkanker (DTC) | Pancreatische neuro-endocriene tumoren (pNET) | Non-Clear Cell Niercelcarcinoom (nccRCC) | Extra-Pancreatic NET (epNET)
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Masonic Cancer Center, University of MinnesotaWervingLymfoom | Folliculair lymfoom | Acute myeloïde leukemie | Multipel myeloom | Myelofibrose | Juveniele myelomonocytaire leukemie | Burkitt lymfoom | Acute lymfatische leukemie | Lymfoblastisch lymfoom | Chronische lymfatische leukemie | Lymfoplasmacytisch lymfoom | Acute leukemie | Mantelcellymfoom | Chronische myelogene... en andere voorwaardenVerenigde Staten
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ExelixisWervingHepatocellulair carcinoom (HCC) | Vaste tumor | Niet-kleincellige longkanker (NSCLC) | Niercelcarcinoom (RCC) | Hoofd-hals plaveiselcelcarcinoom (HNSCC) | Gemetastaseerde castratieresistente prostaatkanker (mCRPC) | Colorectale kanker (CRC) | Heldercellig niercelcarcinoom (ccRCC) | Urotheliaal carcinoom... en andere voorwaardenVerenigde Staten, Polen, Spanje, Australië, België, Nieuw-Zeeland, Zwitserland, Israël, Frankrijk, Oostenrijk, Duitsland, Italië, Verenigd Koninkrijk
Klinische onderzoeken op gelijktijdige chemotherapie
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Carl Zeiss Meditec AGVoltooid
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Glaukos CorporationActief, niet wervendGlaucoom | Glaucoom, open hoekCanada
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Sonova AGBeëindigdGehoorverliesVerenigde Staten
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Coloplast A/SVoltooidStoma Ileostoma | Stoma colostomaDenemarken
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Sonova AGVoltooidGehoorverliesZwitserland
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HutchmedWervingAcute myeloïde leukemieChina
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Seed HealthVoltooidVaginale persoonlijke verzorgingVerenigde Staten
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Johnson & Johnson Vision Care, Inc.Voltooid
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Fondazione del Piemonte per l'OncologiaVoltooid